Cell-Based Therapy for Degenerative Retinal Disease, Marco A. Zarbin; Mandeep S. Singh; Ricardo P. Casa

Автор: Catherine Bowes Rickman; Matthew M. LaVail; Robert
Название: Retinal Degenerative Diseases
ISBN: 3319171208 ISBN-13(EAN): 9783319171203
Издательство: Springer
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Описание:

Part I Age-Related Macular Degeneration (AMD).- Apolipoprotein E Isoforms and AMD.- Role of Chemokines in Shaping Macrophage Activity in AMD.- Biology of p62/sequestosome-1 in Age-Related Macular Degeneration (AMD).- Gene Structure of the 10q26 locus: A Clue to Cracking the ARMS2/HTRA1 Riddle?.- Conditional Induction of Oxidative Stress in RPE: A Mouse Model of Progressive Retinal Degeneration.- Therapeutic Approaches to Histone Reprogramming in Retinal Degeneration.- A Brief Discussion on Lipid Activated Nuclear Receptors and Their Potential Role in Regulating Microglia in Age-Related Macular Degeneration (AMD).- Extracellular Matrix Alterations and Deposit Formation in AMD.- The NLRP3 Inflammasome and its Role in Age-related Macular Degeneration.- Oxidative Stress and the Nrf2 Anti-Oxidant Transcription Factor in Age-Related Macular Degeneration.- Aging Changes in Retinal Microglia and their Relevance to Age-related Retinal Disease.- VEGF-A and the NLRP3 Inflammasome in Age-Related Macular Degeneration.- Interrelation Between Oxidative Stress and Complement Activation in Models of Age-Related Macular Degeneration.- Gene-diet Interactions in Age-Related Macular Degeneration.- Challenges in the Development of Therapy for Dry Age-Related Macular Degeneration.- Nanoceria: A Potential Therapeutic for Dry AMD.- β-amyloidopathy in the Pathogenesis of Age-Related Macular Degeneration in Correlation with Neurodegenerative Diseases.- Part II Macular Dystrophies/Inherited Macular Degeneration.- Different Mutations in ELOVL4 Affect Very Long Chain Fatty Acid Biosynthesis to Cause Variable Neurological Disorders in Humans.- Mouse Models of Stargardt 3 Dominant Macular Degeneration.- Current Progress in Deciphering Importance of VLC-PUFA in the Retina.- Malattia Leventinese/Doyne Honeycomb Retinal Dystrophy: Similarities to Age-related Macular Degeneration and Potential Therapies.- Part III Inherited Retinal Degenerations.- Hsp90 as a Potential Therapeutic Target in Retinal Disease.- Leber Congenital Amaurosis: Genotypes and Retinal Structure Phenotypes.- A Chemical Mutagenesis Screen Identifies Mouse Models with ERG Defects.- Ablation of Chop Transiently Enhances Photoreceptor Survival But Does Not Prevent Retinal Degeneration in Transgenic Mice Expressing Human P23H Rhodopsin.- Identification of a Novel Gene on 10q22 Causing Autosomal Dominant Retinitis Pigmentosa (adRP).- FAM161A and TTC8 Are Differentially Expressed in Non-allelelic Early Onset Retinal Degeneration.- Mutations in the Dynein1 Complex are Permissible for Basal Body Migration in Photoreceptors but Alter Rab6 Localization.- RDS Functional Domains and Dysfunction in Disease.- TULP1 Missense Mutations Induces the Endoplasmic Reticulum Unfolded Protein Response Stress Complex (ER-UPR).- Understanding Cone Photoreceptor Cell Death in Achromatopsia.- Geranylgeranylacetone Suppresses N-methyl-N-nitrosourea-induced Photoreceptor Cell Loss in Mice.- My Retina Tracker(TM) An On-line International Registry for People Affected with Inherited Orphan Retinal Degenerative Diseases and their Genetic Relatives - A New Resource.- A Mini-Review: Animal Models of GUCY2D Leber Congenital Amaurosis (LCA1).- A Comprehensive Review of Mutations in the MERTK Proto-oncogene.- Part IV In Vivo Imaging and Other Diagnostic Advances.- New Developments in Murine Imaging for Assessing Photoreceptor Degeneration In Vivo.- Reliability and repeatability of Cone Density Measurements in Patients with Congenital Achromatopsia.- Quantitative Autofluorescence in Best Vitelliform Macular Dystrophy: RPE Lipofuscin is Not Increased in Non-Lesion Areas of Retina.- Interpretation of Flood-Illuminated Adaptive Optics Images in Subjects with Retinitis Pigmentosa.- Intra-familial Similarity of Wide-Field Fundus Autofluorescence in Inherited
Retinal Dystrophy.- Wide-Field Fundus Autofluorescence for Retinitis Pigmentosa

