Raul Delgado-Morales Neuroepigenomics in Aging and Disease 9783319852669

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Автор: Raul Delgado-Morales
Название: Neuroepigenomics in Aging and Disease
ISBN: 9783319852669
Издательство: Springer
Классификация:

Медицинская генетика

Генетика (немедицинская)

Белки

ISBN-10: 3319852663
Обложка/Формат: Soft cover
Страницы: 525
Вес: 8.07 кг.
Дата издания: 2018
Серия: Proteomics, Metabolomics, Interactomics and Systems Biology
Язык: English
Издание: Softcover reprint of
Иллюстрации: 39 illustrations, color; 2 illustrations, black and white; xiii, 525 p. 41 illus., 39 illus. in color.
Размер: 234 x 156 x 28
Читательская аудитория: Professional & vocational
Ключевые слова: Proteomics
Основная тема: Life Sciences
Ссылка на Издательство: Link
Рейтинг:
Поставляется из: Германии
Описание: Epigenetic mechanisms (DNA modifications, histone alterations and non-coding RNAs) are crucial for transcriptional regulation and alterations of the “physiological epigenome” are increasingly associated with human diseases. During the last decade the emerging field of neuroepigenomics have started to impact tremendously in areas such learning and memory, addiction or neurodegeneration. This expert volume covers the role of epigenetic molecular mechanism in regulation of central nervous system’s function, one of the most exciting areas of contemporary molecular neuroscience. The book describes the current knowledge on the epigenetic basis of human disease covering the complete lifespan: from neurodevelopment/childhood (Rett Syndrome, Rubinstein-Taybi, autism), adolescence (eating disorders, drug addiction, anxiety), adulthood (depression, schizophrenia, amyotrophic lateral sclerosis, Huntington’s disease) and elderly (Alzheimer’s disease, Parkinson’s disease). The book also covers the three major players on neuroepigenomic mechanisms: histones alterations, DNA modifications and non-coding RNAs, their roles at the molecular and cellular level and the impact of their alterations on neuronal function and behavior. Finally, a special chapter on state-of-the-art technologies helps the reader not only to understand epigenetic driven changes in human cognition and diseases but also the methodology that will help to generate paradigm shifts on our understanding of brain function and the role of the neuroepigenome in human diseases.
Дополнительное описание: Part I: Neurodevelopmental and Childhood Disorders.- MECP2, a modulator of Neuronal Chromatin Organization Involved in Rett Syndrome.- The Role of Noncoding RNAs in Neurodevelopmental Disorders: The Case of Rett Syndrome.- Rubinstein-Taybi Syndrome and Ep

Neuroepigenomics in Aging and Disease, Raul Delgado-Morales