Immunotherapeutic Strategies For The Treatment Of Glioma, Lim, Michael
Автор: Michael E. Sughrue Название: The Glioma Book ISBN: 1626234442 ISBN-13(EAN): 9781626234444 Издательство: Thieme Verlagsgruppe Рейтинг: Цена: 26425.00 р. Наличие на складе: Поставка под заказ.
Описание:
A unique resource on glioma leverages advances and firsthand insights to enact meaningful change
Glioblastoma (GBM) or glioma is an extremely aggressive and malignant brain tumor, with cell infiltration, rapid invasion, and a high frequency of relapse. The Glioma Book by neurosurgeon Michael Sughrue is a highly personal book -- a culmination of two years of writing and more than 1,000 surgeries. It presents a unique viewpoint with the potential to transform the traditional paradigm that too often informs treatment of this universally fatal brain tumor. The book reinterprets the role of the cerebrum and sub-cortex, leverages scientific advances to improve cytoreduction and reduce neurological deficits, and challenges the myth of the "inoperable" glioma.
This is the first step-by-step technical guide focused on aggressively resecting different types of gliomas. The book is logically organized, starting with a foundation of fundamental knowledge, then progressing to practical applications. Chapters focus on the skills necessary to perform glioma surgery, specific techniques, and systematic approaches to gliomas in different brain regions.
Numerous case examples illuminate concepts introduced earlier in the book and explain how to perform these procedures
About 30 high quality videos posted online provide insightful procedural guidance
The role of connectomic imaging in visualizing the cerebrum, and other innovative techniques including awake brain mapping and diffusion tensor tractography
Neurosurgeons who embrace the concepts in this book will realize they can change the glioma treatment paradigm. Continually improving techniques and viewing a glioma diagnosis as a battle for a patient's life, rather than an exercise in inevitable failure can impart progress in treating this devastating disease.
This book includes complimentary access to a digital copy on https: //medone.thieme.com.
Автор: Martin Matthew Название: Glioma: Recent Advances in Therapeutic Procedures ISBN: 1632412306 ISBN-13(EAN): 9781632412300 Издательство: Неизвестно Цена: 26843.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Glioma is a type of tumor which occurs in the brain and spine. This book presents an elaborative compilation of latest information and emerging possibilities for designing novel therapies for Glioma by an array of veterans ranging from cell biologists to
Автор: A.B.M.F. Karim; Edward R. Jr. Laws Название: Glioma ISBN: 3540522867 ISBN-13(EAN): 9783540522867 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This study analyzes the problems and pitfalls encountered in the quest for an optimal treatment of brain tumours. Principles and innovations are reviewed by a number of researchers, and guidelines are presented which aim to improve the quality of life or to possibly cure patients with glioma.
Описание: This book discusses the immunotherapeutic potential of Interleukin 12 in the context of clinical oncology, as well as antitumor effects confirmed in preclinical studies and clinical trials in cancer immunotherapy. Due to its ability to activate both innate (NK cells) and adaptive (cytotoxic T lymphocytes) immunities, Interleukin 12 (IL-12) has been regarded as a promising candidate for tumor immunotherapy. However, despite the encouraging results in animal models, only very modest antitumor effects have been confirmed in early clinical trials. Recently, several clinical studies have been initiated in which IL-12 was applied as an adjuvant in cancer vaccines, in gene therapy including locoregional injections of IL-12 plasmid, and in the form of tumor-targeting immunocytokines (IL-12 fused to monoclonal antibodies).
Автор: Martin Matthew Название: Clinical Theory and Practical Aspects of Glioma ISBN: 1632410893 ISBN-13(EAN): 9781632410894 Издательство: Неизвестно Цена: 22981.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The title of this book is in itself suggestive about the content it covers. It discusses glioma progression, immunology, glioma model and culture systems, oxidative stress in glioma and experimental approach to glioma therapeutics. We hope that this book
Автор: Theobald Название: Current Immunotherapeutic Strategies in Cancer ISBN: 3030237648 ISBN-13(EAN): 9783030237646 Издательство: Springer Рейтинг: Цена: 11878.00 р. Наличие на складе: Поставка под заказ.
Описание: This book offers a comprehensive review of recent advances in cancer immunotherapy, and explores the value and limitations of the most effective current therapeutic strategies and emerging treatment modalities.