Автор: Catherine Bowes Rickman; Matthew M. LaVail; Robert
Название: Retinal Degenerative Diseases
ISBN: 3319371525 ISBN-13(EAN): 9783319371528
Издательство: Springer
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Цена: 25155.00 р.
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Описание:

Part I Age-Related Macular Degeneration (AMD).- Apolipoprotein E Isoforms and AMD.- Role of Chemokines in Shaping Macrophage Activity in AMD.- Biology of p62/sequestosome-1 in Age-Related Macular Degeneration (AMD).- Gene Structure of the 10q26 locus: A Clue to Cracking the ARMS2/HTRA1 Riddle?.- Conditional Induction of Oxidative Stress in RPE: A Mouse Model of Progressive Retinal Degeneration.- Therapeutic Approaches to Histone Reprogramming in Retinal Degeneration.- A Brief Discussion on Lipid Activated Nuclear Receptors and Their Potential Role in Regulating Microglia in Age-Related Macular Degeneration (AMD).- Extracellular Matrix Alterations and Deposit Formation in AMD.- The NLRP3 Inflammasome and its Role in Age-related Macular Degeneration.- Oxidative Stress and the Nrf2 Anti-Oxidant Transcription Factor in Age-Related Macular Degeneration.- Aging Changes in Retinal Microglia and their Relevance to Age-related Retinal Disease.- VEGF-A and the NLRP3 Inflammasome in Age-Related Macular Degeneration.- Interrelation Between Oxidative Stress and Complement Activation in Models of Age-Related Macular Degeneration.- Gene-diet Interactions in Age-Related Macular Degeneration.- Challenges in the Development of Therapy for Dry Age-Related Macular Degeneration.- Nanoceria: A Potential Therapeutic for Dry AMD.- β-amyloidopathy in the Pathogenesis of Age-Related Macular Degeneration in Correlation with Neurodegenerative Diseases.- Part II Macular Dystrophies/Inherited Macular Degeneration.- Different Mutations in ELOVL4 Affect Very Long Chain Fatty Acid Biosynthesis to Cause Variable Neurological Disorders in Humans.- Mouse Models of Stargardt 3 Dominant Macular Degeneration.- Current Progress in Deciphering Importance of VLC-PUFA in the Retina.- Malattia Leventinese/Doyne Honeycomb Retinal Dystrophy: Similarities to Age-related Macular Degeneration and Potential Therapies.- Part III Inherited Retinal Degenerations.- Hsp90 as a Potential Therapeutic Target in Retinal Disease.- Leber Congenital Amaurosis: Genotypes and Retinal Structure Phenotypes.- A Chemical Mutagenesis Screen Identifies Mouse Models with ERG Defects.- Ablation of Chop Transiently Enhances Photoreceptor Survival But Does Not Prevent Retinal Degeneration in Transgenic Mice Expressing Human P23H Rhodopsin.- Identification of a Novel Gene on 10q22 Causing Autosomal Dominant Retinitis Pigmentosa (adRP).- FAM161A and TTC8 Are Differentially Expressed in Non-allelelic Early Onset Retinal Degeneration.- Mutations in the Dynein1 Complex are Permissible for Basal Body Migration in Photoreceptors but Alter Rab6 Localization.- RDS Functional Domains and Dysfunction in Disease.- TULP1 Missense Mutations Induces the Endoplasmic Reticulum Unfolded Protein Response Stress Complex (ER-UPR).- Understanding Cone Photoreceptor Cell Death in Achromatopsia.- Geranylgeranylacetone Suppresses N-methyl-N-nitrosourea-induced Photoreceptor Cell Loss in Mice.- My Retina Tracker(TM) An On-line International Registry for People Affected with Inherited Orphan Retinal Degenerative Diseases and their Genetic Relatives - A New Resource.- A Mini-Review: Animal Models of GUCY2D Leber Congenital Amaurosis (LCA1).- A Comprehensive Review of Mutations in the MERTK Proto-oncogene.- Part IV In Vivo Imaging and Other Diagnostic Advances.- New Developments in Murine Imaging for Assessing Photoreceptor Degeneration In Vivo.- Reliability and repeatability of Cone Density Measurements in Patients with Congenital Achromatopsia.- Quantitative Autofluorescence in Best Vitelliform Macular Dystrophy: RPE Lipofuscin is Not Increased in Non-Lesion Areas of Retina.- Interpretation of Flood-Illuminated Adaptive Optics Images in Subjects with Retinitis Pigmentosa.- Intra-familial Similarity of Wide-Field Fundus Autofluorescence in Inherited
Retinal Dystrophy.- Wide-Field Fundus Autofluorescence for Retinitis Pigmentosa

