Описание: 'As an innovative treatment of scientific topics with philosophical undertones, this is an impressive work, Some may not be convinced by the arguments, but for scientists and philosophers alike the author presents a thesis worth exploring.'CHOICEThe book describes a common ground between the biology of life and the humanity of life without compromising either discipline. It attempts to bridge the gap between our 'two cultures' -- the sciences and the humanities, as advocated by C P Snow fifty years ago. This book connects our meager existence to the entire living world and the universe, physically and spiritually, through the simple perspective of 'self, ' being defined as a system that seeks its own perpetuation.
Описание: 'As an innovative treatment of scientific topics with philosophical undertones, this is an impressive work, Some may not be convinced by the arguments, but for scientists and philosophers alike the author presents a thesis worth exploring.'CHOICEThe book describes a common ground between the biology of life and the humanity of life without compromising either discipline. It attempts to bridge the gap between our 'two cultures' -- the sciences and the humanities, as advocated by C P Snow fifty years ago. This book connects our meager existence to the entire living world and the universe, physically and spiritually, through the simple perspective of 'self, ' being defined as a system that seeks its own perpetuation.
Описание: This thesis describes the inception, design, and implementation of stereoselective desymmetrization reactions in the total synthesis of the natural products pactamycin and paspaline. In the case of pactamycin, the author develops a novel asymmetric Mannich reaction and symmetry-breaking reduction strategy to enable facile construction of the complex core architecture in fifteen steps using commercially available materials – the shortest synthesis to date. He subsequently demonstrates the flexibility of this approach in SAR investigations by highlighting the preparation of twenty-five unique pactamycin structural congeners. For paspaline, the author develops a biocatalytic desymmetrization strategy that allows the highly controlled synthesis of core stereochemistry and provides a platform for the development of new conceptual disconnections in the synthesis of 'steroid-like' natural products. This thesis offers a valuable resource for students embarking on a PhD in total synthesis.
Автор: Kenneth Maiese Название: Molecules to Medicine with mTOR ISBN: 0128027339 ISBN-13(EAN): 9780128027332 Издательство: Elsevier Science Рейтинг: Цена: 15999.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Molecules to Medicine with mTOR: Translating Critical Pathways into Novel Therapeutic Strategies is a one-stop reference that thoroughly covers the mechanistic target of rapamycin (mTOR). mTOR, also known as the mammalian target of rapamycin, is a 289-kDa serine/threonine protein kinase that is ubiquitous throughout the body and has a critical role in gene transcription and protein formation, stem cell development, cell survival and senescence, aging, immunity, tissue regeneration and repair, metabolism, tumorigenesis, oxidative stress, and pathways of programmed cell death that include apoptosis and autophagy. Incorporating a translational medicine approach, this important reference highlights the basic cellular biology of mTOR pathways, presents the role of mTOR during normal physiologic function and disease, and illustrates how the mechanisms of mTOR can be targeted for current and future therapeutic treatment strategies. Coverage of mTOR signaling includes the entire life cycle of cells that impacts multiple systems of the body including those of nervous, cardiovascular, immune, musculoskeletal, endocrine, reproductive, renal, and respiratory origin.
Covers the role of mTOR by internationally recognized expert contributors in the field.
Provides a clear picture of the complexity of mTOR signaling as well as of the different approaches that could target this pathway at various levels.
Includes analysis of the role of mTOR and in both health and disease.
Serves as an important resource for a broad audience of healthcare providers, scientists, drug developers, and students in both clinical and research settings.
Автор: Bochner Название: Adhesion Molecules in Allergic Disease ISBN: 0824798368 ISBN-13(EAN): 9780824798369 Издательство: Taylor&Francis Рейтинг: Цена: 41342.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This unique resource-the first book of its kind exclusively devoted to the subject-offers timely coverage of the cells, mechanisms, and proteins involved in allergic inflammation, emphasizing the latest advances in local cell recruitment.
Автор: Waluk Название: Conformational Analysis of Molecules ISBN: 0471297070 ISBN-13(EAN): 9780471297079 Издательство: Wiley Рейтинг: Цена: 44027.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In the last ten years, advances in laser spectroscopy have enabled researchers to selectively excite and follow a single molecule with ultrafast resolution.
Автор: Lin He Название: Mass Spectrometry Imaging of Small Molecules ISBN: 1493913565 ISBN-13(EAN): 9781493913565 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Mass Spectrometry Imaging of Small Molecules
Автор: Carlo Pellicciari; Marco Biggiogera Название: Histochemistry of Single Molecules ISBN: 1493967878 ISBN-13(EAN): 9781493967872 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: It begins with a section on vital histochemistry and continues with chapters on histochemistry as it relates to lectins, proteins, lipids, DNA and RNA, as well as plants.
Автор: Sarah A Woodson Название: Structures of large RNA molecules and their complexes,558 ISBN: 0128019344 ISBN-13(EAN): 9780128019344 Издательство: Elsevier Science Рейтинг: Цена: 23244.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in RNA folding and dynamics, RNA-protein interactions and large RNPs.
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