Описание: Cancer care is undergoing a radical transformation as novel technologies are directed toward new treatments and personalized medicine. The most dramatic advances in the treatment of cancer have come from therapeutics that augment the immune response to tumors. The immune checkpoint inhibitors are the best-known and most highly advanced examples of Immune Therapeutics targeting tumor cells and include approved antibody drugs directed at the cell surface proteins CTLA4 and PD-1. These are now considered foundational treatments for several solid tumor indications, and that list of indications is growing quickly. More broadly, antibodies have become workhorse molecules across the entire immunotherapy landscape. Antibodies to novel targets modulate the activity of diverse immune cell regulatory proteins. Engineered antibodies can induce tumor cell death or expose tumor cells to poisonous toxins (ADCC and ADC, respectively). Bi-specific antibodies can engage multiple tumor targets simultaneously, or can redirect lymphocytes to attack tumor cells. The antigen-binding domains within antibodies can be spliced onto cell stimulatory domains and transduced into T cells or NK cells, creating remarkable tumor-specific cellular therapeutics (CAR-T, CAR-NK). Beyond antibody-based therapies there are highly diverse and differentiated technology tool kits being applied to immunotherapy. Small molecule drugs are being developed to attack the tumor microenvironment, novel tumor vaccine approaches are showing great promise, patient lymphocytes are being isolated, expanded and reintroduced to patients, gene-editing techniques are becoming widely deployed, and a vast number of new tumor targets, and mutated tumor proteins (neoantigens), are being discovered. The past decade has seen unprecedented success in the treatment of diverse cancers. The authors of this volume have been asked to not only review progress to date, but importantly, to look ahead, and anticipate the evolution of cancer treatment across diverse Immune Therapeutic approaches. Our hypothesis is that the advances we are seeing across the immunotherapy landscape will further evolve and synergize, leading us finally to outright cures for many cancers.
Автор: Benjamin Bonavida Название: Resistance to Immunotherapeutic Antibodies in Cancer ISBN: 1489987320 ISBN-13(EAN): 9781489987327 Издательство: Springer Рейтинг: Цена: 19589.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book examines antibody-mediated anti-cancer therapy, covering the use of mAbs against various cancers, developments in the molecular, biochemical and genetic mechanisms of resistance by various mAbs and novel mAbs to overcome drug and radition resistance.
Автор: Benjamin Bonavida Название: Resistance to Immunotherapeutic Antibodies in Cancer ISBN: 1461476534 ISBN-13(EAN): 9781461476535 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book examines antibody-mediated anti-cancer therapy, covering the use of mAbs against various cancers, developments in the molecular, biochemical and genetic mechanisms of resistance by various mAbs and novel mAbs to overcome drug and radition resistance.
Автор: Oberg Название: Management of Adult Glioma in Nursing Practice ISBN: 3319767461 ISBN-13(EAN): 9783319767468 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Поставка под заказ.
Описание: This contributed book focuses on the nursing care and considerations for the most common type of malignant brain tumours - gliomas, out of the 150 different types of brain tumours .
Описание: This two-volume set LNCS 11383 and 11384 constitutes revised selected papers from the 4th International MICCAI Brainlesion Workshop, BrainLes 2018, as well as the International Multimodal Brain Tumor Segmentation, BraTS, Ischemic Stroke Lesion Segmentation, ISLES, MR Brain Image Segmentation, MRBrainS18, Computational Precision Medicine, CPM, and Stroke Workshop on Imaging and Treatment Challenges, SWITCH, which were held jointly at the Medical Image Computing for Computer Assisted Intervention Conference, MICCAI, in Granada, Spain, in September 2018. The 92 papers presented in this volume were carefully reviewed and selected from 95 submissions. They were organized in topical sections named: brain lesion image analysis; brain tumor image segmentation; ischemic stroke lesion image segmentation; grand challenge on MR brain segmentation; computational precision medicine; stroke workshop on imaging and treatment challenges.
Автор: M. Westphal; J.-C. Tonn; Z. Ram Название: Local Therapies for Glioma ISBN: 3709172284 ISBN-13(EAN): 9783709172285 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Image guided resection procedures, fluorescence guided surgery, developments in interstitial radiosurgery are addressed, just as intracavitary chemotherapy and all current concepts and studies of interstitial targeted therapy.
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