Автор: Joe G. Hollyfield; Robert E. Anderson; Matthew M.
Название: Retinal Degenerative Diseases and Experimental Therapy
ISBN: 1475772246 ISBN-13(EAN): 9781475772241
Издательство: Springer
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Цена: 6986.00 р.
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Описание: To create a forum for scientists and clinicians interested in degenerative retinal diseases, we began in 1984 to organize a biennial symposium on Retinal Degeneration as a satellite meeting of the International Congress of Eye Research.

Автор: Joe G. Hollyfield; Robert E. Anderson; Matthew M L
Название: Retinal Degenerative Diseases
ISBN: 1489997725 ISBN-13(EAN): 9781489997722
Издательство: Springer
Рейтинг:
Цена: 34937.00 р.
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Описание: Retinal Degenerations is the result of the International Symposium on Retinal degeneration which has become perhaps the most important research meeting in the field. THe topics in this volume explore the etiology, cellular mechanisms, epidemiology, genetics, models and potential therapeutic measures for the blinding diseases of retinitis pigmentosa and age-related macular degeneration.

Автор: Robert E. Anderson; Joe G. Hollyfield; Matthew M.
Название: Retinal Degenerative Diseases
ISBN: 149395086X ISBN-13(EAN): 9781493950867
Издательство: Springer
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Цена: 46118.00 р.
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Описание: Basic Science Underlying Retinal Degeneration.- Analysis of Genes Differentially Expressed During Retinal Degeneration in Three Mouse Models.- Regulation of Angiogenesis by Macrophages.- Protein Kinase C Regulates Rod Photoreceptor Differentiation Through Modulation of STAT3 Signaling.- Pigment Epithelium-derived Factor Receptor (PEDF-R): A Plasma Membrane-linked Phospholipase with PEDF Binding Affinity.- The Function of Oligomerization-Incompetent RDS in Rods.- The Association Between Telomere Length and Sensitivity to Apoptosis of HUVEC.- Photoreceptor Guanylate Cyclases and cGMP Phosphodiesterases in Zebrafish.- RDS in Cones Does Not Interact with the Beta Subunit of the Cyclic Nucleotide Gated Channel.- Increased Expression of TGF-?1 and Smad 4 on Oxygen-Induced Retinopathy in Neonatal Mice.- ZBED4, A Novel Retinal Protein Expressed in Cones and Mьller Cells.- Tubby-Like Protein 1 (Tulp1) Is Required for Normal Photoreceptor Synaptic Development.- Growth-Associated Protein43 (GAP43) Is a Biochemical Marker for the Whole Period of Fish Optic Nerve Regeneration.- Multiprotein Complexes of Retinitis Pigmentosa GTPase Regulator (RPGR), a Ciliary Protein Mutated in X-Linked Retinitis Pigmentosa (XLRP).- Misfolded Proteins and Retinal Dystrophies.- Neural Retina and MerTK-Independent Apical Polarity of ?v?5 Integrin Receptors in the Retinal Pigment Epithelium.- Mertk in Daily Retinal Phagocytosis: A History in the Making.- The Interphotoreceptor Retinoid Binding (IRBP) Is Essential for Normal Retinoid Processing in Cone Photoreceptors.- Aseptic Injury to Epithelial Cells Alters Cell Surface Complement Regulation in a Tissue Specific Fashion.- Role of Metalloproteases in Retinal Degeneration Induced by Violet and Blue Light.- Mitochondrial Decay and Impairment of Antioxidant Defenses in Aging RPE Cells.- Ciliary Transport of Opsin.- Effect of Hesperidin on Expression of Inducible Nitric Oxide Synthase in Cultured Rabbit Retinal Pigment Epithelial Cells.- Profiling MicroRNAs Differentially Expressed in Rabbit Retina.- Unexpected Transcriptional Activity of the Human VMD2 Promoter in Retinal Development.- Microarray Analysis of Hyperoxia Stressed Mouse Retina: Differential Gene Expression in the Inferior and Superior Region.- Photoreceptor Sensory Cilia and Inherited Retinal Degeneration.- Role of Elovl4 Protein in the Biosynthesis of Docosahexaenoic Acid.- Molecular Genetics and Candidate Genes.- Molecular Pathogenesis of Achromatopsia Associated with Mutations in the Cone Cyclic Nucleotide-Gated Channel CNGA3 Subunit.- Mutation Spectra in Autosomal Dominant and Recessive Retinitis Pigmentosa in Northern Sweden.- 1 Rhodopsin Mutations in Congenital Night Blindness.- GCAP1 Mutations Associated with Autosomal Dominant Cone Dystrophy.- Genotypic Analysis of X-linked Retinoschisis in Western Australia.- Mutation Frequency of IMPDH1 Gene of Han Population in Ganzhou City.- Diagnostic, Clinical, Cytopathological and Physiologic Aspects of Retinal Degeneration.- Reversible and Size-Selective Opening of the Inner Blood-Retina Barrier: A Novel Therapeutic Strategy.- Spectral Domain Optical Coherence Tomography and Adaptive Optics: Imaging Photoreceptor Layer Morphology to Interpret Preclinical Phenotypes.- Pharmacological Manipulation of Rhodopsin Retinitis Pigmentosa.- Targeted High-Throughput DNA Sequencing for Gene Discovery in Retinitis Pigmentosa.- Advances in Imaging of Stargardt Disease.- Protamine Sulfate Downregulates Vascular Endothelial Growth Factor (VEGF) Expression and Inhibits VEGF and Its Receptor Binding in Vitro.- Computer-Assisted Semi-Quantitative Analysis of Mouse Choroidal Density.- Thioredoxins 1 and 2 Protect Retinal Ganglion Cells from Pharmacologically Induced Oxidative Stress, Optic Nerve Transection and Ocular Hypertension.- Near-Infrared Light Protect the Photoreceptor from Light-Induced Damage in Rats.- BDNF Improves the Efficacy ERG Amplitude Maintenance by Transplantation of Retinal Stem Ce

