Handbook of Pharmacokinetic/Pharmacodynamic Correlation,
Автор: Randall J. Mrsny, Ann Daugherty Название: Proteins and Peptides: Pharmacokinetic, Pharmacodynamic, and Metabolic Outcomes ISBN: 1420078062 ISBN-13(EAN): 9781420078060 Издательство: Taylor&Francis Рейтинг: Цена: 19293.00 р. 27562.00-30% Наличие на складе: Есть (1 шт.) Описание: Addressing the increased use of protein and peptide candidates as treatments for previously untreatable diseases, this comprehensive and progressive source provides the reader with a roadmap to an increased understanding of issues critical for successfully developing a protein or peptide therapeutic candidate. Proteins and Peptides is an invaluable source for drug discovery and development scientists in the biopharmaceutical industry who frequently navigate the maze of protein and peptide pharmacokinetics, pharmacodynamics, and metabolism.
Key features include:
issues related to delivery of protein and peptide therapeutics in elderly populations and pharmacogenomics
lessons learned on the major marketed areas of proteins and peptides, including interleukins, interferons, growth factors, and peptide hormones
innovations for protein and peptide delivery such as needle-less delivery
strategies for delivery of these molecules to locations such as the eye and brain
Описание: In Uganda, East Africa, a region long controlled by Joseph Kony`s Lord`s Resistance Army, leaders of Catholic, Protestant, and Muslim communities overcame centuries of mistrust to work together for peace. Drawing on a rich collection of personal interviews, David Hoekema recounts the courageous work of the Acholi Religious Leaders` Peace Initiative to resolve the conflict and rebuild communities.
Автор: Peter L. Bonate Название: Pharmacokinetic-Pharmacodynamic Modeling and Simulation ISBN: 1489973869 ISBN-13(EAN): 9781489973863 Издательство: Springer Рейтинг: Цена: 23058.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The second edition of the book therefore considerably expands with the addition of three new chapters relating to Bayesian models, Generalized linear and nonlinear mixed effects models, and Principles of simulation.
Описание: This comprehensive review provides a systematic, unbiased analysis, critique and summary of the available literature and generates novel clinical decision-making algorithms which can aid clinicians and scientists in practice management and research development. Potential mechanisms for the identified drug interactions are deduced from available preclinical and in vitro data which are interpreted in the context of the in vivo findings. Current limitations and gaps in the literature are summarized, and potential future research directions / experimentations are also suggested. In addition to the main objective to review the available clinical pharmacokinetic and pharmacodynamic drug interactions associated with WHO-recommended antimalarial drugs on the market today (i.e. chloroquine, amodiaquine, sulfadoxine, pyrimethamine, mefloquine, artemisinin, artemether, artesunate, dihydroartemisinin, artemotil, lumefantrine, primaquine, atovaquone, proguanil, piperaquine and quinine), this book also provides succinct chapter summaries on the epidemiology of malaria infection, diagnosis and therapeutics, in vivo pharmacology and chemistry, preclinical pharmacology, in vitro pharmacodynamics, in vitro reaction phenotyping, and in vitro drug-drug interaction data associated with the identified antimalarial drugs.
Описание: Advanced Methods of Pharmacokinetic and Pharmocodynamic Systems Analysis Volume 3 is vital to professionals and academicians working in drug development and bioengineering.
Описание: In the pharmaceutical industry, the incorporation of the disciplines of pharma- kinetics, pharmacodynamics, and drug metabolism (PK/PD/DM) into various drug development processes has been recognized to be extremely important for approp- ate compound selection and optimization.
Описание: Introduction.- Pharmacology of Recommended Antimalarial Agents.- Drug Interaction Potential of Antimalarial Drugs Based on Known Metabolic Properties of Antimalarials.- Pharmacokinetic Drug Interactions Affecting Antimalarials.- Effects of Antimalarials on the Pharmacokinetics of Co-Administered Drugs.- Effects of Antimalarials on the Pharmacokinetics of Co-Administered Antimalarials.- Pharmacodynamic Interactions: Clinical Evidence for Combination Therapy, In Vitro Interactions, and In Vivo Interactions.- Limitations, Future Directions, and Conclusions.
Описание: Providing more than just a comprehensive history, critical vocabulary, insightful compilation of motivations, and clear explanation of the state-of-the-art of modern clinical trial simulation, this book supplies a rigorous framework for employing simulation as an experiment, according to a predefined simulation plan, that reflects good simulation practices. The book discusses how to design clinical trials according to their probability for success, techniques to define distributions of virtual subjects' characteristics, methods to determine the sensitivity of the trial design, and the population relationship between dosing schedules and patient response.
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