Advanced Glycation End-Products: Sources and Effects 9781536175479

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Автор: Patrik Bast
Название: Advanced Glycation End-Products: Sources and Effects
ISBN: 9781536175479
Издательство: Nova Science
Классификация:

Биохимия

ISBN-10: 1536175471
Обложка/Формат: Paperback
Страницы: 144
Вес: 0.23 кг.
Дата издания: 25.03.2020
Серия: Biology
Язык: English
Размер: 139 x 209 x 32
Читательская аудитория: Professional & vocational
Ключевые слова: Biochemistry
Подзаголовок: Sources and effects
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Поставляется из: Англии
Описание: Advanced Glycation End-Products: Sources and Effects attempts to describe the role of advanced glycation end-products, particularly dietary advanced glycation end-products, in the pathological expansion of adipose tissue as well as their implications in the development of obesity associated complications. The effects of advanced glycation end-products on vasculature and their pathological implications are also described, focusing on the epigenetic mechanisms (particularly that of miRNA) modulating their effects. The authors summarize the information available on the impact of hyperglycemia on the influencing factors of non-enzymatic glycosylation, the formation of advanced glycation end-products, and the role of advanced glycation end-products and their specific receptors in diabetes. The role of advanced glycation end-products to diabetic complications is examined in conjunction with the protective role of the endogenous secretory receptor for advanced glycation end-products (esRAGE) and the therapeutic interveentions that would mimic esRAGE activity. In closing, poly-L-lysine modified with advanced glycation end-products is prepared and used as an antigen to generate a single-chain fragment variable monoclonal antibody (scFv mAb) through phage display technology.

Advanced Glycation End-Products: Sources and Effects, Patrik Bast