Автор: Bowes Rickman
Название: Retinal Degenerative Diseases
ISBN: 3030273776 ISBN-13(EAN): 9783030273774
Издательство: Springer
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Цена: 46118.00 р.
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Описание: This book contains the proceedings of the XVIII International Symposium on Retinal Degeneration (RD2018). A majority of those who spoke and presented posters at the meeting contributed to this volume. The blinding diseases of inherited retinal degenerations have no treatments, and age-related macular degeneration has no cures, despite the fact that it is an epidemic among the elderly, with 1 in 3-4 affected by the age of 70. The RD Symposium focused on the exciting new developments aimed at understanding these diseases and providing therapies for them. Since most major scientists in the field of retinal degenerations attend the biennial RD Symposia, they are known by most as the “best” and “most important” meetings in the field. The volume presents representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; candidate genes, cloning, mapping and other aspects of molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy. While advances in these areas of retinal degenerations were described, there will be many new topics that either are in their infancy or did not exist at the time of the last RD Symposium, RD2016. These include the role of inflammation and immunity, as well as other basic mechanisms, in age-related macular degeneration, several new aspects of gene therapy, and revolutionary new imaging and functional testing that will have a huge impact on the diagnosis and following the course of retinal degenerations, as well as to provide new quantitative endpoints for clinical trials. The retina is an approachable part of the central nervous system (CNS), and there is a major interest in neuroprotective and gene therapy for CNS diseases and neurodegenerations, in general. It should be noted that with successful and exciting initial clinical trials in neuroprotective and gene therapy, including the restoration of sight in blind children, the retinal degeneration therapies are leading the way towards new therapeutic measures for neurodegenerations of the CNS. Many of the successes recently reported in these areas of retinal degeneration sprang from collaborations established at previous RD Symposia, and many of those were reported at the RD2016 meeting and included in the current volume. We anticipate the excitement of those working in the field and those afflicted with retinal degenerations is reflected in the volume.

Автор: Robert E. Anderson; Matthew M. LaVail; Joe G. Holl
Название: New Insights Into Retinal Degenerative Diseases
ISBN: 1461355133 ISBN-13(EAN): 9781461355137
Издательство: Springer
Рейтинг:
Цена: 13974.00 р.
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Описание: Since 1984, we have organized satellite symposia on retinal degenerations that are held in conjunction with the biennial International Congress of Eye Research. The timing and location of our Retinal Degeneration Symposia have allowed scientists and clinicians from around the world to convene and present their exciting new findings.

