Описание: Stop memory loss. Improve cognitive function. Prevent Alzheimer`s and dementia. Give your brain health a boost with the 30-Minute Brain Diet Protocol now!
Автор: R. Besser; Louis R. Caplan; G. Kr?mer; Hanns C. Ho Название: Brain-Stem Localization and Function ISBN: 3642781748 ISBN-13(EAN): 9783642781742 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The brain stem and cerebellum are structures that have fascinated and puzzled physicians, anatomists, and physio- logists for centuries. Relatively small in volume compared to the much larger and more majestic human cerebrum, and hidden away in relative obscurity in the back of the head under the protection of the bony posterior fossa and the firm dural envelope, the tentorium cerebelli, these critical neural structures defied precise study during life until very recently. Recent advances in brain and vascular imaging and improved understanding of brain-stem reflex and tract functions and their measurement by electrophysiological techniques have presented an opportunity for clinicians and researchers to better study, during life, patients with stroke and other conditions that involve the brain stem and cere- bellum. A congress was held at the Neurology Clinic of the University in Mainz, April 4-5, 1992, during which clinicians and researchers reported and discussed modern topical diagnosis of diseases of the brain stem and cere- bellum. This volume represents the edited proceedings of that congress. Early information about brain stem anatomy and func- tions came from anatomical studies by Ludwig Turk, Paul Flechsig, Rudolph von K6lliker, Karl Burdach, Vladimir Bekterew, and Benedikt Stilling, among others, all working in Germany during the middle years of the nineteenth century. Johann Reil, a German anatomist, in the begin- ning of the nineteenth century had described the structure and some functions of the cerebellum which he called the little brain ("Kleinhirn").
Автор: Silvia Lores-Arnaiz Название: Brain Mitochondria: Distribution and Function ISBN: 1536166502 ISBN-13(EAN): 9781536166507 Издательство: Nova Science Рейтинг: Цена: 27402.00 р. Наличие на складе: Невозможна поставка.
Описание: "Brain mitochondria: Distribution and Function" offers an overview of significant findings regarding physiological, toxicological and pathological aspects of brain mitochondria properties and their relevant role in cellular bioenergetics. Essential physiological processes such as cell respiration and ATP synthesis, the maintenance of calcium homeostasis, reactive oxygen species generation and apoptotic cell signaling performed by mitochondria are described in the different chapters of this volume. In particular, the importance of specific calcium signaling at synaptic level and its relationship with mitochondrial bioenergetics are extensively described. Being that high energy demands are required at synaptic level for neurotransmission, mitochondrial distribution becomes relevant for essential neuronal processes. Differential bioenergetic characteristics of neuronal, astrocytic and glial mitochondria are discussed. Interestingly, new insights on the interaction between neurotensinergic and nitrergic systems are detailed, based on experimental evidences of the effect of neurotensin receptors blockade on nitric oxide production and mitochondrial function. The chapters describing metal neurotoxicity provide a comprehensive view of the effects of different metals on brain mitochondrial function and their consequences for human health. The impact of iron and copper overload on brain oxidative redox balance and mitochondrial function is fully detailed, focusing on the role of metal-induced neuronal damage on the incidence and progression of neurodegenerative diseases. In addition, a complete revision of the mechanisms underlying heavy metal-mediated damage to brain mitochondria is presented. Neurotoxic effects of arsenic, thallium, lead, cadmium and mercury have been associated with cell bioenergetics impairment, exacerbated production of oxygen free radicals, and induction of intrinsic pathway of apoptosis. Mitochondrial function can also be impaired by treatment with different drugs acting at CNS level. The understanding of the effects of pharmacological agents, abuse drugs, herbicides and insecticides at mitochondrial level can contribute to elucidate the molecular mechanisms involved in neurodegeneration. In this context, the neuroprotective effect of different compounds targeting mitochondrial integrity and function is discussed. Furthermore, mitochondrial alterations, oxygen radicals generation and nitric oxide production are characterized in relation to CNS pathology and hypoxia conditions. Mitochondrial complex I inactivation, oxidative stress and impairment of mitochondrial nitric oxide synthesis are characteristic features of the mitochondrial dysfunction observed in Parkinsons disease and other CNS pathologies. In addition, exposure to hypoxic conditions can affect nitric oxide generation and mitochondrial physiology, with different responses depending on the brain area. As a whole, the understanding of the alterations in mitochondrial distribution and function in the brain associated with neurotoxicity and neurodegeneration may contribute to the knowledge of the role of mitochondria in maintaining the balance between health and disease.
