Автор: Aschner Michael, Costa Lucio G. Название: Neurotoxicity of Metals: Old Issues and New Developments, 5 ISBN: 0128237759 ISBN-13(EAN): 9780128237755 Издательство: Elsevier Science Рейтинг: Цена: 25265.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
The volume discusses novel issues associated with the neurotoxicity of select metals
Автор: Richard M. Kostrzewa Название: Handbook of Neurotoxicity ISBN: 1461458358 ISBN-13(EAN): 9781461458357 Издательство: Springer Рейтинг: Цена: 69738.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Here is an instructive and valuable guide towards understanding the role of neurotoxins/neurotoxicity in the expansive field of Neuroscience. It is an indispensable tool for laboratory investigators, neuroscientists, and clinical researchers.
Автор: Qiao Niu Название: Neurotoxicity of Aluminum ISBN: 9811313695 ISBN-13(EAN): 9789811313691 Издательство: Springer Рейтинг: Цена: 16070.00 р. Наличие на складе: Поставка под заказ.
Описание: This book reviews the scientific literature and the authors’ own research linking aluminum neurotoxicity with cognitive impairment and Alzheimer’s disease (AD). It focuses on aluminum levels in the brain, region-specific and subcellular distribution, and its relation to neurofibrillary tangles and amyloid beta. Further, the book stresses the importance of aluminum’s complex speciation chemistry in relation to biology, and details aluminum’s mechanism in oxidative stress and cell death, especially in connection with apoptosis and necroptosis. The electrophysiological variation and synaptic plasticity induced by aluminum are covered, while the metal’s debatable role in AD and the cross-talk between aluminum and genetic susceptibility are also discussed. In closing, the book reviews the neurotoxic effects of aluminum and its important role in the pathogenesis of AD. Given its depth of coverage, the book provides readers with a systematic summary of aluminum neurotoxicity.
Автор: C. Winder Название: The Developmental Neurotoxicity of Lead ISBN: 9401089663 ISBN-13(EAN): 9789401089661 Издательство: Springer Рейтинг: Цена: 12157.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Over the past two millennia environmental lead levels have risen dramatically (Patterson, 1980). Beginning in the late 1960s, evidence began to accumulate suggesting that lead at relatively low levels of exposure might be causing negative effects on neurobiological function.
Автор: Jos? M. Fuentes Название: Toxicity and Autophagy in Neurodegenerative Disorders ISBN: 3319382128 ISBN-13(EAN): 9783319382128 Издательство: Springer Рейтинг: Цена: 18284.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Comprehensive overview of different aspects of autophagy as it relates to neurodegenerative diseases. Topics include: the role of autophagy in the brain, the role of autophagy in the principal neurodegenerative disorders, and the mechanism by which different molecules cause neurotoxicity and the role autophagy plays.
Автор: Lucyna Antkiewicz-Michaluk; Hans Rommelspacher Название: Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants ISBN: 1489987541 ISBN-13(EAN): 9781489987549 Издательство: Springer Рейтинг: Цена: 26120.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book reports, for the first time, results from behavioral, neurochemical and molecular experiments which demonstrate a range of TIQs and BCs effects - from their rather mild neurotoxic actions to the important neuroprotective and antiaddictive properties.
Автор: Jiang, Xinguo Название: Neurotoxicity of Nanomaterials and Nanomedicine ISBN: 0128045981 ISBN-13(EAN): 9780128045985 Издательство: Elsevier Science Рейтинг: Цена: 17517.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Neurotoxicity of Nanomaterials and Nanomedicine presents an overview of the exciting research in neurotoxicity and nanomaterials. Nanomaterials have been extensively used in medicine, including diagnosis probes, drug carriers, and embedded materials. While some have been approved for clinical use, most nanomaterials are waiting to be transferred from lab to clinic. However, the toxicity is a main barrier that restricts the translation. . This comprehensive book includes chapters on the most commonly used individual nanoparticles, with information on the applications, neurotoxicity, and related mechanisms of each, providing the most in-depth and current information available. The book examines the pathways that nanomaterials enter into, and eliminate, from the brain, along with the strategies that could reduce the neurotoxicity of nanomaterials. . Providing a background to the subject, detailed information, and ideas for future directions in research, the book is essential for students and researchers in toxicology, and for those in medicine, neurology, pharmacology, pharmaceutical science, and materials science who are researching nanomaterials.
