Therapeutic Enzymes: Function and Clinical Implications, Nikolaos Labrou
Автор: Matsumoto Rae R., Bowen Wayne D., Su Tsung-Ping Название: Sigma Receptors / Chemistry, Cell Biology and Clinical Implications ISBN: 0387365125 ISBN-13(EAN): 9780387365121 Издательство: Springer Рейтинг: Цена: 33401.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book provides an update on sigma receptors, and summarizes recent advances in the medicinal chemistry, molecular biology, and cell biology of sigma receptors. It describes the functional effects mediated by these receptors and the potential clinical implications of these actions. This information is put in a historical perspective to help newcomers to the field successfully navigate the confusing early history surrounding these proteins, and provides a launching point from which future studies and research directions can easily be developed. Major advances in our understanding of sigma receptors have been made during the past few years. This book will facilitate exciting new research that could lead to significant advances in the treatment of neurologic, psychiatric, cardiovascular, immunologic, and gastrointestinal disorders through a better understanding of sigma receptors.
Автор: Cordero Название: Inflammasomes: Clinical and Therapeutic Implications ISBN: 3319893890 ISBN-13(EAN): 9783319893891 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The inflammasome is a protein complex composed of an intracellular sensor—typically a Nod-like receptor (NLR), the precursor procaspase-1, and the adaptor ASC. Inflammasome activation leads to the maturation of caspase-1 and the processing of its substrates, IL-1? and IL-18. The inflammasome has been implicated numerous diseases, and blockade of inflammasome-derived IL-1? has beneficial effects on several of these diseases. Different books have been edited about the biology of inflammasomes and about methods to study, however, the implication of this complex in the different diseases and pathological conditions show the need of a book about the clinical implications and therapeutic options. This project will show the context where inflammasomes are being studied and the molecular implications in the medical and clinical contexts. Other important topic of the inflammasomes will be the development of pharmacological inhibitors in order to improve new clinical applications. In this sense, we can find new drugs with inhibitory effects or old drugs with an inhibitory potential effect. There is a need for re-establishing the real benefits of the inflammasome inhibitions in pathological situations and the management of the differents diseases where inflammasomes are implicated.
Автор: Mario D. Cordero; El?sabet Alcocer-G?mez Название: Inflammasomes: Clinical and Therapeutic Implications ISBN: 3030077586 ISBN-13(EAN): 9783030077587 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The inflammasome is a protein complex composed of an intracellular sensor—typically a Nod-like receptor (NLR), the precursor procaspase-1, and the adaptor ASC. Inflammasome activation leads to the maturation of caspase-1 and the processing of its substrates, IL-1? and IL-18. The inflammasome has been implicated numerous diseases, and blockade of inflammasome-derived IL-1? has beneficial effects on several of these diseases. Different books have been edited about the biology of inflammasomes and about methods to study, however, the implication of this complex in the different diseases and pathological conditions show the need of a book about the clinical implications and therapeutic options. This project will show the context where inflammasomes are being studied and the molecular implications in the medical and clinical contexts. Other important topic of the inflammasomes will be the development of pharmacological inhibitors in order to improve new clinical applications. In this sense, we can find new drugs with inhibitory effects or old drugs with an inhibitory potential effect. There is a need for re-establishing the real benefits of the inflammasome inhibitions in pathological situations and the management of the differents diseases where inflammasomes are implicated.
Автор: William Clarke Название: Clinical Challenges in Therapeutic Drug Monitoring ISBN: 0128020253 ISBN-13(EAN): 9780128020258 Издательство: Elsevier Science Рейтинг: Цена: 6230.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: "
Clinical Challenges in Therapeutic Drug Monitoring: Special Populations, Physiological Conditions and Pharmacogenomic"s focuses on critical issues in therapeutic drug monitoring including special requirements of therapeutic drug monitoring important to special populations (infants and children, pregnant women, elderly patients, and obese patients). The book also covers issues of free drug monitoring and common interferences in using immunoassays for therapeutic drug monitoring.
