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Peptide and Protein Drug Analysis, 


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Название:  Peptide and Protein Drug Analysis
ISBN: 9780367399269
Издательство: Taylor&Francis
Классификация:


ISBN-10: 0367399261
Обложка/Формат: Paperback
Страницы: 904
Вес: 1.67 кг.
Дата издания: 27.09.2019
Язык: English
Размер: 252 x 178 x 41
Читательская аудитория: Tertiary education (us: college)
Основная тема: Drug Design & Development
Ссылка на Издательство: Link
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Поставляется из: Европейский союз
Описание:

Furthering efforts to simulate the potency and specificity exhibited by peptides and proteins in healthy cells, this remarkable reference supplies pharmaceutical scientists with a wealth of techniques for tapping the enormous therapeutic potential of these molecules-providing a solid basis of knowledge for new drug design.
Provides a broad, comprehensive overview of peptides and proteins as mediators of cell movement, proliferation, differentiation, and communication.
Written by more than 50 leading international authorities, Peptides and Protein Drug Analysis

  • discusses strategies for dealing with the complexity of peptides and proteins in conformational flexibility and amino acid sequence variability
  • analyzes drug formulations facilitated by solid-phase peptide synthesis and recombinant DNA technology
  • examines chemical purity analysis by high-pressure chromatographic, capillary electrophoretic, gel electrophoretic, and isoelectric focusing methods
  • highlights drug design elements derived from protein folding, bioinformatics, and computational chemistry
  • demonstrates uses of unnatural mutagenesis and combinatorial chemistry
  • explores mass spectrometry, protein sequence, and carbohydrate analysis
  • illustrates bioassays and other new functional analysis methods
  • surveys spectroscopic techniques such as ultraviolet, fluorescence, Fourier transform infrared, and nuclear magnetic resonance (NMR)
  • addresses ways of distinguishing between levels of therapeutic and endogenous agents in cells
  • reviews structural analysis tools such as ultracentrifugation and light, X-ray, and neutron scattering
  • and more!
    Featuring over 3400 bibliographic citations and more than 500 tables, equations, and illustrations, Peptide and Protein Drug Analysis is a must-read resource for pharmacists; pharmacologists; analytical, organic, and pharmaceutical chemis



  • Peptide and Protein Delivery,

    Автор: Chris Van Der Walle
    Название: Peptide and Protein Delivery,
    ISBN: 0123849357 ISBN-13(EAN): 9780123849359
    Издательство: Elsevier Science
    Рейтинг:
    Цена: 20379.00 р.
    Наличие на складе: Поставка под заказ.

    Описание: The growing area of peptide and protein therapeutics research is of paramount importance to medical application and advancement. This title addresses the routes for delivery of therapeutics. It covers cerebral delivery, pulmonary delivery, transdermal delivery, intestinal delivery, ocular delivery, parenteral delivery, and nasal delivery.

    Stability and Characterization of Protein and Peptide Drugs

    Автор: Rodney Pearlman; Y. John Wang
    Название: Stability and Characterization of Protein and Peptide Drugs
    ISBN: 148991238X ISBN-13(EAN): 9781489912381
    Издательство: Springer
    Рейтинг:
    Цена: 28734.00 р.
    Наличие на складе: Есть у поставщика Поставка под заказ.

    Peptide and Protein Engineering

    Автор: Olga Iranzo; Ana Cec?lia Roque
    Название: Peptide and Protein Engineering
    ISBN: 1071607197 ISBN-13(EAN): 9781071607190
    Издательство: Springer
    Рейтинг:
    Цена: 18167.00 р.
    Наличие на складе: Поставка под заказ.

    Описание: It opens with a section on chemical tools applied to the production or engineering of peptides and proteins, and concludes with a collection of chapters on biological approaches used to engineer structure and function in peptides and proteins.

    Peptide and Protein Interaction with Membrane Systems

    Автор: Sara Bobone
    Название: Peptide and Protein Interaction with Membrane Systems
    ISBN: 3319064339 ISBN-13(EAN): 9783319064338
    Издательство: Springer
    Рейтинг:
    Цена: 18167.00 р.
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    Описание: In her thesis, Sara Bobone outlines spectroscopic studies of antimicrobial peptides (AMPs) which are promising lead compounds for drugs used to fight multidrug resistant bacteria.

    Peptide and Protein Interaction with Membrane Systems

    Автор: Sara Bobone
    Название: Peptide and Protein Interaction with Membrane Systems
    ISBN: 331938273X ISBN-13(EAN): 9783319382739
    Издательство: Springer
    Рейтинг:
    Цена: 13059.00 р.
    Наличие на складе: Есть у поставщика Поставка под заказ.

    Описание: In her thesis, Sara Bobone outlines spectroscopic studies of antimicrobial peptides (AMPs) which are promising lead compounds for drugs used to fight multidrug resistant bacteria.

    Stability and Characterization of Protein and Peptide Drugs

    Автор: Rodney Pearlman; Y. John Wang
    Название: Stability and Characterization of Protein and Peptide Drugs
    ISBN: 0306443651 ISBN-13(EAN): 9780306443657
    Издательство: Springer
    Рейтинг:
    Цена: 30039.00 р.
    Наличие на складе: Есть у поставщика Поставка под заказ.