Автор: Norbert M?ller; Aye-Mu Myint; Markus J. Schwarz Название: Immunology and Psychiatry ISBN: 3319136011 ISBN-13(EAN): 9783319136011 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Psychiatric disorders are one of the most dramatic burdens for humankind. The role of immune dysfunction in the pathophysiology of these disorders has emerged during the last years, because there has been tremendous progress in psychoneuroimmunological research. Many results are presented here by pioneers in the field. The book addresses various effects of the immune system on the pathophysiology and course of psychiatric disorders and highlights the possible future impact on treatment decisions of various psychiatric disorders, including schizophrenia and depression. The contributions cover the role of in utero immune challenges on the development of schizophrenia, the role of infections, and autoimmune diseases and mild immune activation in the development of depression and schizophrenia, the influence of immune responses in other disorders such as Tourette's, Alzheimer's, and OCD, the connections between mental and physical pain as well as between anti-inflammatory and antipsychotic drugs.
Автор: Jolanta B. Zawilska Название: Synthetic Cathinones ISBN: 3030087697 ISBN-13(EAN): 9783030087692 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Over the last decade, and particularly during the recent five years, a rapidly increasing number of novel psychoactive substance (NPSs), often marketed as “designer drugs”, “legal highs”, “herbal highs”, “research or intermediate chemicals” and “laboratory reagents”, has appeared on the drug market in an effort to bypass controlled substance legislation. NPSs encompass a wide range of different compounds and drug classes but had been dominated by synthetic cannabinomimetics and psychostimulatory synthetic cathinones, so-called ?-keto amphetamines. Compounds from the later class were first detected in Europe in 2004, and since then 103 new cathinones have been identified and reported to the European Monitoring Centre for Drugs and Drug Addiction, with 57 during the last two years. Synthetic cathinones – novel addictive and stimulatory psychoactive substances is the first publication of this kind that provides readers with background on chemical structures, detection, prevalence and motivation of use of the very popular group of NPSs. This book also presents comprehensive overview of the mechanisms of action, pharmacological activity, and main metabolic pathways of synthetic cathinones, followed by a detailed discussion of the acute and chronic toxicity associated with the use of these substances. Written by international experts in the field, this multi-authored book is a valuable reference not only for scientists, clinicians and academics, but also for readers representing different professional background who are involved in educational-prophylactic activities directed to harm reduction of psychoactive compounds.
Автор: Micaela Morelli; Nicola Simola; Jadwiga Wardas Название: The Adenosinergic System ISBN: 3319202723 ISBN-13(EAN): 9783319202723 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Adenosine A2A receptors: localization and function.- Allosteric Mechanisms in the adenosine A2A-dopamine D2 receptor heteromer.- Adenosine A2A receptor antagonists in drug development.- Adenosine A2A Receptors and Neurotrophic Factors: Relevance for Parkinson's Disease.- Role of adenosine A2A receptors in the control of neuroinflammation - relevance for Parkinson's disease.- Purines in Parkinson's: Adenosine A2A receptors and urate as targets for neuroprotection.- Adenosine A2A receptor antagonists as drugs for symptomatic control of Parkinson's disease in preclinical studies.- Dopamine/adenosine interactions related to tremor in animal models of Parkinsonism.- Adenosine A2A receptor antagonists in L-DOPA-induced motor fluctuations.- Adenosine A2A receptor-mediated control of non-motor functions in Parkinson's disease.- Imaging Studies with A2A Receptor Antagonists.- Caffeine and neuroprotection in Parkinson's disease.- The story of istradefylline - the first approved A2A antagonist for the treatment of Parkinson's disease.- Adenosinergic Receptor Antagonists: Clinical Experience in Parkinson's Disease.- Adenosinergic regulation of sleep-wake behavior in the basal ganglia.
Автор: Michael Aschner; Lucio G. Costa Название: Neurotoxicity of Metals ISBN: 3319868004 ISBN-13(EAN): 9783319868004 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Поставка под заказ.
Описание: Assembles international authorities to address contemporary research in metal neurotoxicity. Few books or periodicals have been wholly dedicated to the topic of metals, and this collection is intended to serve as a resource for all researchers interested in metals and their role in health and disease.
Автор: Agrawal Название: Medicinal Herbs and Fungi ISBN: 9813341432 ISBN-13(EAN): 9789813341432 Издательство: Springer Рейтинг: Цена: 34937.00 р. Наличие на складе: Поставка под заказ.
Описание: The ever-rising increase in the consumption of medicinal herbs and its products and its exposure in the human population have generated concerns about the potential neurotoxicity of several new and existing botanicals.
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