Progranulin and Central Nervous System Disorders, Hideaki Hara; Masato Hosokawa; Shinsuke Nakamura;
Автор: Bateman Название: Progranulin ISBN: 1493985574 ISBN-13(EAN): 9781493985579 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Preface...Table of Contents...Contributing Authors... Part I Introduction 1. A Brief Overview of Progranulin in Health and DiseaseAndrew Bateman, Siu Tim Cheung, and Hugh P.J. Bennett Part II Analytical and In Vitro Methods for the Study of Progranulin Biology 2. Chromatographic Methods for the Purification of Granulin PeptidesAndrew Bateman, Babykumari Chitramuthu, and Hugh P.J. Bennett 3. Methods for Expression and Purification of Biologically Active Recombinant ProgranulinChun Yu Zhao and Andrew Bateman 4. Large-Scale Generation of Recombinant Granulin Peptides in E. coliDmitri Tolkachev 5. Nuclear Magnetic Resonance Spectroscopy in Analysis of Granulin Three-Dimensional Structure and Cysteine BridgingDmitri Tolkatchev 6. Data Mining: Applying the AD&FTD Mutation Database to ProgranulinMarc Cruts and Christine Van Broeckhoven Part III Methods to Investigate the Role of Prgranulin in Cancer 7. Measurement of Circulating Progranulin (PGRN/GP88/GEP) by Enzyme-Linked Immunosorbent Assay and Application in Human DiseasesGinette Serrero and David Hicks 8. Immunohistochemical Detection of Progranulin (PGRN/GP88/GEP) in Tumor Tissues as a Cancer Prognostic BiomarkerGinette Serrero and David Hicks 9. Analysis of Progranulin-Mediated Akt and MAPK ActivationShi-Qiong Xu, Simone Buraschi, Ryuta Tanimoto, Manuela Stefanello, Antonio Belfiore, Renato V. Iozzo, and Andrea Morrione 10. Mouse Monoclonal Antibodies Against Progranulin (PGRN/GEP) as Therapeutics in Preclinical Cancer ModelsChi Wai Yip, Phyllis F.Y. Cheung, Nicholas C.L. Wong, Sze Wai Fung, and Siu Tim Cheung 11. Methods to Analyze the Role of Progranulin (PGRN/GEP) on Cancer Stem Cell FeaturesPhyllis F.Y. Cheung and Siu Tim Cheung 12. Methods to Study the Role of Progranulin in the Tumor MicroenvironmentMoshe Elkabets and Samuel Brook Part IV Animal Models to Study the Role of Progragulin in Health and Disease 13. Methods to Investigate the Molecular Basis of Progranulin Action on Neurons In Vivo using Caenorhabditis elegansJames Julian Doyle and J. Alex Parker 14. The Use of Caenorhabditis elegans to Study Progranulin in the Regulation of Programmed Cell Death and Stress ResponseTsung-Yuan Hsu, Victoria J. Butler, and Aimee W. Kao 15. Application of Zebrafish and Knockdown Technology to Define Progranulin Neuronal FunctionBabykumari P. Chitramuthu and Hugh P.J. Bennett 16. Methods to Investigate the Molecular Basis of Progranulin Actions on Brain and Behavior In Vivo Using Knockout MiceJan Boddaert, Hans Wils, and Samir Kumar-Singh 17. Methods to Investigate the Protection Againts Neurodegenerative Disorders Provided by Progranulin Gene Transfer in the BrainJackalina M. Van Kampen 18. The Interaction between Progranulin with Sortilin and the LysosomeXiaolai Zhou, Peter M. Sullivan, Daniel H. Paushter, and Fenghua Hu 19. Methods to Study the Role of Progranulin in Preimplanatation Mouse Embryo DevelopmentLaura Diaz-Cueto, Fabian Arechavaleta-Velasco, and George L. Gerton 20. Establishment of a Modified Collagen-Induced Arthritis Mouse Model to Investigate the Anti-Inflammatory Activity of Progranulin in Inflammatory ArthritisJian-Iu Wei and Chuan-ju Liu
Автор: Andrew Bateman; Hugh P.J. Bennett; Siu Tim Cheung Название: Progranulin ISBN: 1493993259 ISBN-13(EAN): 9781493993253 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Поставка под заказ.
Описание:
This volume explores experimental strategies to study progranulin as a regulatory protein in biological and disease processes. The chapters in this book are divided into four parts: Part One is an introduction to the topic; Part Two looks at analytical and in vitro methods to study progranulin biology; Part Three discusses the role of progranulin in cancer; and Part Four describes the process of using animal models to study progranulin in health and disease. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Cutting-edge and thorough, Progranulin: Methods and Protocols is a valuable resource for experienced researchers who want to expand their studies of this field, and newcomers who want to begin including progranulin into their work.
Автор: Peter Riederer; M.B.H. Youdim Название: Iron in Central Nervous System Disorders ISBN: 3211825207 ISBN-13(EAN): 9783211825204 Издательство: Springer Рейтинг: Цена: 12157.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Thus nutritional iron defi- ciency and iron overload afflict some 500-600 million people. It is also well recognized that too little or too much iron can produce profound effects on the metabolic state of the cell, and therefore the regulation of iron uptake and disposition is tightly relegated by the cell.
