Excipient Toxicity and Safety, Weiner, Myra L. , Kotkoskie, Lois A.

Автор: Ajit S Narang, Bristol-Myers Squibb
Название: Excipient Applications in Formulation Design and Drug Delivery
ISBN: 3319202057 ISBN-13(EAN): 9783319202051
Издательство: Springer
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Цена: 26122.00 р.
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Описание: In recent years, emerging trends in the design and development of drug products have indicated ever greater need for integrated characterization of excipients and in-depth understanding of their roles in drug delivery applications.

Автор: Ajit S Narang; Sai H S. Boddu
Название: Excipient Applications in Formulation Design and Drug Delivery
ISBN: 331937107X ISBN-13(EAN): 9783319371078
Издательство: Springer
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Цена: 22201.00 р.
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Описание: In recent years, emerging trends in the design and development of drug products have indicated ever greater need for integrated characterization of excipients and in-depth understanding of their roles in drug delivery applications.

Автор: Eskes Chantra, Whelan Maurice
Название: Validation of Alternative Methods for Toxicity Testing
ISBN: 3319816128 ISBN-13(EAN): 9783319816128
Издательство: Springer
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Цена: 23757.00 р.
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Описание: This book provides information on best practices and new thinking regarding the validation of alternative methods for toxicity testing.

Автор: Li Di
Название: Drug-like Properties
ISBN: 0128010762 ISBN-13(EAN): 9780128010761
Издательство: Elsevier Science
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Цена: 26444.00 р.
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Описание:

Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including solubility and permeability, before exploring how compounds are absorbed, distributed, and metabolized safely and stably. Review chapters provide context and underscore the importance of key concepts such as pharmacokinetics, toxicity, the blood-brain barrier, diagnosing drug limitations, prodrugs, and formulation. Building on those foundations, this thoroughly updated revision covers a wide variety of current methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties for process and product improvement. From conducting key assays for interpretation and structural analysis, the reader learns to implement modification methods and improve each ADME property.

Through valuable case studies, structure-property relationship descriptions, and structure modification strategies, Drug-Like Properties, Second Edition, offers tools and methods for ADME/Tox scientists through all aspects of drug research, discovery, design, development, and optimization.

Автор: Garg, Vinod Kumar
Название: Pharmaceuticals in Aquatic Environments
ISBN: 1032413816 ISBN-13(EAN): 9781032413815
Издательство: Taylor&Francis
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Цена: 23734.00 р.
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Автор: Rodriguez-Merino, Pablo A. (Royal Military Academy Sandhurst, UK)
Название: Exploring Poisonous Plants
ISBN: 1032311371 ISBN-13(EAN): 9781032311371
Издательство: Taylor&Francis
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Цена: 24499.00 р.
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Описание: This volume in the Exploring Medicinal Plants series discusses botanical description, distribution, phytochemical constituents, pharmacological studies, toxic responses, traditional and other potential uses of various poisonous plants.