Each week, people read about new and exciting cancer drugs. Some of these drugs are truly transformative, offering major improvements in how long patients live or how they feel--but what is often missing from the popular narrative is that, far too often, these new drugs have marginal or minimal benefits. Some are even harmful. In Malignant, hematologist-oncologist Dr. Vinayak K. Prasad writes about the many sobering examples of how patients are too often failed by cancer policy and by how oncology is practiced. Throughout this work, Prasad illuminates deceptive practices which
- promote novel cancer therapies long before credible data are available to support such treatment - exaggerate the potential benefits of new therapies, many of which cost thousands and in some cases hundreds of thousands of dollars
Prasad then critiques the financial conflicts of interest that pervade the oncology field, the pharmaceutical industry, and the US Food and Drug administration.
This is a book about how the actions of human beings--our policies, our standards of evidence, and our drug regulation--incentivize the pursuit of marginal or unproven therapies at lofty and unsustainable prices. Prasad takes us through how cancer trials are conducted, how drugs come to market, and how pricing decisions are made, asking how we can ensure that more cancer drugs deliver both greater benefit and a lower price. Ultimately, Prasad says,
- more cancer clinical trials should measure outcomes that actually matter to people with cancer; - patients on those trials should look more like actual global citizens; - we need drug regulators to raise, not perpetually lower, the bar for approval; and - we need unbiased patient advocates and experts.
This well-written, opinionated, and engaging book explains what we can do differently to make serious and sustained progress against cancer--and how we can avoid repeating the policy and practice mistakes of the past.
Автор: Chaturvedi Название: Manual Of Rheumatology 5Ed (Hb 2018) ISBN: 9387085031 ISBN-13(EAN): 9789387085039 Издательство: CBS India Рейтинг: Цена: 4402.00 р. Наличие на складе: Нет в наличии.
Автор: Praveen Khilnani, Santosh T Soans, Vinayak Patki Название: IAP Textbook of Pediatric ICU Protocols ISBN: 9352709691 ISBN-13(EAN): 9789352709694 Издательство: JayPee Brothers India Рейтинг: Цена: 7022.00 р. Наличие на складе: Нет в наличии.
Описание: Aiming to provide adequate preparation in algebra to prospective teachers and researchers in mathematics, this book delves into the intricacies of Algebra. Starting with the groups of symmetries of plane configurations, then moving onto study groups and their homomorphisms, before diving into the complexities of Sylow`s theorems and Abelian groups
Автор: Hunaid A Vohra, Vinayak Bapat, Christopher P Young Название: Minimally Invasive Aortic Valve Surgery ISBN: 1634854993 ISBN-13(EAN): 9781634854993 Издательство: Nova Science Рейтинг: Цена: 24234.00 р. Наличие на складе: Невозможна поставка.
Описание: Minimally invasive aortic valve surgery is a relatively new field which cardiac surgeons are increasingly embracing, and patients and cardiologists are demanding this with more enthusiasm. This is a current subject of great interest with contemporary results already present and more are awaited. This book describes the process through the set-up of a minimally invasive aortic valve surgery program, pertinent investigations, patient selection, different approaches (including endoscopic and robotic), cardio-pulmonary bypass, re-operations and their application with rapid deployment and aortic vascular surgery. This book is intended for all training cardiac surgeons and cardiologists, consultant cardiac surgeons and cardiologists, anaesthetists, intensive care specialists and perfusionists. This is the first book authored exclusively on this subject. The three editors are leading authorities on this subject in the UK and are mentors for many surgical programs. Every chapter is authored by experts in this particular aspect of minimally invasive aortic valve surgery. These surgeons are mainly from the United States, Australia and Europe.
Описание: Timeless secrets extracted from priceless scripturesFor Success, Happiness, Peace, Prosperity and Liberation. Authentic, Spiritual and Scientific. Nothing religious about it. Expect to receive divine love, God`s grace and prepare yourself for a total and positive life transformation.
