Описание: While the safety assessment ("biocompatibility") of medical devices has been focused on issues of local tissue tolerance (irritation, sensitization, cytotoxicity) and selected quantal effects (genotoxicity and acute lethality) since first being regulated in the late 1950s, this has changed as devices assumed a much more important role in healthcare and became more complex in both composition and in their design and operation. Add to this that devices now frequently serve as delivery systems for drugs, and that drugs may be combined with devices to improve device performance, and the problems of ensuring patient safety with devices has become significantly more complex. A part of this, requirements for ensuring safety (once based on use of previously acceptable materials - largely polymers and metals) have come to requiring determining which chemical entities are potentially released from a device into patients (and how much is released).
Then an appropriate and relevant (yet also conservative) risk assessment must be performed for each identified chemical structure. The challenges inherent in meeting the current requirements are multifold, and this text seeks to identify, understand, and solve all of them. * Identify and verify the most appropriate available data.
* As in most cases such data is for a different route of exposure, transform it for use in assessing exposure by the route of interest. * As the duration (and rate) of exposure to moieties released from a device are most frequently different (longer) than what available data speaks to, transformation across tissue is required. * As innate and adaptive immune responses are a central part of device/patient interaction, assessing potential risks on this basis are required.
* Incorporating assessments for special populations such as neonates. * Use of (Q)SAR (Quantitative Structure Activity Relationships) modeling in assessments. * Performance and presentation of integrative assessments covering all potential biologic risks.
Appendices will contain summarized available biocompatibility data for commonly used device materials (polymers and metals) and safety assessments on the frequently seen moieties in extractions from devices.
Автор: E. Garaci; Allan L. Goldstein Название: Combination Therapies ISBN: 1461364728 ISBN-13(EAN): 9781461364726 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: These molecules, termed biological response modifiers (BRMs) , have been sequenced, synthesized and produced in large enough quantities to test in animals and humans resulting in the development of new approaches to the treatment of human disease, in particular, cancers and infectious diseases.
Описание: Abstract: For odd degrees of freedom the characteristic function of a Student-t random variable is expressible in closed form. The characteristic function of an arbitrary linear combination of independent t-variables is then derived and the distribution function is obtained, itself expressible as a weighted sum of Student-t distribution functions. An easy method of obtaining the weights is demonstrated. If U1, U1, ..., Un are independent random variables and Xi = d + Ui, i=1,2, ..., n are observable random variables, we investigate the choice of a1, a2, ..., an to maximize the power of tests of the form a1X1 + a2X2 + ... + anXn for testing Ho: d = 0 against H1: d > 0. Some general results and examples are given. Of particular interest is the case when Xi is a t-random variable. One application is in a two-stage sampling procedure to solve the Behrens-Fisher problem. The test statistic has the distribution of a weighted sum of t-random variables. It is shown how to choose the weights for maximum power. Dissertation Discovery Company and University of Florida are dedicated to making scholarly works more discoverable and accessible throughout the world. This dissertation, "On the Distribution of a Linear Combination of T-distributed Variables" by Glenn Alan Walker, was obtained from University of Florida and is being sold with permission from the author. A digital copy of this work may also be found in the university's institutional repository, IR@UF. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation.
Автор: Harrison Название: Combination Treatment in Autoimmune Disseases ISBN: 3540430369 ISBN-13(EAN): 9783540430360 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book consists of contributions from the most prominent experts in this field. In the first section the general principles of combination treatment are discussed, from rationale and methodology to benefits of risks in daily practice. The second section concerns specific diseases. It is striking that although there is so much experience with combining DMARDS in RA, for several other autoimmune diseases combination therapy has not yet been developed. Denton and Black, on the other hand, are able to add a refreshing new meaning to the term "combination therapy" in systemic sclerosis by pointing out the aetiologies beyond those caused by immunopathology, and dealing with combinations of therapy to address issues beyond immunotherapy. The last section is devoted to the future, and the editors hope to come back in 2010 with an issue which will look back and determine whether the predictions of Brooks, Moore, Huizinga and Breedveld have come true.
