This unique advanced textbook provides a clear and comprehensive overview of gene delivery, gene therapy and genetic pharmacology, with descriptions of the main gene transfer vectors and a set of selected therapeutic applications, along with safety considerations. The second edition features new groundbreaking material on genome editing using the recently discovered CRISPR/Cas9 system and on cancer immunotherapy by CAR-T cells. It also presents the historical milestone of gene therapy application in the field of severe combined immunodeficiency, and other fields of gene therapy and molecular medicine.
The use of gene transfer is exponentially growing in the scientific and medical communities for day-to-day cell biology experiments and swift development of gene therapy, which is already revolutionizing medicine. In this advanced textbook, more than 30 leading scientists come together to explore these topics.
This educational introduction provides the background material needed to further explore the subject as well as relevant research literature. It is an invaluable resource to Master, PhD or MD students, post-doctoral scientists or medical doctors, as well as any scientist wishing to deliver a gene or synthetic nucleotide or develop a gene therapy strategy. The second edition's simple and synthetic content will be of value to any reader interested in the biological and medical revolution derived from the elucidation of the human genome.
Автор: Patil Popat M Название: Discoveries In Pharmacological Sciences ISBN: 9814355070 ISBN-13(EAN): 9789814355070 Издательство: World Scientific Publishing Рейтинг: Цена: 27720.00 р. 39600.00-30% Наличие на складе: Есть (1 шт.) Описание: Throughout history, the perpetuation of species, the need for survival, and human curiosity, intelligence and skills provided the basis for the development of drug science. This title contains the history of herbal medicine as it emerged about 5,000 years ago.
Автор: Pablo Avanzas; Juan Carlos Kaski Название: Pharmacological Treatment of Chronic Stable Angina Pectoris ISBN: 3319173316 ISBN-13(EAN): 9783319173313 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book is intended for general cardiologists and other physicians involved in the care of patients with chronic stable angina (CSA). The management of these patients encompasses lifestyle modification, control of coronary artery disease risk factors, evidence-based pharmacological therapy and patient education.
Автор: Avanzas, Pablo, Clemmensen, Peter Название: Pharmacological Treatment of Acute Coronary Syndromes ISBN: 1447154231 ISBN-13(EAN): 9781447154235 Издательство: Springer Рейтинг: Цена: 6288.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book presents key knowledge that a cardiovascular professional needs to know on a day-to-day basis, written in a quick-access, no-nonsense format.
Описание: Few pathologie phenomena, as shock, can originate from so many causes and involve so many complex physiologie mechanisms: The complexity of the phenomenon, thus, has resulted in extensive study and raised many uncertainties.
Описание: Although there are over 400,000 people each year in the United States alone who suffer from traumatic injury to the central nervous system (CNS), no phar- macological treatment is currently available.
Автор: A. Claudio Cuello Название: Pharmacological Mechanisms in Alzheimer`s Therapeutics ISBN: 1441924469 ISBN-13(EAN): 9781441924469 Издательство: Springer Рейтинг: Цена: 26552.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The need for effective therapy to treat Alzheimer`s disease is greater than ever, but there is still no drug therapy that can stop or reverse the progression of the disease.
Описание: Jacket Description/Back:
Medicinal Chemistry and Pharmacological Potential of Fullerenes and Carbon Nanotubes features important insights into the applications of fullerenes and carbon nanotubes. It discusses the fullerene and nanotubes derivatives which are effective against viruses, cells, and bacteria and those which are able to interact and inhibit certain enzymes. Also covered in this book are the formation of complex structures between biologically active molecules and carbon materials. Furthermore, the application of fullerenes in certain medical therapies is explored, including the very recent discovery of new bio-compatible media which could be used as carriers in the delivery of fullerenes in vivo. An additional topic of this text is the formation of hybrids between nanotubes and biological molecules and their use as chemical sensors.
Medicinal Chemistry and Pharmacological Potential of Fullerenes and Carbon Nanotubes will be a useful tool of reference for researchers, postgraduates and advanced undergraduates in the Chemical, Biomedical, and Materials sciences.
Publisher Marketing:
Fullerenes and nanotubes are two classes of carbon structures or allotropes, which were discovered about 17 years ago. Since that time, many chemical derivatives have been synthesized using fullerenes and nanotubes as building blocks.
Particularly promising was the theory that the chemical properties of fullerenes, and certain derivatives, made them likely candidates for anticancer drugs, inhibitors of viruses such as HIV, or even as anti-bacterials. Their cyctotoxicity can also be controlled by specific circumstances.
In addition, the funtionalization of nanotubes has not only produced relatively simple derivatives, but also complex hybrids with biological macromolecules, which show unique supramolecular architecture and which are promising in many medical applications.
The application of fullerenes and nanotubes in medicine is at the frontier of our knowledge, thus the work in this field represents the basis for future novel developments.
Автор: Thangaraj Parimelazhagan Название: Pharmacological Assays of Plant-Based Natural Products ISBN: 3319268104 ISBN-13(EAN): 9783319268101 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: After a detailed in vitro investigation including nutritional and anti-nutritional analyses, medicinal properties were tested with various in vivo models for anti-inflammatory, analgesic, anti-pyretic, anticancer and anti-diabetic properties, as well as wound healing, neurodegenerative diseases, etc.
Описание: This book focuses on dopamine-mediated regulation of gene expression within the striatum and associated regions of the central nervous system. It is an excellent review of experimental data on interactions between neuronal systems at systemic, cellular, and molecular levels. Each of the chapters, written by the world's leading scientists, provides an understanding of anatomy, neurochemistry, and cellular and molecular effects. Such an understanding sheds light on the pathophysiology of central disorders involving the basal ganglia and leads to new approaches for the treatment of diseases such as Parkinson's disease and schizophrenia, and also addictions to psychostimulants such as cocaine and amphetamines.
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