    Описание: This volume attemptsto provide the formulation scientist with casehistories involving the use of therapeutic proteins and peptides that have been mar- keted or are under clinical testing. In previous volumes of this series, funda- mental theories and principles ofprotein characterization and stability were presented in depth by researchers in their fieldsofexpertise. The way from theory to practice isnot alwaysobvious and straightforward. There isa need for practical examples of how the principles and theories are put into use, specificallyin the development of a pharmaceutical product. It is our hope that this volume will fulfillsuch a need. Itisnot asimple task to choose a panel ofproteinsand peptides from the over 200 agents in human clinical trials. We have tried to collect a wide representation of molecules of different sizes-from 10 amino acids (Leu- prolide) to 1020 amino acids (Muromonab CD3). The examples include agents derived from various sources including monoclonal antibodies (Mur- omonab CD3), recombinant DNA (human and bovine growth hormones), natural source (fibrolase), and chemical synthesis (Leuprolide). Clearly this list is not intended to be encyclopedic. It isthe first time a collection of this sort has been made accessibleto the formulation scientists involved in devel- oping protein and peptide products. Although each chapter in this volume focuses primarily on the charac- terization and stability of a specific molecule, each has unique aspects.

    Zebrafish: A Model for Marine Peptide Based Drug Screening

    Автор: Saravanan Ramachandran; Senthilkumar Rajagopal
    Название: Zebrafish: A Model for Marine Peptide Based Drug Screening
    ISBN: 9811378460 ISBN-13(EAN): 9789811378461
    Издательство: Springer
    Рейтинг:
    Цена: 13974.00 р.
    Наличие на складе: Поставка под заказ.

    Описание: It also reviews the structure of marine peptides/toxins and the toxicology of peptide secreting cells and cells that respond to these enzymes, and describes the normal and abnormal toxicology of marine peptides in zebrafish models.

    Delivery Systems for Peptide Drugs

    Автор: S.S. Davis; Lisbeth Illum; E. Tomlinson
    Название: Delivery Systems for Peptide Drugs
    ISBN: 1475799624 ISBN-13(EAN): 9781475799620
    Издательство: Springer
    Рейтинг:
    Цена: 27950.00 р.
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    Описание: Unfortunately, the research on delivery systems for peptides and proteins has not kept pace with the rapid progress in biotechnology and, consequently, there are presently few systems that are entirely appropriate for the administration of macromolecular drugs according to complex dosage regimens, (eg intermittent and pulsed therapy).

    Peptide Growth Factors and Their Receptors II

    Автор: Michael B. Sporn; Anita B. Roberts
    Название: Peptide Growth Factors and Their Receptors II
    ISBN: 3642747833 ISBN-13(EAN): 9783642747830
    Издательство: Springer
    Рейтинг:
    Цена: 18167.00 р.
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    Описание: With contributions by numerous experts

    Zebrafish: A Model for Marine Peptide Based Drug Screening

    Автор: Saravanan Ramachandran; Senthilkumar Rajagopal
    Название: Zebrafish: A Model for Marine Peptide Based Drug Screening
    ISBN: 9811378436 ISBN-13(EAN): 9789811378430
    Издательство: Springer
    Рейтинг:
    Цена: 20962.00 р.
    Наличие на складе: Поставка под заказ.

    Описание: This book offers a comprehensive overview of toxicology, highlighting the significance of peptide-based toxins from marine environments. It discusses the principles of protein-carbohydrate and domain-domain interactions to increase our understanding of toxicology in zebrafish models, as well as drug interaction mechanisms and target definition in drug discovery. It also reviews the structure of marine peptides/toxins and the toxicology of peptide secreting cells and cells that respond to these enzymes, and describes the normal and abnormal toxicology of marine peptides in zebrafish models. Offering insights into the field of proteomics, particularly current practice and research models for solving its many riddles, the book also explains the analytical principles of marine protein-protein and protein-carbohydrate interaction in the context of teratogenicity in target identification in peptide- based drug discovery. Lastly, the book methodically examines the preclinical research on marine proteins/peptides.

    Peptide-Based Drug Design

    Автор: Laszlo Otvos
    Название: Peptide-Based Drug Design
    ISBN: 1617378690 ISBN-13(EAN): 9781617378690
    Издательство: Springer
    Рейтинг:
    Цена: 20263.00 р.
    Наличие на складе: Есть у поставщика Поставка под заказ.

    Описание: Due to their high specificity and low toxicity profile, peptides are once more central to the development of new drugs. Comprehensive and up-to-date, this practical volume provides scientists with a clear, concise guide for continuing this vital research.

    Peptide Synthesis

    Автор: Waleed M. Hussein; Mariusz Skwarczynski; Istvan To
    Название: Peptide Synthesis
    ISBN: 1071602268 ISBN-13(EAN): 9781071602263
    Издательство: Springer
    Рейтинг:
    Цена: 18167.00 р.
    Наличие на складе: Поставка под заказ.

    Описание: This book provides a variety of procedures for synthetically producing peptides and their derivatives, ensuring the kind of precision that is of paramount importance for successful synthesis. Numerous techniques relevant to drugs and vaccines are explored, such as conjugation and condensation methodologies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

    Authoritative and practical, Peptide Synthesis: Methods and Protocols serves as an essential guide to the many crucial processes that will allow researchers to efficiently prepare, purify, characterize, and use peptides for chemical, biochemical, and biological studies.

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