Автор: Murthy S. Narasimha, Maibach Howard I. Название: Topical Nail Products and Ungual Drug Delivery ISBN: 1439811296 ISBN-13(EAN): 9781439811290 Издательство: Taylor&Francis Рейтинг: Цена: 27562.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Discussing existing techniques, ongoing research, new approaches, and basic concepts in the treatment of nail diseases, Topical Nail Products and Ungual Drug Delivery summarizes the current knowledge and represents a jumping-off point for creating novel techniques of drug delivery across the nail.
A growing area of pharmaceutical research, the search for efficient delivery techniques that can cross the nail barrier has yielded several effective strategies, brought together in this book.
Topics Include
Nail anatomy, physiology, diseases, and treatment
Permeability of the nail plate
Topical nail formulations
Approaches to enhance ungual and trans-ungual drug delivery
In vitro and in vivo models to evaluate topical nail formulations
Nail sampling techniques
Bioengineering of the nail
Trans-ungual iontophoresis
Pharmacokinetics of drugs in the nail apparatus
Onychopharmacokinetics: proposed model insight
Photodynamic therapy of nail diseases
The nail as a surrogate for investigating drug use
Автор: Vinod P. Shah; Howard I. Maibach; John Jenner Название: Topical Drug Bioavailability, Bioequivalence, and Penetration ISBN: 1493938568 ISBN-13(EAN): 9781493938568 Издательство: Springer Рейтинг: Цена: 18284.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This authoritative volume explores advances in the techniques used to measure percutaneous penetration of drugs and chemicals to assess bioavailability and bioequivalence and discusses how they have been used in clinical and scientific investigations.
Автор: Nigel Langley; Bozena Michniak-Kohn; David W. Osbo Название: The Role of Microstructure in Topical Drug Product Development ISBN: 3030173542 ISBN-13(EAN): 9783030173548 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Following the Semi-solid Microstructure Workshop sponsored by BASF and hosted by the Rutgers Center for Dermal Research, a pharmaceutical product development working group was formed. The group, known as the Q3 Working Group, selected the following five areas of focus: Particle/Globule Size and Distribution, Viscosity/Rheology/Spreadability, In Vitro Testing, State of API, State of Excipients. A committee was appointed for each of these five areas. The committees were tasked to review the literature, identify best practices, list experimental details required for an independent lab to duplicate the test, and propose scientific studies that may meaningfully advance this specific area of focus. Each committee has a chair (or co-chairs) that are the lead author(s) of the chapter. The Q3 Working Group members serve as the critical reviewers of each chapter, making suggestions that improve the quality of the document and that make each of the five chapters uniform in scope and content.
Pharmaceutical development scientists that formulate topical products (creams, lotions, gels suspensions, foams, etc) and all the allied raw material suppliers, packaging suppliers, contract laboratories including CROs, CMOs and regulators need access to this book. Overall, the topic of semisolid microstructure is of equal importance to the generic pharmaceutical companies (filing Abbreviated New Drug Applications or ANDAs) and pharmaceutical companies filing New Drug Applications (NDAs). In addition to products applied to the skin, hair, and nails, The Role of Microstructure in Topical Drug Product Development’ crosses over and is essential reading to developers of oral suspensions, ophthalmic ointments and gels, otic suspension, vaginal semisolids and retention enemas.
Автор: Vinod P. Shah; Howard I. Maibach; John Jenner Название: Topical Drug Bioavailability, Bioequivalence, and Penetration ISBN: 1493912887 ISBN-13(EAN): 9781493912889 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This authoritative volume explores advances in the techniques used to measure percutaneous penetration of drugs and chemicals to assess bioavailability and bioequivalence and discusses how they have been used in clinical and scientific investigations. Seven comprehensive sections examine topics including in vitro drug release, topical drugs products, clinical studies, and guidelines and workshop reports, among others. The book also describes how targeted transdermal drug delivery and more sophisticated mathematical modelling can aid in understanding the bioavailability of transdermal drugs. The first edition of this book was an important reference guide for researchers working to define the effectiveness and safety of drugs and chemicals that penetrated the skin. This second edition contains cutting-edge advances in the field and is a key resource to those seeking to define the bioavailability and bioequivalence of percutaneously active compounds to improve scientific and clinical investigation and regulation.
Автор: Langley Nigel, Michniak-Kohn Bozena, Osborne David W. Название: The Role of Microstructure in Topical Drug Product Development ISBN: 3030173577 ISBN-13(EAN): 9783030173579 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
VISCOSITY / RHEOLOGY / SPREADABILITY
Executive Summary / Scope
Chapter focuses on the following aspects of rheological properties of topical semi-solid formulations:
- Analytical instrumentation and techniques to determine rheological properties.
- Factors affecting rheological properties:
o Formulation physical/chemical parameters (i.e., pH, concentration of excipients, excipient combinations, etc.)
o Primary container closures
o Manufacturing/process equipment
- Review of current literature and recommendation on best practices for 1) characterizing the rheological aspects of topical semi-solid formulations during development phase and 2) rotational viscosity methods to ensure product consistency for commercial stage products.
2.2. Why is rheology important for topical semi-solid formulations?
2.2.1. Newtonian systems vs non-Newtonian systems
2.2.2. Raw materials
2.2.3. Formulations
2.2.4. Effect of Processing parameters
2.2.5. Quality Control
2.3. Rheological Test Methods
2.3.1. Continuous shear vs Oscillatory shear
2.4. Instrumentation
2.4.1. Viscometry: Single point vs Multiple point instruments
2.4.2. Rheometry: Controlled stress vs Oscillatory Rheometers
3. Review of current state and outline best practice
3.1. USP chapters 911,912 and 1911 and 1912
3.2. Rheology of different dosage forms
3.2.1. Creams
3.2.2. Ointments
3.2.3. Lotions
3.2.4. Gels
3.2.5. Others (foams, SLN dispersions etc.)
3.3. White papers from instrument manufacturers
3.3.1. Application specific analysis of rheology
3.3.1.1. Effect of temperature on viscosity
3.3.1.2. Effect of shear rate on moduli
3.3.1.3. Determination of yield stress
3.4. Correlation of processing conditions to the rheological data
3.4.1. Speed of mixing
3.4.2. Processing temperature
3.4.3. Others (use of vacuum, presence of nitrogen, mixing type - homogenizers, dispersers, propellers, spindle mixers etc.)
4. Recommendation for next steps
4.1. Identify gaps
4.1.1. Temperature dependent studies
4.1.1.1. What is there to gain by evaluating the rheology of a semi-solid product at temperatures other than its recommended storage condition.
4.1.2. How is viscosity data being used
4.1.2.1. What other variables of product development can viscosity/rheology be evaluated for other than physical stability.
ROLE OF EXCIPIENTS ON THE Q3 (MICROSTRUCTU
Автор: B. Gabard; P. Elsner; C. Surber; P. Treffel Название: Dermatopharmacology of Topical Preparations ISBN: 3642629601 ISBN-13(EAN): 9783642629600 Издательство: Springer Рейтинг: Цена: 18284.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proof of the efficacy of dermatological products is a prerequisite for clinical testing and registration. The authors are recognized specialists in their field and use a standardized approach to the projects facilitating the reading for the stressed scientist, for the R+D managers general view as well as for the beginners in the field.
Автор: Paulson, Daryl S. Название: Topical antimicrobials testing and evaluation ISBN: 036737787X ISBN-13(EAN): 9780367377878 Издательство: Taylor&Francis Рейтинг: Цена: 9798.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
A range of factors must be considered when developing a topical antimicrobial for use in a healthcare personnel handwash, surgical scrub, or preoperative skin preparation. Antimicrobial effectiveness, low skin irritation, ease of use, and pleasing aesthetics are all essential if the product is to succeed. In addition, all facets of the product must comply with stringent regulatory requirements. With updated protocols and research, Topical Antimicrobials Testing and Evaluation, Second Edition comprehensively presents and reviews the latest techniques for testing antimicrobial compounds for effectiveness and regulatory compliance.
Topics include:
The anatomical structure of the skin and skin microbiology relevant to product testing
Use of antimicrobial products against specific microorganisms such as Staphylococcus and Streptococcus species
Measurement of antimicrobial action of topical antimicrobials from experimental design, microbiological, biostatistical, and marketplace perspectives
Various aspects of the topical antimicrobial products currently in common use in medical, food service, and consumer markets
Statistical analysis and specific statistical designs for clinical trials
Epistemological requirements in evaluating the effects of specific treatments
Evaluation strategies and sample working protocols for hand and body soaps, food-handler antimicrobial products, and medical/healthcare industry antimicrobial products
The book is designed to inform industry and academia on the requirements to get products approved by the FDA and to market while also providing critical insight on ways to best service expanding markets.
Автор: Nail Akhmediev; Adrian Ankiewicz Название: Dissipative Solitons: From Optics to Biology and Medicine ISBN: 3642096875 ISBN-13(EAN): 9783642096877 Издательство: Springer Рейтинг: Цена: 14673.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The dissipative soliton concept is a fundamental extension of the concept of solitons in conservative and integrable systems. It includes ideas from three major sources, namely standard soliton theory developed since the 1960s; These three sources also correspond to the three component parts of this novel paradigm.
Автор: Nail Burnashev; Pierre Szepetowski Название: NMDA Receptors ISBN: 1493973207 ISBN-13(EAN): 9781493973200 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume explores the latest techniques used by researchers to help them better understand the NMDAR structure-function relations, principles, and rules that govern how NMDARs operate in brain processing.
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