Описание: This thesis addresses the development of a new force spectroscopy tool, correlation force spectroscopy (CFS) for the measurement of the properties of very small volumes of material (molecular to m3) at kHz-MHz frequency range.
Автор: Decker, Michael Название: Design of Hybrid Molecules for Drug Development ISBN: 0081010117 ISBN-13(EAN): 9780081010112 Издательство: Elsevier Science Рейтинг: Цена: 24423.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Design of Hybrid Molecules for Drug Development reviews the principles, advantages, and limitations involved with designing these groundbreaking compounds. Beginning with an introduction to hybrid molecule design and background as to their need, the book goes on to explore a range of important hybrids, with hybrids containing natural products, molecules containing NO- and H2S-donors, dual-acting compounds acting as receptor ligands and enzyme inhibitors, and the design of photoresponsive drugs all discussed.
Drawing on practical case studies, the hybridization of molecules for development as treatments for a number of key diseases is then outlined, including the design of hybrids for Alzheimer's, cancer, and malaria.
With its cutting-edge reviews of breaking developments in this exciting field, the book offers a novel approach for all those working in the design, development, and administration of drugs for a range of debilitating disorders.
Highlights an approach unimpaired by the limitations of the classical search for lead structures - one of the core problems in modern drug development processes, making the content of high relevance for both academic and non-academic drug development processes
Pulls together research and design techniques in a novel way to give researchers the best possible platform from which to review the approaches and techniques applied
Compares the advantages and disadvantages of these compounds
Includes the very latest developments, such as photoactivatable and photo-responsive drugs
Описание: This thesis addresses the development of a new force spectroscopy tool, correlation force spectroscopy (CFS) for the measurement of the properties of very small volumes of material (molecular to m3) at kHz-MHz frequency range.
Описание: This book highlights the current state-of-the-art regarding the application of applied crystallographic methodologies for understanding, predicting and controlling the transformation from the molecular to crystalline state with the latter exhibiting pre-defined properties.
Автор: Warren D. Seider, Daniel R. Lewin, J. D. Seader, S Название: Product and Process Design Principles: Synthesis, Analysis and Design ISBN: 1119588006 ISBN-13(EAN): 9781119588009 Издательство: Wiley Рейтинг: Цена: 8077.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: These 2010 essays offer a plurality of critical approaches to Kierkegaard`s fundamental text of existential philosophy. They cover hotly debated topics such as the tension between the Socratic-philosophical and the Christian-religious; the identity of Kierkegaard`s pseudonym `Johannes Climacus`; his conceptions of paradoxical faith and of passionate understanding; and his contemporary pertinence.
Описание: This volume presents and discusses the vital precepts underlying the efficient, effective, and cost-effective development of pharmaceutical drug products. It focuses on the adoption of systematic quality principles of pharmaceutical development.
Описание: In today's highly competitive industrial climate, and in times of limited company resources and a continual need to improve company performance in all areas, the use of effective and efficient tools and development methodologies for research and development (R&D) is one interesting avenue to follow. Thus, the question is not really whether they should be deployed or not, but rather which methodologies and best-practices should be used, and why, when and how they should be deployed.Contemporary Quality Function Deployment for Product and Process Innovation: Towards Digital Transformation of Customer and Product Information in a New Knowledge-Based Approach introduces the reader to the industrial use of the Quality Function Development (QFD) methodology in product and process innovation. Customer, product, and production data related to each product family will be digitized in the matrix structures used in this methodology, and be made accessible, more transparent, and visible, thus facilitating a holistic product information perspective. Moreover, using this information in the creation of Integrated Knowledge Platforms (IKPs), supporting more digitalized product and process innovation work processes, will speed up product development and capture vital information to be used in your next-generation product innovation projects. From an overall company perspective, the well-proven ability of the QFD methodology to stimulate cross-functional product innovation will guide product innovation towards a new knowledge-based approach in its enhanced digital transformation and use of integrated customer, product, and production informationUsing the QFD methodology, you will learn how to create a retrievable and accumulated digitized company knowledge base, coupled with improved company communication. You will get better decision support, assisting in the development of better product specifications, and resulting in better products, and ultimately leading to improved customer satisfaction. The adoption of the QFD tool and matrices in building such well-structured knowledge-based platforms (IKPs) related to individual products or product families is the heart of the matter and the 'hidden gem' of QFD methodology use.The book aims to serve as a manual introducing the methodology and how to use it, offering a guiding framework, and being a handbook for the methodology's industrial use for both newcomers and product developers. Furthermore, it offers new perspectives on a more efficient and effective use of the QFD methodology for the seasoned practitioner. This book can also serve as a textbook for students in all disciplines of the natural sciences, innovation management, product design, and engineering. Each part of the book concludes with a number of questions that can be used as learning instruments in lecturing and for more advanced tutorials.
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