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Oligonucleotide-Based Therapies, Olof Gissberg; Rula Zain; Karin E. Lundin


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Автор: Olof Gissberg; Rula Zain; Karin E. Lundin
Название:  Oligonucleotide-Based Therapies
ISBN: 9781493996698
Издательство: Springer
Классификация:




ISBN-10: 149399669X
Обложка/Формат: Hardcover
Страницы: 344
Вес: 0.89 кг.
Дата издания: 2019
Серия: Methods in Molecular Biology
Язык: English
Издание: 1st ed. 2019
Иллюстрации: 46 illustrations, color; 23 illustrations, black and white; xiv, 353 p. 67 illus., 46 illus. in color.
Размер: 259 x 184 x 24
Читательская аудитория: Professional & vocational
Основная тема: Biomedicine
Подзаголовок: Methods and Protocols
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: This book provides a collection of comprehensive, up-to-date, and broadly applicable guides to the research and development fields of oligonucleotide (ON) therapeutics. Covering topics from the study of antisense and anti-gene effects to oligonucleotides in the context of drug discovery and development, the volume explores a wide-ranging and useful spectrum of methods and protocols needed to take full advantage of therapeutic applications involving ONs. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and practical, Oligonucleotide-Based Therapies: Methods and Protocols aims to be a great aid in the laboratory as well as an ideal reference guide when designing antisense and anti-gene oligonucleotides for therapeutic applications.

Дополнительное описание: Chemical Development of Therapeutic Oligonucleotides.- Tissue-Specific Delivery of Oligonucleotides.- Designing siRNA and Evaluating Its Effect on RNA Targets Using qPCR and Western Blot.- Antisense Oligonucleotides for Splice Modulation: Assessing Splice



Handbook of Analysis of Oligonucleotides and Related Products

Название: Handbook of Analysis of Oligonucleotides and Related Products
ISBN: 1138198455 ISBN-13(EAN): 9781138198456
Издательство: Taylor&Francis
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Цена: 12707.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Oligonucleotides represent one of the most significant pharmaceutical breakthroughs in recent years, showing great promise as diagnostic and therapeutic agents for malignant tumors, cardiovascular disease, diabetes, viral infections, and many other degenerative disorders. The Handbook of Analysis of Oligonucleotides and Related Products is an essential reference manual on the practical application of modern and emerging analytical techniques for the analysis of this unique class of compounds. A strong collaboration among thirty leading analytical scientists from around the world, the book provides readers with a comprehensive overview of the most commonly used analytical techniques and their advantages and limitations in assuring the identity, purity, quality, and strength of an oligonucleotide intended for therapeutic use. Topics discussed include: Strategies for enzymatic or chemical degradation of chemically modified oligonucleotides toward mass spectrometric sequencing Purity analysis by chromatographic or electrophoretic methods, including RP-HPLC, AX-HPLC, HILIC, SEC, and CGE Characterization of sequence-related impurities in oligonucleotides by mass spectrometry and chromatography Structure elucidation by spectroscopic methods (IR, NMR, MS) as well as base composition and thermal melt analysis (Tm) Approaches for the accurate determination of molar extinction coefficient of oligonucleotides Accurate determination of assay values Assessment of the overall quality of oligonucleotides, including microbial analysis and determination of residual solvents and heavy metals Strategies for determining the chemical stability of oligonucleotides The use of hybridization techniques for supporting pharmacokinetics and drug metabolism studies in preclinical and clinical development Guidance for the presentation of relevant analytical information towards meeting current regulatory expectations for oligonucleotide therapeutics This resource provides a practical guide for applying state-of-the-art analytical techniques in research, development, and manufacturing settings.

Triple Helix Forming Oligonucleotides

Автор: Claude Malvy; Annick Harel-Bellan; Linda L. Pritch
Название: Triple Helix Forming Oligonucleotides
ISBN: 1461373581 ISBN-13(EAN): 9781461373582
Издательство: Springer
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Цена: 20962.00 р.
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Описание: One of their most promising applications is as antiviral tools: they can specifically target a viral gene, even if it is integrated into the host genome, and be used to specifically inactivate the viral gene or even destroy the cells harboring this gene.

Revival: Delivery Strategies for Antisense Oligonucleotide Therapeutics (1995)

Название: Revival: Delivery Strategies for Antisense Oligonucleotide Therapeutics (1995)
ISBN: 1138558575 ISBN-13(EAN): 9781138558571
Издательство: Taylor&Francis
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Цена: 9033.00 р.
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Описание: With contributions from leading experts, this book is the first to focus solely on addressing the problems and reviewing the strategies currently being used to improve the delivery of antisense nucleic acids. Important delivery issues, such as improving biological stability, improving cell-specific targeting and cellular uptake.

Delivery Strategies for Antisense Oligonucleotide Therapeutics

Название: Delivery Strategies for Antisense Oligonucleotide Therapeutics
ISBN: 1138505897 ISBN-13(EAN): 9781138505896
Издательство: Taylor&Francis
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Цена: 33686.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: With contributions from leading experts, this book is the first to focus solely on addressing the problems and reviewing the strategies currently being used to improve the delivery of antisense nucleic acids. Important delivery issues, such as improving biological stability, improving cell-specific targeting and cellular uptake, manipulating subcellular distribution and producing liposomal delivery systems for antisense agents are comprehensively covered in this volume. This book links review-type articles with contributions that contain exciting never-before-published data on the cellular delivery of oligonucleotides. It stimulates reading for both established researchers and newcomers to the antisense field.


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