Автор: Liliana Letra; Raquel Sei?a Название: Obesity and Brain Function ISBN: 3319875116 ISBN-13(EAN): 9783319875118 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Поставка под заказ.
Описание: This compendium provides a wide view covering everything from molecular mechanisms and risk factors for neurological disorders to the effects of bariatric surgery on brain function and functional neuroimaging applied to obesity research.
Автор: Santamarнa Enrique, Fernбndez-Irigoyen Joaquнn Название: Current Proteomic Approaches Applied to Brain Function ISBN: 1493983903 ISBN-13(EAN): 9781493983902 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Preface to the Series Preface Table of Contents Contributing Authors
PART I Introduction
1. Brain Proteomics: Decoding Neuroproteomes using Mass-Spectrometry Joaquнn Fernбndez-Irigoyen and Enrique Santamarнa
PART II Labeling Methods in Neuroproteomics
2. Applications of Amine-Reactive Tandem Mass Tags (TMT) in Human Neuroproteomics Linnйa Lagerstedt, Leire Azurmendi, and Jean-Charles Sanchez
3. Application of Isobaric Tags for Relative and Absolute Quantitation (iTRAQ) to Monitor Olfactory Proteomes during Alzheimer s Disease Progression Andrea Gonzбlez-Morales, Mercedes Lachйn-Montes, Marнa Ibaсez-Vea, Enrique Santamarнa, and Joaquнn Fernбndez-Irigoyen
4. Protein Microarrays in Neurodegenerative Diseases Pablo San Segundo-Acosta, Marнa Garranzo-Asensio, Ana Montero-Calle, Carmen Oeo-Santos, Mayte Villalba, Ana Guzmбn-Arбnguez, and Rodrigo Barderas
PART III Label-Free Methods in Neuroproteomics
5. Comprehensive Shotgun Proteomic Analyses of Oligodendrocytes using Ion Mobility and Data Independent Acquisition Juliana S. Cassoli and Daniel Martins-de-Souza
6. Non-Targeted Brain Lipidomics Profiling Performed by UPLC-ESI-qTOF-MS/MS Alba Naudн, Rosanna Cabrй, Mariona Jovй, and Reinald Pamplona
7. Methods for Human Olfactory Bulb-Tissue Studies using Peptide/Protein MALDI-TOF Imaging Mass Spectrometry (MALDI-IMS) Ibon Iloro, Joaquнn Fernбndez-Irigoyen, Iraide Escobes, Mikel Azkargorta, Enrique Santamarнa, Felix Elortza
8. Neuroproteomics using Short GeLC-SWATH: From the Evaluation of Proteome Changes to the Clarification of Protein Function Sandra I. Anjo, Cбtia Santa, Susana C. Saraiva, Karolina Freitas, Faraj Barah, Bruno Carreira, Inкs Araъjo, and Bruno Manadas
PART IV Mass Spectrometry-based Neuroproteomics to Analyze Post-Translational Modificiations
9. Analysis of Brain Phosphoproteome using Titanium Dioxide Enrichment and High Resolution LC-MS/MS Jeffrey M. Sifford, Haiyan Tan, Hong Wang, and Junmin Peng
10. N-Glycomics and N-Glycoproteomics of Human Cerebrospinal Fluid Sophie Cholet, Arnaud Goyallon, Christophe Junot, and Franзois Fenaille
11. In Vivo Strategies to Isolate and Characterize the Neuronal Ubiquitinated Proteome Juanma Ramнrez, Nagore Elu, Aitor Martinez, Benoit Lectez, and Ugo Mayor
12. Characterization of the Phosphoproteome and Sialoproteome in Brain Tissues by Mass Spectrometry Marнa Ibaсez-Vea, Stefan J. Kempf, and Martin R. Larsen
13. Proteomic Analysis of SUMOylation in the Post-Ischemic Brain J. Will Thompson, Meng Jiang, and Wei Yang
14. S-Nitrosylation in Alzheimer s Disease using Oxidized Cysteine-Selective cPILOT Ryan R. Dyer, Liqing Gu, and Renг A.S. Robinson
PART V Subcellular Neuroproteomics
15. Proteomic Analysis of Extracellular Vesicles in Neurological Diseases Matнas Sбenz-Cuesta, Enrique Santamarнa, Joaquнn Fernбndez-Irigoyen, and David Otaegui
16. Quantitative In-Depth Profiling of the Postsynaptic Density Proteome to Understand the Molecular Mechanisms Governing Synaptic Physiology and Pathology Rita Reig-Viader and Alex Bayйs
17. Nuclear Proteomics for Exploring MK-801 Treated Oligodendrocytes to Better Understand Schizophrenia Aline G. Santana, Giuliana S. Zuccoli, Verфnica Saia-Cereda, Juliana S. Cassoli, and Daniel Martins-de-Souza