Автор: Firas H. Kobeissy et al Название: Injury Models of the Central Nervous System ISBN: 1493938142 ISBN-13(EAN): 9781493938148 Издательство: Springer Рейтинг: Цена: 25155.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume discusses experimental brain injury models thatcontain valuable information carefully chosen to widen the researchers’ horizonabout neurotrauma. Injury Models of Central Nervous System: Methods and Protocols contains relevant experimental design approaches that have beenadapted and made ready for application in laboratory settings. For easiernavigation, the chapters are categorized into 6 parts: Introduction, GeneralConsideration in Using Animal Laboratory in CNS Injury Research, Classical TBIModels and Their Link with Pathophysiological Features of CBS Injury – Models,Special Topics in CNS Trauma: Comorbid Conditions in CNS Injury, OutcomeMeasures in Brain Injury Models, and Future Directions. Written in the highly successful Methods inMolecular Biology series format, chapters include introductions to theirrespective topics, lists of the necessary materials and reagents, step-by-step,readily reproducible laboratory protocols, and tips on troubleshooting andavoiding known pitfalls.Practical and thorough, Injury Models of Central Nervous Systems: Methods and Protocols, is a very useful reference towards theprogress of this discipline.
Nanomedicine in Central Nervous System Injury and Repair (IRN), Volume 137, the latest release in the International Review of Neurobiology series presents comprehensive chapters that cover a broad range of topics, including, but not limited to, how Diabetes exacerbates methamphetamine induced blood-brain barrier breakdown, edema formation, oxidative stress and myelin damage, and how Focal blast brain injury induces rapid edema formation, blood-brain barrier breakdown and intensive cellular damage. In addition, the Neuroprotective effects of a multimodal drug cerebrolysin are explored, as is how Nanowired cerebrolysin potentiates neuroprotective effects of histamine H3 receptor inverse agonist and antagonist with partial H4 agonist in Alzheimer's Disease.
This series reviews current knowledge and understanding on how to repair the damaged spinal cord and brain with nanomedicine, detailing new therapeutic advances and providing a starting point for researchers and practitioners entering the field.
Provides cutting-edge research on the damaged spinal cord and brain
Presents new therapeutic advances
Reviews current knowledge and understanding
Автор: Bruno P. Guiard; Giuseppe Di Giovanni Название: 5-HT2A Receptors in the Central Nervous System ISBN: 3319704729 ISBN-13(EAN): 9783319704722 Издательство: Springer Рейтинг: Цена: 30745.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: 5-HT2A receptors are G-protein coupled receptors that are widely distributed throughout the brain, most notably on neuronal and glial cells. 5-HT2A receptors have been implicated in various central physiological functions including mood regulation, memory, sleep, nociception, eating, and reward behaviors, and they are also believed to control the cardiovascular system. This book provides a comprehensive overview of these receptors including sections on their properties and distribution, approaches for their study, their role in a number of brain functions and diseases, and their role as therapeutic targets. ?
Автор: Keiji Sano; Shozo Ishii Название: Plasticity of the Central Nervous System ISBN: 3709189470 ISBN-13(EAN): 9783709189474 Издательство: Springer Рейтинг: Цена: 12157.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Distinguished experts from the fields of neurosurgery, neurology, neurophysiology, anatomy, pathology, oncology, and pharmacology discussed the following topics: - Molecular and cellular basis of plasticity - Regeneration and growth in the CNS - Self-organization of neuronal network - Brain oedema - a reparatory process?
Автор: Klaus Ballanyi Название: Isolated Central Nervous System Circuits ISBN: 1493961837 ISBN-13(EAN): 9781493961832 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This Neuromethods series volume offers protocols and examples for exciting results from the labs of renowned experts. Covers patch-clamp, multiphoton imaging, live fluorescent protein expression, immunohistochemistry techniques, `organotypic` slices and more.
Автор: Brodal Название: The Central Nervous System.2003 ISBN: 0195165608 ISBN-13(EAN): 9780195165609 Издательство: Oxford Academ Цена: 8712.00 р. Наличие на складе: Поставка под заказ.
Описание: A major goal of this well-established textbook is to provide knowledge and understanding of neuroscience as a basis for clinical thinking. The strong emphasis on linking basic sciences with their clinical application has implications for the choices of which topics to treat in depth and which to treat more summarily - making this different from most other neuroscience textbooks. For example, topics of great practical importance like the cranial nerves, the autonomic nervous system, and pain are treated in depth.
Автор: S.C. Sharma; A.M. Goffinet Название: Development of the Central Nervous System in Vertebrates ISBN: 1461363152 ISBN-13(EAN): 9781461363156 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of a NATO ASI held in Maratea, Italy, June 23-July 6, 1991.
Автор: Bruno P. Guiard; Giuseppe Di Giovanni Название: 5-HT2A Receptors in the Central Nervous System ISBN: 3319889451 ISBN-13(EAN): 9783319889450 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Поставка под заказ.
Описание: 5-HT2A receptors are G-protein coupled receptors that are widely distributed throughout the brain, most notably on neuronal and glial cells. 5-HT2A receptors have been implicated in various central physiological functions including mood regulation, memory, sleep, nociception, eating, and reward behaviors, and they are also believed to control the cardiovascular system. This book provides a comprehensive overview of these receptors including sections on their properties and distribution, approaches for their study, their role in a number of brain functions and diseases, and their role as therapeutic targets. ?
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