Alzheimer`s Disease and Infectious Causes: The Theory and Evidence, Moore Elaine A.
Автор: Rudolph Название: Alzheimer`s Disease ISBN: 1439827087 ISBN-13(EAN): 9781439827086 Издательство: Taylor&Francis Рейтинг: Цена: 17149.00 р. 24499.00-30% Наличие на складе: Есть (1 шт.) Описание:
In recent years, a tremendous amount of effort has been focused on better understanding the fundamentals of Alzheimer's disease (AD) to facilitate early and accurate diagnosis and appropriately targeted therapeutic treatments. Alzheimer's Disease: Targets for New Clinical, Diagnostic, and Therapeutic Strategies provides a detailed synopsis of the current state of the art of diagnostics and therapeutics and identifies emerging technologies and molecules that show promise in the management and treatment of AD.
With contributions from experts drawn from academia, clinical practice, and the biotechnology and pharmaceutical industries, the book explores:
The basis of AD and the role of Aβ oligomers in development of disease
Existing and emerging in vitro biomarker-based methodologies for the diagnosis of AD, focusing on genetic, biochemical, and conformational strategies
In vivo imaging diagnostic approaches
Evolving diagnostic criteria, health regulatory guidelines, biomarkers in clinical trials, and available and emerging therapies
Recent progress in small-molecule disease-modifier drug discovery efforts for AD, specifically in the areas of Aβ, tau, and emerging neuroprotective/neurorepair approaches
How a case study of AD raises issues regarding clinical and pathologic criteria, risk factors, and the amyloid hypothesis
The molecular conformational factors that govern the pathogenicity of aggregating proteins, and how these factors could represent new targets for disease-modifying therapies
The latest epidemiological, pathological, biochemical, and behavioral studies that may shed some light on the risk of developing AD and similar dementias after traumatic brain injury
Examining current hypotheses and suggesting possible new approaches to therapeutic clinical applications, this volume paves the way for a robust pipeline of therapeutics to combat not only AD, but a whole host of other neurodegenerative diseases.
Автор: Ryszard Pluta Название: Brain Ischemia: Alzheimers Disease Mechanisms ISBN: 1536151637 ISBN-13(EAN): 9781536151633 Издательство: Nova Science Рейтинг: Цена: 32312.00 р. Наличие на складе: Невозможна поставка.
Описание: This new book presents a summary of Alzheimers disease-related ischemic protein changes and gene expression as risk factors for the late-onset of sporadic Alzheimers disease, and their role in Alzheimers disease ischemic etiology. Ischemic brain changes were noted in the staining of different parts of an amyloid protein precursor, presenilin 1 and 2, tau protein, alfa-synuclein, and apolipoproteins A1, E and J. Current advances in understanding the ischemic etiology of Alzheimers disease has revealed dysregulation of Alzheimers disease-associated genes including presenilin 1 and 2, β-secretase, amyloid protein precursor, apoptosis, autophagy, mitophagy, and tau proteins. This book presents the relationship between these genes, dysregulated by cerebral ischemia, and the cellular and tissue neuropathology characteristic of Alzheimers disease. This book draws attention to the latest research confirming the theory that Alzheimers disease-related proteins and genes play an important role in ischemic brain damage, and ischemia is an essential and leading supplier for the onset and progression of sporadic Alzheimers disease. The above data comes from the latest research from leading and renowned scientists around the world, who present important information on the understanding of the ischemic etiology of Alzheimers disease. In the future, it is likely that the manipulation of ischemia and ischemia-activated Alzheimers disease-associated genes and their proteins will give new hope for the development of causal therapies urgently needed to prevent or treat neurodegenerative diseases such as Alzheimers disease. An innovative/modern approach to the etiology of Alzheimers disease in the chapter XII Ischemic etiology of Alzheimers disease will give the reader a glimpse of what is on the horizon.
Описание: "Winner of an "AJN" Book of the Year Award for 2010! "This book...provides important information on best practices and appropriate ways to care for a person with Alzheimer`s and advanced dementia. Drs. Martin and Sabbagh have assembled a team of experts to help craft recommendations that should ultimately become standards that all professional caregivers adopt."-Michael ReaganSon of former President Ronald ReaganPresident, Reagan Legacy Foundation This book testifies that caregivers can have a monumental impact on the lives of persons with advanced dementia. Through specialized programming and a renewed effort toward patient-centered care, caregivers can profoundly enrich the quality of life for these persons. Providing guidelines for health care professionals, caregivers, and family members, this book introduces palliative care programs and protocols for the treatment of people with advanced dementia. The book is designed to guide professional caregivers in meeting the needs of patients and their families, providing insight into the philosophy, assessment, planning, implementation, and evaluation measures involved in interdisciplinary palliative care. The chapter authors offer guidelines and standards of care based on contributions from nurses, physical therapists, social workers, dietitions, psychologists, family caregivers and pastors. An exhibit at the end of every chapter clearly articulates the standards of care appropriate for all advanced dementia facilities and health care staff. This book helps caregivers: Enhance the physiological, psychological, social, and spiritual well-being of the patient and the patient`s family Anticipate and meet the patient`s basic human needs: hunger, thirst, body positioning, hygiene, continence, and management of any pain Ensure that the patient`s surroundings are safe, comfortable, and homelike Address health care decisions that will support the patient`s right to self-determination until the end of life "
Автор: Fisher Название: Advances in Alzheimer`s and Parkinson`s Disease ISBN: 038772074X ISBN-13(EAN): 9780387720746 Издательство: Springer Рейтинг: Цена: 43184.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Contains the proceedings of the 2005 ADPD conference. This title deals not only with issues related individually to Alzheimer`s disease and Parkinson`s disease, but also with the integration of these and other related diseases. It covers topics ranging from immunology, neuroscience, and pharmacology to genetics and molecular biology.
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