This book is essential reading for any clinician, fellow, or trainee who wants to gain greater insight into the process of therapeutic drug monitoring for individual dosage adjustment and avoiding drug toxicity for certain drugs within a narrow therapeutic window. The book is written specifically for busy clinicians, fellows, and trainees who order therapeutic drug monitoring and need to get more familiar with testing methodologies, issues of interferences, and interpretation of results in certain patient populations. Offers busy clinicians, pathologists, and trainees a concise resource on the key aspects and critical issues in therapeutic drug monitoringFocuses on patient populations such as infants and children, pregnant women, elderly patients, and obese patients, who have special requirements in therapeutic drug monitoringExplores special topics in therapeutic drug monitoring including free drug monitoring and common immunoassay interferenceExplains how individual dosage adjustments can prevent drug toxicity for certain drugs within a narrow therapeutic window
Описание: Volume 19, entitled Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic of the series Metal Ions in Life Sciences centers on the role of metal ions in clinical medicine. Metal ions are tightly regulated in human health: while essential to life, they can be toxic as well. Following an introductory chapter briefly discussing several important metal-related drugs and diseases and a chapter about drug development, the focus is fi rst on iron: its essentiality for pathogens and humans as well as its toxicity. Chelation therapy is addressed in the context of thalassemia, its relationship to neurodegenerative diseases and also the risks connected with iron administration are pointed out. A subject of intense debate is the essentiality of chromium and vanadium. For example, chromium(III) compounds are taken as a nutritional supplement by athletes and bodybuilders; in contrast, chromate, Cr(VI), is toxic and a carcinogen for humans. The benefi cial and toxic effects of manganese, cobalt, and copper on humans are discussed. The need for antiparasitic agents is emphasized as well as the clinical aspects of metal-containing antidotes for cyanide poisoning. In addition to the essential and possibly essential ones, also other metal ions play important roles in human health, causing harm (like the metalloid arsenic, lead or cadmium) or being used in diagnosis or treatment of human diseases, like gadolinium, gallium, lithium, gold, silver or platinum. The impact of this vibrant research area on metals in the clinic is provided in 14 stimulating chapters, written by internationally recognized experts from the Americas, Europe and China, and is manifested by approximately 2000 references, and about 90 illustrations and tables. Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic is an essential resource for scientists working in the wide range from pharmacology, enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine ... not forgetting that it also provides excellent information for teaching.
Автор: Jawahar L. Mehta; Pankaj Mathur; Naranjan S. Dhall Название: Biochemical Basis and Therapeutic Implications of Angiogenesis ISBN: 3319611143 ISBN-13(EAN): 9783319611143 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Leading authorities on the biochemistry of this complex physiological process explain its critical role in human growth and development as well as the pathogenesis of cancer, heart disease, and other morbidities. The book fully updates the current literature.
Автор: Martin Morad; Winifred G. Nayler; Stanislav Kazda; Название: The Calcium Channel: Structure, Function and Implications ISBN: 3540500618 ISBN-13(EAN): 9783540500612 Издательство: Springer Рейтинг: Цена: 12157.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This is the first book to summarize experimental results from the new, rapidly expanding field of research into the calcium channel in cell membrane. In the last decade it has been established that calcium ions reach their target intracellular system by passing through specialized calcium channels in the membrane.
Описание: This book discusses organoselenium chemistry and biology in the context of its therapeutic potential, taking the reader through synthetic techniques, bioactivity and therapeutic applications
Автор: Peplow Philip V., Martinez Bridget, Calin George A. Название: Micrornas in Diseases and Disorders: Emerging Therapeutic Targets ISBN: 1788013948 ISBN-13(EAN): 9781788013949 Издательство: Royal Society of Chemistry Рейтинг: Цена: 48854.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: MicroRNAs in Diseases and Disorders highlights the role of miRNAs in the development and progression of a variety of diseases and the utilization of miRNA targets in treatment. This book also includes the use of miRNAs as diagnostic and prognostic biomarkers for disease.
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