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Multi-Paradigm Modelling Approaches For Cyber-Physical Systems, Tekinerdogan, Bedir


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Цена: 19875.00р.
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Автор: Tekinerdogan, Bedir   (Бедир Текинердоган)
Название:  Multi-Paradigm Modelling Approaches For Cyber-Physical Systems
Перевод названия: Бедир Текинердоган: Подходы к мультипарадигмному моделированию киберфизических систем
ISBN: 9780128191057
Издательство: Elsevier Science
Классификация:


ISBN-10: 0128191058
Обложка/Формат: Paperback
Вес: 0.45 кг.
Дата издания: 01.11.2020
Язык: English
Размер: 235 x 191 x 17
Ссылка на Издательство: Link
Рейтинг:
Поставляется из: Европейский союз
Описание:

Truly complex, engineered systems, known as Cyber Physical Systems (CPS), are emerging to integrate physical, software, and network domains. To date, no unifying theory, systematic design methods, techniques or tools exist for such systems. Individual (mechanical, electrical, network or software) engineering disciplines offer only partial solutions. Multi-paradigm Modelling (MPM) proposes to model every aspect of these complex systems, at the most appropriate level(s) of abstraction and using the most appropriate modelling formalism(s). Modelling language engineering, including model transformation, and the study of their semantics, are used to realize MPM, which is seen as an effective answer to the challenges of designing Cyber Physical Systems.

Multi-Paradigm Modelling for Cyber-Physical Systems will explore modelling and analysis as crucial activities in the development of Cyber-Physical Systems, which are inherently cross-disciplinary in nature and require distinct modelling techniques related to different disciplines, as well as a common background knowledge bridge to enable communication between all specialties. The book will serve as a reference for anyone starting in the field of CPS who will need a solid foundation of modelling CPS and a comprehensive introduction to the distinct existing techniques, with clear explanations of their advantages and limitations. Although most of these techniques are already used as a matter of common practice in certain disciplines, the knowledge of their fundamentals and applications is typically unfamiliar to practitioners of another area. The net result is the tendency for CPS practitioners to use the technique that they are most comfortable with, disregarding the technique that would be the most adequate for the problem and modelling goal.

This book is aimed at both researchers and practitioners who are interested in various modelling paradigms across computer science and engineering. Researchers will gain novel insights into the basic theories and background, cutting-edge research topics, as well as the related challenges and research directions for model management and analytics. Practitioners will benefit from the presentation of key problems, solution approaches and tools which have been developed or are necessary for model management and analytics.




Multi-Scale Approaches in Drug Discovery

Автор: Speck-Planche, Alejandro
Название: Multi-Scale Approaches in Drug Discovery
ISBN: 0081011296 ISBN-13(EAN): 9780081011294
Издательство: Elsevier Science
Рейтинг:
Цена: 27791.00 р.
Наличие на складе: Поставка под заказ.

Описание:

Drug discovery is an expensive, time-consuming process and the modern drug discovery community is constantly challenged not only with discovering novel bioactive agents to combat resistance from known diseases and fight against new ones, but to do so in a way that is economically effective. Advances in both experimental and theoretical/computational methods envisage that the greatest challenges in drug discovery can be most successfully addressed by using a multi-scale approach, drawing on the specialties of a whole host of different disciplines. Multi-Scale Approaches to Drug Discovery furnishes chemists with the detail they need to identify drug leads with the highest potential before isolating and synthesizing them to produce effective drugs with greater swiftness than classical methods may allow. This significantly speeds up the search for more efficient therapeutic agents.

After an introduction to multi-scale approaches outlining the need for and benefits of their use, the book goes on to explore a range of useful techniques and research areas, and their potential applications to this process. Profiling drug binding by thermodynamics, machine learning for predicting enzyme sub-classes, and multitasking models for computer-aided design and virtual compound screening are discussed, before the book goes on to review Alkaloid Menispermaceae leads, natural chemotherapeutic agents and methods for speeding up the design and virtual screening of therapeutic peptides. Flavonoids as multi-target compounds are then explored, before the book concludes with a review of Quasi-SMILES as a novel tool.

Collecting together reviews and original research contributions written by leading experts in the field, Multi-Scale Approaches to Drug Discovery highlights cutting-edge approaches and practical examples of their implementation for those involved in the drug discovery process at many different levels. Using the combined knowledge of medicinal, computational, pharmaceutical and bio- chemists, it aims to support growth in the multi-scale approach to promote greater success in the development of new drugs.


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