Ca2+-dependent Signal Transduction, James D. Johnson, Michael J. Bround, Tobias Albrecht
Автор: Ijsbrand M. Kramer Название: Signal Transduction ISBN: 0123948037 ISBN-13(EAN): 9780123948038 Издательство: Elsevier Science Рейтинг: Цена: 14483.00 р. Наличие на складе: Поставка под заказ.
Описание:
A reference on cellular signaling processes, the "third edition of Signal Transduction" continues in the tradition of previous editions, in providing a historical overview of how the concept of stimulus-response coupling arose in the early twentieth century and shaped our current understanding of the action of hormones, cytokines, neurotransmitters, growth factors and adhesion molecules. In a new chapter, an introduction to signal transduction, the book provides a concise overview of receptor mechanisms, from receptor ligand interactions to post-translational modifications operational in the process of bringing about cellular changes. The phosphorylation process, from bacteria to men, is discussed in detail.
"Signal transduction third edition" further elaborates on diverse signaling cascades within particular contexts such as muscle contraction, innate and adaptive immunity, glucose metabolism, regulation of appetite, oncogenic transformation and cell fate decision during development or in stem cell niches. The subjects have been enriched with descriptions of the relevant anatomical, histological, physiological or pathological condition. In-depth insight into a subject central to cell biology and fundamental to biomedicine, including the search for novel therapeutic interventionsEssential signaling events embedded in rich physiological and pathological contextsExtensive conceptual colour artwork to assist with comprehension of key topicsSpecial emphasis on how molecular structure determines protein function and subcellular localizationEmployment of unambiguous protein names (symbols) in agreement with leading protein- and gene databases, allowing the learner to extend his/her exploration on the web"
Cell Surface GRP78, a New Paradigm in Signal Transduction Biology presents a new paradigm that has emerged in the past decade with the discovery that various intracellular proteins may acquire new functions as cell surface receptors. Two very prominent examples are ATP synthase and GRP78. While the role of cell surface ATP synthase has been reviewed in various books, this book directs its attention to the story of cell surface GRP78.
Edited by the researcher who identified cell surface expression of the molecular chaperone GRP78 as a major factor in prostate cancer and other malignancies
Presents an in-depth treatment of the biological underpinnings of GRP78 and its connection to disease
Provides four-color illustrations that facilitate the narrative
Описание: Presents information on proteins dependent upon Vitamin B6, PQQ or other quinones for function. This work contains sections focusing on the mechanisms of folding and addressing the molecular physiology and pathology of these families of proteins, which are of biomedical interest.
Cellular Signal Processing offers a unifying view of cell signaling based on the concept that protein interactions act as sophisticated data processing networks that govern intracellular and extracellular communication. It is intended for use in signal transduction courses for undergraduate and graduate students working in biology, biochemistry, bioinformatics, and pharmacology, as well as medical students. The text is organized by three key topics central to signal transduction: the protein network, its energy supply, and its evolution. It covers all important aspects of cell signaling, ranging from prokaryotic signal transduction to neuronal signaling, and also highlights the clinical aspects of cell signaling in health and disease. This new edition includes expanded coverage of prokaryotes, as well as content on new developments in systems biology, epigenetics, redox signaling, and small, non-coding RNA signaling.
Автор: P. Aducci Название: Signal Transduction in Plants ISBN: 3034899386 ISBN-13(EAN): 9783034899383 Издательство: Springer Рейтинг: Цена: 14365.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Many systems involved in animal signaling are now shown to be present also in plants, and in view of the fast progress in this area, it will be possible in the near future to fully describe the content of the "black boxes" in the reaction chain specifically triggered by a signal.
Автор: Paul A. Hargrave; Klaus P. Hofmann; U. Benjamin Ka Название: Signal Transduction in Photoreceptor Cells ISBN: 3540537651 ISBN-13(EAN): 9783540537656 Издательство: Springer Рейтинг: Цена: 16769.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book deals with the mechanism of signal transduction in vertebrate and invertebrate photoreceptors. It contains contributions on the structure and function of rhodopsin or other G-coupled receptors, on the regulation of second messengers by enzyme cascade, the role of Ca2+ in light adaptation, control of ionic channels in photoreceptor cells.
Автор: Gerhard Gross Название: Stem Cell-dependent Therapies ISBN: 3110298260 ISBN-13(EAN): 9783110298260 Издательство: Walter de Gruyter Цена: 31603.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Multipotent mesenchymal stem cells (MSCs) are a heterogeneous population of cells which reside in a variety of tissues. They differentiate into several mesodermal lineages, secrete a multitude of trophic factors and contribute to tissue homeostasis. MSCs are able to exert immunosuppressive activities by interfering with inflammatory cytokine production and with T- and B-cell proliferation. These immunomodulating properties make MSCs promising candidates for the treatment of chronic inflammatory and autoimmune disorders. There are, however, certain caveats involved including inappropriate migration of cells in the body, immune rejection, tumor formation, or graft versus host disease (GvHD). This book investigates the current state of the MSC-dependent therapy of chronic inflammatory disorders and autoimmune diseases. Among the covered topics are GvHD, chronic kidney, liver and lung disease, ischemic heart and inflammatory bowel disease, diabetes, osteoarthritis, various rheumatic and neurological disorders and, lastly, tumors and solid organ transplantations. This book also questions the immunoprivileged status of MSCs, discusses the therapeutic role of MSCs in experimental animal disease models and their translation to the corresponding human disorders, envisions a role for MSCs in tumor interventions and, lastly, describes a systems biology approach for stem cells and inflammation.
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