This unique advanced textbook provides a clear and comprehensive overview of gene delivery, gene therapy and genetic pharmacology, with descriptions of the main gene transfer vectors and a set of selected therapeutic applications, along with safety considerations. The second edition features new groundbreaking material on genome editing using the recently discovered CRISPR/Cas9 system and on cancer immunotherapy by CAR-T cells. It also presents the historical milestone of gene therapy application in the field of severe combined immunodeficiency, and other fields of gene therapy and molecular medicine.
The use of gene transfer is exponentially growing in the scientific and medical communities for day-to-day cell biology experiments and swift development of gene therapy, which is already revolutionizing medicine. In this advanced textbook, more than 30 leading scientists come together to explore these topics.
This educational introduction provides the background material needed to further explore the subject as well as relevant research literature. It is an invaluable resource to Master, PhD or MD students, post-doctoral scientists or medical doctors, as well as any scientist wishing to deliver a gene or synthetic nucleotide or develop a gene therapy strategy. The second edition's simple and synthetic content will be of value to any reader interested in the biological and medical revolution derived from the elucidation of the human genome.
Автор: Charles R. Schuster; Michael J. Kuhar Название: Pharmacological Aspects of Drug Dependence ISBN: 364264631X ISBN-13(EAN): 9783642646317 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: With contributions by numerous experts
Автор: N. Allon; S. Shapira; B.A. Weissman Название: Biochemical, Pharmacological, and Clinical Aspects of Nitric Oxide ISBN: 1461357772 ISBN-13(EAN): 9781461357773 Издательство: Springer Рейтинг: Цена: 15672.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A decade ago, for most scientists investigating various issues in life sciences the word "NO" was used in a negative context. NO is implicated in long-term potentiation (LPT), a principal process involved in memory consolidation and it is considered as the main biochemical substance responsible for penile erection.
Описание: Few pathologie phenomena, as shock, can originate from so many causes and involve so many complex physiologie mechanisms: The complexity of the phenomenon, thus, has resulted in extensive study and raised many uncertainties.
Автор: R. E. Beamish; V. Panagia; Naranjan S. Dhalla Название: Pharmacological Aspects of Heart Disease ISBN: 0898388678 ISBN-13(EAN): 9780898388671 Издательство: Springer Рейтинг: Цена: 34799.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of an International Symposium on Heart Metabolism in Health and Disease and the 3rd Annual Cardiology Symposium of the University of Manitoba July 8-11, 1986, Winnipeg, Canada
Автор: V.E. Andreucci; Antonia Dal Canton Название: Diuretics: Basic, Pharmacological, and Clinical Aspects ISBN: 0898388856 ISBN-13(EAN): 9780898388855 Издательство: Springer Рейтинг: Цена: 44582.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of the International Meeting on Diuretics, Sorrento, Italy, May 26-30, 1986
Автор: V.E. Andreucci; Antonia Dal Canton Название: Diuretics: Basic, Pharmacological, and Clinical Aspects ISBN: 1461292271 ISBN-13(EAN): 9781461292272 Издательство: Springer Рейтинг: Цена: 44582.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of the International Meeting on Diuretics, Sorrento, Italy, May 26-30, 1986
Автор: R. E. Beamish; V. Panagia; Naranjan S. Dhalla Название: Pharmacological Aspects of Heart Disease ISBN: 1461292220 ISBN-13(EAN): 9781461292227 Издательство: Springer Рейтинг: Цена: 34799.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of an International Symposium on Heart Metabolism in Health and Disease and the 3rd Annual Cardiology Symposium of the University of Manitoba July 8-11, 1986, Winnipeg, Canada
Автор: L.A.A. Ooms; A.D. Degryse; A.S.J.P.A.M. van Miert Название: Physiological and Pharmacological Aspects of the Reticulo-Rumen ISBN: 9401079900 ISBN-13(EAN): 9789401079907 Издательство: Springer Рейтинг: Цена: 12157.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This workshop was organized and convened in an attempt to strengthen the basic science of the ruminant stomach, as it applies to an economically important group of mammals.
Описание: Das Buch enthalt Kapitel uber: M. Azria, Basel, CH: "Calcitonin - Physiologische und Pharmakologische Aspekte"U. Niemeyer, J. Engel, P. Hilgard, M. Peukert, J. Pohl, H. Sindermann, Bielefeld, FRG: "Mafosfamid - Ein Derivat des " "4-Hydroxycyclophosphamids"S. Grunwald, G.P. Pfeifer, Frankfurt, FRG: "Enzymatische DNA Methylierung"
Автор: T. Godfraind; G. Mancia; M.P. Abbracchio; L. Aguil Название: Pharmacological Control of Calcium and Potassium Homeostasis ISBN: 9401040567 ISBN-13(EAN): 9789401040563 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: As the number of drugs acting on calcium and potassium channels grows, there is a need for a continuous reappraisal of the cellular machinery controlling them. Calcium homeostasis within the cell is not only regulated by calcium channels;
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