Primer of population genetics and genomics, Hartl, Daniel L. (higgins Professor Of Biology, Higgins Professor Of Biology, Department Of Immunology And Infectious Diseases, Harvard University, Us
This unique advanced textbook provides a clear and comprehensive overview of gene delivery, gene therapy and genetic pharmacology, with descriptions of the main gene transfer vectors and a set of selected therapeutic applications, along with safety considerations. The second edition features new groundbreaking material on genome editing using the recently discovered CRISPR/Cas9 system and on cancer immunotherapy by CAR-T cells. It also presents the historical milestone of gene therapy application in the field of severe combined immunodeficiency, and other fields of gene therapy and molecular medicine.
The use of gene transfer is exponentially growing in the scientific and medical communities for day-to-day cell biology experiments and swift development of gene therapy, which is already revolutionizing medicine. In this advanced textbook, more than 30 leading scientists come together to explore these topics.
This educational introduction provides the background material needed to further explore the subject as well as relevant research literature. It is an invaluable resource to Master, PhD or MD students, post-doctoral scientists or medical doctors, as well as any scientist wishing to deliver a gene or synthetic nucleotide or develop a gene therapy strategy. The second edition's simple and synthetic content will be of value to any reader interested in the biological and medical revolution derived from the elucidation of the human genome.
Автор: T. Brown Название: Genomes 4 ISBN: 0815345089 ISBN-13(EAN): 9780815345084 Издательство: Taylor&Francis Рейтинг: Цена: 9645.00 р. Наличие на складе: Поставка под заказ.
Описание:
Genomes 4 has been completely revised and updated. It is a thoroughly modern textbook about genomes and how they are investigated. As with Genomes 3, techniques come first, then genome anatomies, followed by genome function, and finally genome evolution. The genomes of all types of organism are covered: viruses, bacteria, fungi, plants, and animals including humans and other hominids.
Genome sequencing and assembly methods have been thoroughly revised including a survey of four genome projects: human, Neanderthal, giant panda, and barley. Coverage of genome annotation emphasizes genome-wide RNA mapping, with CRISPR-Cas 9 and GWAS methods of determining gene function covered. The knowledge gained from these techniques forms the basis of the three chapters that describe the three main types of genomes: eukaryotic, prokaryotic (including eukaryotic organelles), and viral (including mobile genetic elements). Coverage of genome expression and replication is truly genomic, concentrating on the genome-wide implications of DNA packaging, epigenome modifications, DNA-binding proteins, non-coding RNAs, regulatory genome sequences, and protein-protein interactions. Also included are applications of transcriptome analysis, metabolomics, and systems biology. The final chapter is on genome evolution, focusing on the evolution of the epigenome, using genomics to study human evolution, and using population genomics to advance plant breeding. Established methods of molecular biology are included if they are still relevant today and there is always an explanation as to why the method is still important.
Each chapter has a set of short-answer questions, in-depth problems, and annotated further reading. There is also an extensive glossary. Genomes 4 is the ideal text for upper level courses focused on genomes and genomics.
Автор: Sall, T. Bengt O. Bengtsson Название: Understanding Population Genetics ISBN: 1119124034 ISBN-13(EAN): 9781119124030 Издательство: Wiley Рейтинг: Цена: 8229.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: An inspiring introduction to a vital scientific field. The reader is taken through ten mathematical derivations that lead to important results, explaining in a hands-on manner the key concepts and methods of theoretical population genetics. The derivations are carefully worked out and easy to follow.
Автор: Xia Название: A Mathematical Primer of Molecular Phylogenetics ISBN: 1771887559 ISBN-13(EAN): 9781771887557 Издательство: Taylor&Francis Рейтинг: Цена: 17762.00 р. Наличие на складе: Поставка под заказ.
Описание: The volume provides sufficient mathematical background for young mathematicians and computational scientists, as well as mathematically inclined biology students, to make a smooth entry into the expanding field of molecular phylogenetics.
Автор: Michael Hehenberger, Zhi Xia Название: Our Animal Connection: What Sapiens Can Learn From Other Species ISBN: 9814800481 ISBN-13(EAN): 9789814800488 Издательство: Taylor&Francis Рейтинг: Цена: 9492.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The book covers the many ways humans benefit from interactions with other living species. By studying animals of all kinds and sizes, from microbial organisms to elephants and whales, we can learn about their adaptations to extreme conditions on planet Earth, about the evolutionary development of specialized capabilities, and about their ways to defend themselves against predators and diseases. We discuss the strengths and weaknesses of Homo Sapiens, and how the study of animals can make us stronger and healthier. To increase our knowledge of genetics, molecular and cell biology, physiology and medicine, we need to study model organisms. To cure human disease, we can learn from animals how they have evolved ways to protect themselves. To improve our human performance, we can study the animal kingdom’s top performers and possibly learn from their successes. Finally, we review genetic engineering techniques that can translate our existing and future animal connections into benefits for human health and performance.
Описание: Bringing together leading experts in the field of network data analysis, this text introduces biological concepts and biotechnologies producing the data, graph and network theory, cluster analysis and machine learning. Using real-world biological and medical examples, applications of these theories are discussed and creative thinking is encouraged in the analysis of such complex network data sets.
