Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins, Raphael Enoque Ferraz de Paiva

Автор: Joel P. Mackay; David J. Segal
Название: Engineered Zinc Finger Proteins
ISBN: 1493957511 ISBN-13(EAN): 9781493957514
Издательство: Springer
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Цена: 23058.00 р.
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Описание: In this book, experts from some of the most active laboratories present detailed methods, guidance, and perspectives. It includes coverage of zinc finger nucleases, one of the most exciting tools for gene therapy and genome engineering in the past decade.

Автор: Raphael Enoque Ferraz de Paiva
Название: Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins
ISBN: 3030131505 ISBN-13(EAN): 9783030131500
Издательство: Springer
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Цена: 15372.00 р.
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Описание: This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C–S coupling.

Автор: Shiro Iuchi; Natalie Kuldell
Название: Zinc Finger Proteins
ISBN: 1441934340 ISBN-13(EAN): 9781441934345
Издательство: Springer
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Цена: 26120.00 р.
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