18. Localized Proteomics of Individual Neurons Isolated from Formalin-Fixed, Para
Автор: Barnes Название: Brain-gut Peptides and Reproductive Function ISBN: 0849388481 ISBN-13(EAN): 9780849388484 Издательство: Taylor&Francis Рейтинг: Цена: 33686.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book elucidates the role of brain-gut peptides in neuroendocrine regulation for understanding how these peptides interact with the reproductive neuroendocrine axis and for developing novel therapeutic agents for fertility or contraceptive therapies.
Описание: This book provides an up-to-date overview of the role of neurosteroids and neuroactive steroids in the regulation of brain processes and neuropsychiatric disorders. It addresses the neurosteroid function in brain development and plasticity, in both the normal and the pathological brain.
Автор: Abel, Ted Название: Sleep, neuronal plasticity and brain function ISBN: 3662468778 ISBN-13(EAN): 9783662468777 Издательство: Springer Рейтинг: Цена: 30745.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book reviews current knowledge on the importance of sleep for brain function, from molecular mechanisms to behavioral output, with special emphasis on the question of how sleep and sleep loss ultimately affect cognition and mood. It provides an extensive overview of the latest insights in the role of sleep in regulating gene expression, synaptic plasticity and neurogenesis and how that in turn is linked to learning and memory processes. In addition, readers will learn about the potential clinical implications of insufficient sleep and discover how chronically restricted or disrupted sleep may contribute to age-related cognitive decline and the development of psychiatric disorders such as schizophrenia and depression. The book consists of 19 chapters, written by experts in basic sleep research and sleep medicine, which together cover a wide range of topics on the importance of sleep and consequences of sleep disruption. This book will be of interest to students, researchers and clinicians with a general interest in brain function or a specific interest in sleep.
An introduction to the brain's anatomical organization and functions with explanations in terms of evolutionary adaptations and development.
This introduction to the structure of the central nervous system demonstrates that the best way to learn how the brain is put together is to understand something about why. It explains why the brain is put together as it is by describing basic functions and key aspects of its evolution and development. This approach makes the structure of the brain and spinal cord more comprehensible as well as more interesting and memorable. The book offers a detailed outline of the neuroanatomy of vertebrates, especially mammals, that equips students for further explorations of the field.
Gaining familiarity with neuroanatomy requires multiple exposures to the material with many incremental additions and reviews. Thus the early chapters of this book tell the story of the brain's origins in a first run-through of the entire system; this is followed by other such surveys in succeeding chapters, each from a different angle. The book proceeds from basic aspects of nerve cells and their physiology to the evolutionary beginnings of the nervous system to differentiation and development, motor and sensory systems, and the structure and function of the main parts of the brain. Along the way, it makes enlightening connections to evolutionary history and individual development. Brain Structure and Its Origins can be used for advanced undergraduate or beginning graduate classes in neuroscience, biology, psychology, and related fields, or as a reference for researchers and others who want to know more about the brain.
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