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Synthesis of Therapeutic Oligonucleotides, Satoshi Obika; Mitsuo Sekine


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Автор: Satoshi Obika; Mitsuo Sekine
Название:  Synthesis of Therapeutic Oligonucleotides
ISBN: 9789811319112
Издательство: Springer
Классификация:



ISBN-10: 9811319111
Обложка/Формат: Hardcover
Страницы: 284
Вес: 0.72 кг.
Дата издания: 2018
Язык: English
Издание: 1st ed. 2018
Иллюстрации: 35 illustrations, color; 173 illustrations, black and white; viii, 284 p. 208 illus., 35 illus. in color.
Размер: 239 x 216 x 18
Читательская аудитория: Professional & vocational
Ключевые слова: Pharmaceutical Sciences/Technology
Основная тема: Biomedicine
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание:
This book presents the latest knowledge on a broad range of topics relating to the synthesis of natural and artificial oligonucleotides with therapeutic potential. Nucleic acid-based therapeutics are attracting much attention, and numerous therapeutic oligonucleotides, such as antisense oligonucleotides, siRNAs, splice-switching oligonucleotides, and nucleic acid aptamers, are being evaluated in clinical trials for the treatment of a variety of diseases. Synthesis of Therapeutic Oligonucleotides covers a broad range of topics in the field that are of high relevance to researchers, including the synthesis of natural and chemically modified oligonucleotides, the development of novel nucleic acid analogs, industrial scale synthesis and purification of oligonucleotides, and important aspects of chemistry, manufacturing, and controls (CMC). The aim is to provide new insights and inspire fresh ideas in nucleic acid chemistry that may ultimately lead to novel concepts and techniques and the discovery of more effective nucleic acid drugs. The book will be of high value for both established researchers in the field and students intending to specialize in nucleic acid chemistry research.

Дополнительное описание: Part 1. Synthesis of Natural Oligonucleotides.- Chapter 1. Non-protected Synthesis of Oligonucleotides.- Chapter 2. Various Coupling Agents in the Phosphoramidite Method for Efficient Oligonucleotide Synthesis.- Chapter 3. Recent Development of Chemical S



Triple Helix Forming Oligonucleotides

Автор: Claude Malvy; Annick Harel-Bellan; Linda L. Pritch
Название: Triple Helix Forming Oligonucleotides
ISBN: 1461373581 ISBN-13(EAN): 9781461373582
Издательство: Springer
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Цена: 20962.00 р.
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Описание: One of their most promising applications is as antiviral tools: they can specifically target a viral gene, even if it is integrated into the host genome, and be used to specifically inactivate the viral gene or even destroy the cells harboring this gene.

Revival: Delivery Strategies for Antisense Oligonucleotide Therapeutics (1995)

Название: Revival: Delivery Strategies for Antisense Oligonucleotide Therapeutics (1995)
ISBN: 1138558575 ISBN-13(EAN): 9781138558571
Издательство: Taylor&Francis
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Цена: 9033.00 р.
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Описание: With contributions from leading experts, this book is the first to focus solely on addressing the problems and reviewing the strategies currently being used to improve the delivery of antisense nucleic acids. Important delivery issues, such as improving biological stability, improving cell-specific targeting and cellular uptake.

Delivery Strategies for Antisense Oligonucleotide Therapeutics

Название: Delivery Strategies for Antisense Oligonucleotide Therapeutics
ISBN: 1138505897 ISBN-13(EAN): 9781138505896
Издательство: Taylor&Francis
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Цена: 33686.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: With contributions from leading experts, this book is the first to focus solely on addressing the problems and reviewing the strategies currently being used to improve the delivery of antisense nucleic acids. Important delivery issues, such as improving biological stability, improving cell-specific targeting and cellular uptake, manipulating subcellular distribution and producing liposomal delivery systems for antisense agents are comprehensively covered in this volume. This book links review-type articles with contributions that contain exciting never-before-published data on the cellular delivery of oligonucleotides. It stimulates reading for both established researchers and newcomers to the antisense field.

Modulating Gene Expression by Antisense Oligonucleotides to Understand Neural Functioning

Автор: Margaret M. McCarthy
Название: Modulating Gene Expression by Antisense Oligonucleotides to Understand Neural Functioning
ISBN: 1461372380 ISBN-13(EAN): 9781461372387
Издательство: Springer
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Цена: 26122.00 р.
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Описание: Aptly named `Television`s First Lady` by Walter Ames of the Los Angeles Times, actress Beverly Garland (1926-2008) is also regarded as a Western and science-fiction film icon. In addition to more than 700 TV appearances, she made more than 55 feature and made-for-television films. This comprehensive biography includes a foreword and afterword by her colleagues Joseph Campanella and Peggy Webber.


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