Автор: Ramkumar Название: Inflammatory Mechanisms in Mediating Hearing Loss ISBN: 3319925067 ISBN-13(EAN): 9783319925066 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Common forms of preventable hearing loss are drug and noise-induced hearing loss which are believed to be produced by a similar mechanism. The generation of reactive oxygen species appears to be a common mechanism mediating hearing loss produced by these different sources. As such, a number of laboratories have focused their research towards identifying the sources of ROS production in the cochlea following administration of chemotherapeutic agents or noise exposure. This led to the identification of ROS generating enzymes, such as xanthine oxidases, nitric oxide synthase, and NADPH oxidases which are activated and/or induced during the development of hearing loss. A consequence of these findings was the implementation of antioxidants in preclinical studies for the treatment of hearing loss. These antioxidants have provided different levels of protection in animal and human studies, but none of these have been approved by the US Food and Drug Administration for the treatment of hearing loss. More recently, it was shown that noise-induced hearing loss was associated with recruitment of inflammatory cells and mediators in the cochlea. This finding would suggest that noise could produce injury to the cochlea which stimulates local and/or circulating inflammatory cells. A similar finding was observed in the cochlea following administration of the anticancer drug, cisplatin. In addition, our laboratory and others have provided a plausible mechanism by which noise or chemotherapeutic agents could stimulate the inflammatory response. Surprisingly, this mechanism involves ROS activation of transcription factors linked to inflammatory processes in the cochlea. These studies have led to the use of anti-inflammatory agents for the treatment of hearing loss. Preliminary studies targeting inflammatory cytokines appear especially promising in preclinical studies. A primary goal of this project is to describe our current understanding of the oxidant hypothesis of noise and drug-induced hearing loss and show how this relates to cochlear inflammation. Several different aspects of the cochlear inflammatory process will be discussed in detail, ranging from the sources of inflammatory cells, chemokines, inflammatory cytokines, and cochlea resident immune cells. Molecular pathways leading to activation of the local inflammatory process will be highlighted and treatment options will be discussed. The relevance of certain clinically used anti-inflammatory interventions, such as trans-typmanic steroids will also be discussed. Furthermore, we will examine recent patents focusing on the use of anti-inflammatory agents for the treatment of drug and noise-induced hearing loss.
Описание: In this book the best surgical solutions for conductive hearing loss due to ossicular fixations are thoroughly described and discussed. The first section covers thympanosclerosis, collating all knowledge on the pathogenesis and pathology of this obscure condition, as well as the surgical methods used in fixation of the ossicular chain, when caused by myringosclerosis and tympanosclerosis.The second section covers postinflammatory, posttraumatic, and postoperative bony fixations of the ossicular chain. In the third section, the voluminous topic of otosclerosis, in particular the evolution of stapes surgery, the various stapedectomy and stapedotomy methods, and the complications of surgery for otosclerosis, are covered in great detail. This section also includes the problems that are encountered in otosclerosis surgery when the ear has been affected with chronic otitis.In the fourth section, congenital ossicular fixations and defects are covered along with some new aspects on the classification and embryology of these problems.For all topics, there is in-depth discussion of the pathogenesis and pathology of the diseases in question. Excellent hand-drawn illustrations provide a level of detail and comprehension not attainable through photography.This book will cover tympanosclerotic, bony, and fibrous fixations, retractions, atelectasis, secretory and adhesive otitis, ventilation problems of the middle ear, cholesteatoma in the tympanic cavity and more!
Описание: Presenting an evidence-based approach to auditory (re)habilitation for adolescents with hearing loss, this book provides professionals with theoretical and practical strategies for intervention, targeting a historically overlooked population.
Описание: Since the first edition was published in 1998, considerable advances have been made in the fields of pitch perception and speech perception. In addition, there have been major changes in the way that hearing aids work, and the features they offer.
Название: Genetic Hearing Loss ISBN: 0367394928 ISBN-13(EAN): 9780367394929 Издательство: Taylor&Francis Рейтинг: Цена: 9492.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Genetic Hearing Loss branches into syndromic and nonsyndromic categorical directions in its coverage of the genetics behind hearing loss.
Описание: This book is a comprehensive and hands-on guide to working with deaf and hard-of-hearing children within and outside of the music classroom, balancing a technical overview of hearing loss with relevant music lessons, teaching practices, resources, and research promoting musical experiences for children who are deaf and hard-of-hearing.
Автор: Williams Diana Название: Early Listening Skills for Children with a Hearing Loss ISBN: 0367193469 ISBN-13(EAN): 9780367193461 Издательство: Taylor&Francis Рейтинг: Цена: 6889.00 р. Наличие на складе: Поставка под заказ.
Описание: Now in a revised second edition, Early Listening Skills is a practical manual for use with children and young people with underdeveloped listening skills related to hearing loss. The activities stimulate and develop auditory awareness and discrimination skills in children with a range of developmental levels and abilities.
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