Collagen, Irit Sagi; Nikolaos A. Afratis

Автор: Peter Fratzl
Название: Collagen
ISBN: 1441944818 ISBN-13(EAN): 9781441944818
Издательство: Springer
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Описание: Not only does this book provide a comprehensive review of current research advances in collagen structure and mechanics, it also explores this biological macromolecule`s many applications in biomaterials and tissue engineering.

Автор: Eugene J. Kucharz
Название: The Collagens: Biochemistry and Pathophysiology
ISBN: 3642761992 ISBN-13(EAN): 9783642761997
Издательство: Springer
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Описание: Quam magnijicata sunt opera tua, Domine Omnia in sapientia feciti, plena est terra creaturis tuis. Psalm us CIV: XXIV. The days when the answer to the questions "What is collagen and what is it for?" was simple and short are gone. Nowadays, collagen cannot be considered as a single and metabolic inert fibrous protein responsible only for some mechanical proper- ties of tissues. The family of collagen proteins increases rapidly, and new collagens are still being discovered. They differ each from the other, and only the basic amino acid sequence con- taining proline and hydroxyproline is the one constant and unique feature of proteins which are very different in all other aspects. This heterogeneity is related to the variety of their bio- logical functions. The list of physiological aspects involving collagens as well as the number of disorders associated with collagen abnormalities are expanding rapidly. The structure and function of almost every organ are in some way related to connective tissue and to collagens in particular. Our knowledge in this field is significantly growing but is still far from com- plete. The efforts to modify collagen gene expression, structure, and metabolism in order to manage some disorders are a new goal of pharmacology and are a natural sequel of the progress- ing understanding of the pathophysiological role of collagens. This book provides a comprehensive overview of the patho- physiological aspects of collagens with special emphasis on medical problems, i. e.

Автор: Karsdal, Morten
Название: Biochemistry of Collagens, Laminins and Elastin
ISBN: 0128098473 ISBN-13(EAN): 9780128098479
Издательство: Elsevier Science
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Описание: Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers provides a comprehensive introduction to collagen and structural proteins. Type I collagen is one of the most abundant molecules in the body, playing essential roles in different tissues, particularly bone and skin. A key aspect of type I collagen is its post-translational modifications which are essential for correct synthesis and structural integrity of collagens, for tissue-specific functionality, as well as for application as biomarkers of different pathologies. . This volume summarizes current data on key structural proteins (collagens, laminins and elastin), reviews how these molecules affect pathologies, and describes selected modifications of proteins that result in altered signaling properties of the original extracellular matrix component. Further, it discusses the novel concept that an increasing number of components of the ECM harbor cryptic signaling functions that may be viewed as endocrine functions. Additionally, it highlights how this knowledge can be exploited to modulate fibrotic disease.

Автор: Gopalasamudram Ramachandran
Название: Biochemistry of Collagen
ISBN: 1475746040 ISBN-13(EAN): 9781475746044
Издательство: Springer
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Описание: Collagen is a fascinating protein not only because of its ubiquitous occurrence in multicellular animals, but also because of its unique chemi- cal structure. Follow- ing the consideration of primary and secondary structure of collagen, the three-dimensional arrangement of collagen molecules in the fibrils is covered by Miller in Chapter 3.