Автор: John D. Ash; Christian Grimm; Joe G. Hollyfield; R
Название: Retinal Degenerative Diseases
ISBN: 1493952765 ISBN-13(EAN): 9781493952762
Издательство: Springer
Рейтинг:
Цена: 48774.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Автор: Ash
Название: Retinal Degenerative Diseases
ISBN: 3030092216 ISBN-13(EAN): 9783030092214
Издательство: Springer
Рейтинг:
Цена: 41925.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: The blinding diseases of inherited retinal degenerations have no treatments, and age-related macular degeneration has no cures, despite the fact that it is an epidemic among the elderly, with 1 in 3-4 affected by the age of 70. The RD Symposium will focus on the exciting new developments aimed at understanding these diseases and providing therapies for them. Since most major scientists in the field of retinal degenerations attend the biennial RD Symposia, they are known by most as the “best” and “most important” meetings in the field. The volume will present representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; candidate genes, cloning, mapping and other aspects of molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy.

While advances in these areas of retinal degenerations will be described, there will be many new topics that either were in their infancy or did not exist at the time of the last RD Symposium, RD2014. These include the role of inflammation and immunity, as well as other basic mechanisms, in age-related macular degeneration, several new aspects of gene therapy, and revolutionary new imaging and functional testing that will have a huge impact on the diagnosis and following the course of retinal degenerations, as well as to provide new quantitative endpoints for clinical trials. The retina is an approachable part of the central nervous system (CNS), and there is a major interest in neuroprotective and gene therapy for CNS diseases and neurodegenerations, in general. It should be noted that with successful and exciting initial clinical trials in neuroprotective and gene therapy, including the restoration of sight in blind children, the retinal degeneration therapies are leading the way towards new therapeutic measures for neurodegenerations of the CNS. Many of the successes recently reported in these areas of retinal degeneration sprang from collaborations established at previous RD Symposia, and many of those will be reported at the RD2018 meeting and included in the proposed volume. We anticipate the excitement of those working in the field and those afflicted with retinal degenerations will be reflected in the volume.

Автор: Ash
Название: Retinal Degenerative Diseases
ISBN: 3319754017 ISBN-13(EAN): 9783319754017
Издательство: Springer
Рейтинг:
Цена: 41925.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: The blinding diseases of inherited retinal degenerations have no treatments, and age-related macular degeneration has no cures, despite the fact that it is an epidemic among the elderly, with 1 in 3-4 affected by the age of 70. The RD Symposium will focus on the exciting new developments aimed at understanding these diseases and providing therapies for them. Since most major scientists in the field of retinal degenerations attend the biennial RD Symposia, they are known by most as the “best” and “most important” meetings in the field. The volume will present representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; candidate genes, cloning, mapping and other aspects of molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy.

While advances in these areas of retinal degenerations will be described, there will be many new topics that either were in their infancy or did not exist at the time of the last RD Symposium, RD2014. These include the role of inflammation and immunity, as well as other basic mechanisms, in age-related macular degeneration, several new aspects of gene therapy, and revolutionary new imaging and functional testing that will have a huge impact on the diagnosis and following the course of retinal degenerations, as well as to provide new quantitative endpoints for clinical trials. The retina is an approachable part of the central nervous system (CNS), and there is a major interest in neuroprotective and gene therapy for CNS diseases and neurodegenerations, in general. It should be noted that with successful and exciting initial clinical trials in neuroprotective and gene therapy, including the restoration of sight in blind children, the retinal degeneration therapies are leading the way towards new therapeutic measures for neurodegenerations of the CNS. Many of the successes recently reported in these areas of retinal degeneration sprang from collaborations established at previous RD Symposia, and many of those will be reported at the RD2018 meeting and included in the proposed volume. We anticipate the excitement of those working in the field and those afflicted with retinal degenerations will be reflected in the volume.

Автор: Joe G. Hollyfield; Robert E. Anderson; Matthew M L
Название: Retinal Degenerative Diseases
ISBN: 0387284648 ISBN-13(EAN): 9780387284644
Издательство: Springer
Рейтинг:
Цена: 38992.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Result of the International Symposium on Retinal degeneration. The topics in this volume explore the etiology, cellular mechanisms, epidemiology, genetics, models and potential therapeutic measures for the blinding diseases of retinitis pigmentosa and age-related macular degeneration.

Автор: Matthew M. LaVail; John Ash; Robert E. Anderson; J
Название: Retinal Degenerative Diseases
ISBN: 1493941739 ISBN-13(EAN): 9781493941735
Издательство: Springer
Рейтинг:
Цена: 36570.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: This book will contain the proceedings of the XIV International Symposium on Retinal Degeneration (RD2010), held July 13-17, 2010, in Mont-Tremblant, Quebec, Canada. and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy.