Inhaled Medicines 9780128149744

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Автор: Kassinos, Stavros
Название: Inhaled Medicines
ISBN: 9780128149744
Издательство: Elsevier Science
Классификация:

Отрасли обрабатывающей промышленности

Фармацевтические производства

Фармакология

ISBN-10: 0128149744
Обложка/Формат: Paperback
Вес: 0.45 кг.
Дата издания: 01.11.2020
Язык: English
Размер: 191 x 234 x 30
Подзаголовок: Optimizing development through integration of in silico, in vitro and in vivo approaches
Ссылка на Издательство: Link
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Поставляется из: Европейский союз
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The inhaled route to deliver drugs to the lungs is widely accepted for treatment of lung diseases, and has been used recently for the systematic administration of drugs. The efficacy of local drug delivery to the lung depends on the amount and site of deposition within the lungs, as well as on post-deposition events. Therefore, quantifying regional deposition, dissolution, local clearance and absorption processes is important in assessing and optimising topical treatments as well as systemic delivery of drugs with limited lung bioavailability. Quantifying regional deposition in vivo via respiratory imaging remains challenging. Experimental, in vivo, assessment of deposition can be complimented by in vitro models often in combination with in silico methods, based in part on Computational Fluid Particle methods, and in part on hybrid 1D-3D methods. Similarly, it is difficult to directly quantify the clinical impact of kinetically competing processes of dissolution, clearance and permeation. Researches rely on a combination of ex vivo, in vitro and computational in silico methods. Yet, for in silico methods to be able to deliver their promise, they must be accepted into the drug development, regulation and approval cycle. Inhaled Medicines in the Age of in silico Population Studies responds to a need for well-designed protocols that will validate these emerging methods in order to generate the necessary consensus among the stakeholders involved. The book aims to show that the technological ingredients are in place, setting the stage for a future of inhaled drug development based in large part on in silico studies. Opportunities and challenges are addressed by a number of experts who tackle the drug delivery problem from different scientific angles. In this highly multidisciplinary field, where progress is occurring at the intersection of several fields of engineering and science, there is a clear need for a book that integrates knowledge and understanding and articulates a clear vision for the upcoming future.

Inhaled Medicines, Kassinos, Stavros