Автор: Schuemann MS Nancy Loyan Название: The Right Combination ISBN: 098619008X ISBN-13(EAN): 9780986190087 Издательство: Неизвестно Цена: 2233.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Maciej Banach Название: Combination Therapy In Dyslipidemia ISBN: 3319204327 ISBN-13(EAN): 9783319204321 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Comprising contributions from leading lipidologists from around the world, this book presents the latest and most comprehensive knowledge on the different options for combination therapy of dyslipidemia and includes discussion of future therapies that are currently in late stages of clinical evaluation. Dyslipidemia is a leading cause of cardiovascular morbidity and mortality and most patients with this condition fail to achieve adequate control of their serum lipid levels with monotherapy. However, recent US and European guideline recommendations, based on randomized, controlled trials, fail to discuss combination therapy options for patients with dyslipidemia.Statins remain the mainstay of drug therapy for hyperlipidemia and chapters in this book specifically examine the role of add-on therapy with different agents modulating the different lipid fractions in the blood, e.g. bile acid sequestrants, fibric acid derivatives (fibrates), omega-3 fatty acids (fish oils), inhibitors of Niemann-Pick C1 like 1 (NPC1L1) protein, cholesteryl ester transfer protein (CETP), apolipoprotein B-100 and microsomal triglyceride transfer protein (MTP) and the emerging proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors. There is additional discussion of the role of non-drug therapy options such as nutraceuticals, functional foods and lipoprotein apheresis. The book also discusses the combination of antihypertensive drugs with lipid-lowering drugs in the management of cardiovascular risk in patents with dyslipidemia.
Learn self acupuncture combined with relaxation, herbs, diet and hydrotherapy healing practices for the 70 most frequent diseases.
Reading the book, you will be able to understand and apply simple but effective self acupuncture.
Moreover prayer, meditation, self-hypnosis, muscle test for selecting food-substances, fasting therapy, fruit therapy, raw food diet, Mediterranean diet, sprouts, home spa bath, home steam bath, use of herbs (preparation of infusions, decoctions, ointments, oils, tinctures, compresses, poultices), "panacea herbs" and grandma's remedies are some of the healing treatments for the 70 most frequent diseases, which are extensively analyzed in the book.
For instance headache is a common ailment people all over the world suffer from. The book provides detailed alternative treatments for it, for example you can insert a needle at the point between the eyebrows, called Extra 1 or third eye. Or you can massage gently this point with slow circular movements, do fast eye movements in all directions and then drink some soothing tea as chamomile, common lime, St John's wort, melissa, oregano or common thyme depending on the muscle test for selecting food-substances.
If you are afraid of needles, stick adhesive magnets on acupoints using the instructions in the book.
If you think you are unable to find the points, don't worry because the book is accompanied by a DVD with detailed demonstration of how to find the acupuncture points. There is nothing easier than inserting a needle exactly where it hurts.
You can also use the grandma's remedies for headache which are mentioned in the book:
a. chew one rue (ruta graveolens) leaf. b. sniff 5 drops of marjoram (origanum majorana) leaves juice. c. patients suffering from migraine must avoid chocolates, milk and combining wine with cheese. d. tie the suffering area with compresses or bandanna impregnated with vinegar or lemon. e. place a raw potato or onion slice on the suffering area, refresh it every hour. f. for headache due to menopause drink infusion of 10g saffron crocus (crocus sativus) in 1 L water. g. massage the suffering area using 5 drops of essential oil lavandula officinalis or mentha piperata or origanum majorana. h. have a cold footbath, especially if you have warm feet. i. massage the lobule of the ear ipsilateral to the pain or the dominant ear for 15 minutes. j. put herbs that you like in your pillow. The Knowledge acquired from this book is directly applicable anytime, anywhere and by anyone, even without a needle. Help yourself, when you need it, with simple, inexpensive healing methods without side effects. For the first time on a global level, it is stated in the book that the Primary Meridians (the main energy routes in the human body) consist of ten vibrating fibers, and the space between them fluctuates in proportion to the yin and yang energy.
For the first time on a global level, the waveform of the energy which is absorbed or emitted from the head of the needle at stimulation or dispersion during acupuncture is analyzed in the book.
For the first time, the Hellenic herbal needles are mentioned and details are provided for their use; I strongly suggest that they should be exported abroad. For the first time a great number of herbs are classified according to the Empedoclean-Hippocratic doctrine.
You have been created in image and likeness of God, which means you have endless potential of spiritual evolution and self-healing.
Knowledge of self-treatment is the way to find happiness, the conquest of happiness is waiting for you...
Автор: Lamche, Tag Название: Coaching combination play - from build up to finish ISBN: 191049111X ISBN-13(EAN): 9781910491119 Издательство: Неизвестно Рейтинг: Цена: 7348.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Tag Lamche (UEFA `A` Coaching Licence Part 1) is a professional academy coach and a specialist in vision and awareness. In this book Tag shows you how to play "From Build Up to Finish," providing numerous practical examples of combination play from the keeper, through defence, midfield and attack to create goal scoring opportunities.
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