Jeroen Declercq, J.W.M. Creemers Therapeutic Potential of Furin Inhibition: An Evaluation Using A Conditional Furin Knockout Mouse Model 9781615045259

Варианты приобретения

Цена: 6237.00р.
Кол-во:
Наличие: Поставка под заказ. Есть в наличии на складе поставщика.
Склад Америка: Есть
При оформлении заказа до:
Ориентировочная дата поставки:
При условии наличия книги у поставщика.

Добавить в корзину

в Мои желания

Автор: Jeroen Declercq, J.W.M. Creemers
Название: Therapeutic Potential of Furin Inhibition: An Evaluation Using A Conditional Furin Knockout Mouse Model
ISBN: 9781615045259
Издательство: Mare Nostrum (Eurospan)
Классификация:

Биохимия

Молекулярная биология

ISBN-10: 1615045252
Обложка/Формат: Paperback
Страницы: 30
Вес: 0.07 кг.
Дата издания: 01.10.2012
Серия: Colloquium series on protein activation and cancer
Язык: English
Иллюстрации: Colour illustrations
Размер: 235 x 191 x 2
Читательская аудитория: General (us: trade)
Ключевые слова: Biochemistry
Подзаголовок: An evaluation using a conditional furin knockout mouse model
Рейтинг:
Поставляется из: Англии
Описание: The proprotein convertase Furin is a serine endoprotease which cleaves protein precursors carboxyterminal of basic residues in motifs such as Arg–X–X–Arg and Lys/Arg–Arg. Cleavage usually results in activation of the proprotein but can also inactivate or modify the activity. Therefore, it is not surprising that it plays a major role in many physiological processes and pathologies, including cancer. The other proprotein convertases belonging to the same family, PC1/3, PC2, PACE4, PC4, PC5/6, and PC7, cleave at similar cleavage sites and provide partial redundancy. To unravel the specific role of Furin in vivo, knockout mouse models have been generated. Furin null mice die between e10.5 and e11.5 due to severe ventral closure defects and the failure of the heart tube to fuse and undergo looping morphogenesis. Therefore, a conditional Furin knockout mouse was generated to investigate the role of Furin in specific organs, such as pancreas, liver, T-cells, endothelial cells, and salivary glands, resulting in a severe or mild phenotype depending on the organ investigated. Partial or complete ablation of the Fur gene in salivary gland tumors significantly delayed tumorigenesis in mice. Therefore, Furin inhibition might be considered as a possible therapeutic strategy to treat certain pathologies, such as cancer.

Therapeutic Potential of Furin Inhibition: An Evaluation Using A Conditional Furin Knockout Mouse Model, Jeroen Declercq, J.W.M. Creemers