Автор: Wilkins Ralph G. Название: Animal Genetics for Chemists ISBN: 178262760X ISBN-13(EAN): 9781782627609 Издательство: Royal Society of Chemistry Рейтинг: Цена: 7390.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Setting out to cover the fundamentals of the subject, this book features humans, other mammals and occasionally other animals to illustrate principles.
Автор: Daniel L. Hartl; Andrew G. Clark Название: Principles of Population Genetics ISBN: 0878933085 ISBN-13(EAN): 9780878933082 Издательство: Springer Рейтинг: Цена: 15689.00 р. Наличие на складе: Поставка под заказ.
Описание: David Lindsay was a writer of fantasy fiction who died in 1945. Interest in Lindsay has been growing steadily, and in this book, Bernard Sellin has written a comprehensive survey of Lindsay`s life and work, analysing the thematic patterns of Lindsay`s settings, plots and characters. It will be read with profit by all those who are interested both in Lindsay and in the genre of fantasy literature.
Автор: Hartl, D.L. Название: Essential Genetics: a Genomics Perspective ISBN: 1449686885 ISBN-13(EAN): 9781449686888 Издательство: Jones & Bartlett Рейтинг: Цена: 11614.00 р. Наличие на складе: Поставка под заказ.
Описание: Every new copy includes access to the student companion website Updated throughout to reflect the latest discoveries in this fast-paced field, Essential Genetics: A Genomics Perspective, Sixth Edition, provides an accessible, student-friendly introduction to modern genetics. Designed for the shorter, less comprehensive course, the Sixth Edition presents carefully chosen topics that provide a solid foundation to the basic understanding of gene mutation, expression, and regulation. It goes on to discuss the development and progression of genetics as a field of study within a societal and historical context. The Sixth Edition includes new learning objectives within each chapter which helps students identify what they should know as a result of their studying and highlights the skills they should acquire through various practice problems. What's new in the Sixth Edition? Chapter 1 includes a new section on the origin of life Chapter 2 includes a revised discussion of the complementation test and how it is used to determine whether two mutations have defects in the same gene Chapter 3 incorporates new data showing that the folding of interphase chromatin into chromosome territories has the form of a fractal globule. It also includes a new section on progenitor cells and embryonic stem cells Chapter 4 includes a new section discussing how copy-number variation in human amylase evolved in response to increased dietary starch as well as the latest on hotspots of recombination Chapter 5 is updated with the latest information on hazards of polycarbonate food containers. It also includes a new section on the genetics of schizophrenia and autism spectrum disorder Chapter 6 includes a revised section on restriction mapping and also discusses the newest massively parallel DNA sequencing technologies that can yield the equivalent of 200 human genomes' worth of DNA sequence in a single sequencing run Chapter 7 has been updated with a shortened and streamlined discussion of recombination in bacteriophage Chapter 8 includes new discoveries concerning the mechanisms of intrinsic transcriptional termination as well as rho-dependent termination Chapter 9 is updated with a new section on stochastic effects on gene expression and an expanded discussion of the lactose operon. There is also a revised discussion of galactose gene regulation in yeast, as well as new sections on lon noncoding RNAs Chapter 10 includes new sections on ancient DNA sequences of the Neandertal and Denisovan genomes Chapter 11 examines master control genes in development Chapter 12 includes a new section on the repair of double-stranded breaks in DNA by nonhomologous end joining or template-directed gap repair Chapter 13 has been extensively revised with the latest data on cancer. Chapter 14 includes a new section on the detection of natural selection, as well as a new section on conservation genetics Key Features of Essential Genetics, Sixth Edition: New Learning Objectives within each chapter help students to: Identify what they should know or be able to do as a result of their study Focus on the knowledge they should have acquired from studying the chapter Guide them to identify key concepts and use them at a variety of learning levels including comprehension, application, analysis, and synthesis Highlight the skill they should acquire through practice of various problem types Each chapter includes several different types and levels of problems, including: concept, synthesis, and discussion questions, problem solving questions, and application and analysis problems. The companion Website, GeNETics on the Web, includes numerous study tools and learning resources such as animated flashcards, crosswords, and practice quizzes An electronic Student Study Guide and Solutions Manual is available, containing chapter summaries, key terms, and extra study questions, as well as worked
Автор: Cutter Asher D Название: Primer of Molecular Population Genetics ISBN: 0198838956 ISBN-13(EAN): 9780198838951 Издательство: Oxford Academ Рейтинг: Цена: 8237.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Provides a concise, accessible introduction to the principal ideas, methods, and caveats for understanding evolution at the molecular level.
Автор: Cutter, Asher D. (professor, Professor, Department Of Ecology & Evolutionary Biology, University Of Toronto, Canada) Название: Primer of molecular population genetics ISBN: 0198838948 ISBN-13(EAN): 9780198838944 Издательство: Oxford Academ Рейтинг: Цена: 15840.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Provides a concise, accessible introduction to the principle ideas, methods, and caveats for understanding evolution at the molecular level.
ООО "Логосфера " Тел:+7(495) 980-12-10 www.logobook.ru