Автор: Gole, Vinayak Shiralkar, Shreekant Название: Empower decision makers with sap analytics cloud ISBN: 1484260961 ISBN-13(EAN): 9781484260968 Издательство: Springer Рейтинг: Цена: 8384.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Chapter 1: Current Trends in Analytics and SAP's Road Map
Chapter Goal: To understand the latest trends in analytics and how SAP is adapting to these trends. To understand SAP's digital core and how analytics forms a pillar of the methodology.
Chapter 2: Business Scenario for Analytics Landscape Transformation Chapter Goal: To understand a real-world scenario of an enterprise which is planning to upgrade its traditional business intelligence to a modern analytics landscape.
Sub topics:
Customer introduction
Customer's current landscape and pain points
Customer's expectation from analytics landscape
Expected landscape
Chapter 3: SAC for enabling "Single Version of Truth"Chapter Goal: Understand how SAP Analytics Cloud enables a single platform for multiple data sources to come together for analysis.
Sub topics:
Analysis of customer requirement
Alignment to specific SAP Analytics Cloud capability
Step by step process to implement the capability
Customer benefits and future direction
Chapter 4: Leverage SAC to create "All-in-one" Analytics PlatformChapter Goal: SAC enables analytics for multiple business roles in an organization with options for 360 degree dashboards to self service data analysis to planning. This chapter explores these capabilities in detail.
Sub topics:
Analysis of customer requirement
Alignment to specific SAP Analytics Cloud capability
Step by step process to implement the capability
Customer benefits and future direction
Chapter 5: Exploit "Augmented Analytics" capability of SACChapter Goal: SAC enables self-service with augmented analytics like search to insight and multiple smart features. This chapter explores each of these concepts in detail along with benefits of each feature.
Sub topics:
Analysis of customer requirement
Alignment to specific SAP Analytics Cloud capability
Step by step process to implement the capability
Customer benefits and future direction
Chapter 6: Develop SAC for "Anytime Available" PlatformChapter Goal: One of the advantages of cloud application is the accessibility in addition to the freedom from maintaining costly infrastructure. This chapter explores how SAC is available across time zones and across devices.
Sub topics:
Analysis of customer requirement
Alignment to specific SAP Analytics Cloud capability
Step by step process to implement the capability
Customer benefits and future direction
Chapter 7: Capitalize on "Predictive Analytics" capability through SACChapter Goal: SAC includes built in capabilities to create predictive models and incorporate predictive analytics in data analysis and dashboards. This chapter explores this capability in detail.
Sub topics:
Analysis of customer requirement
Alignment to specific SAP Analytics Cloud capability
Step by step process to implement the capability
Customer benefits and future direction
Chapter 8: Craft Special Business Requirements on SAC via Custom Application DesignChapter Goal: One of the recently added capability is to build custom applications using a scripting language very similar to JavaScript. This enables developers to create custom apps and make them available for the business. This capability is the focus of this chapter
Sub topics:
Analysis of customer requirement
Alignment to specific SAP Analytics Cloud capability
Step by step process to implement the capability
Customer benefits and future direction
Chapter 9: Design a Secure Platform using SACChapter Goal: Especially with cloud applications,
Автор: Prasad, Vinayak K. Cifu, Adam S. Название: Ending medical reversal ISBN: 1421429047 ISBN-13(EAN): 9781421429045 Издательство: Неизвестно Рейтинг: Цена: 4455.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Why medicine adopts ineffective or harmful medical practices only to abandon them--sometimes too late.
Medications such as Vioxx and procedures such as vertebroplasty for back pain are among the medical advances that turned out to be dangerous or useless. What Dr. Vinayak K. Prasad and Dr. Adam S. Cifu call medical reversal happens when doctors start using a medication, procedure, or diagnostic tool without a robust evidence base--and then stop using it when it is found not to help, or even to harm, patients.
In Ending Medical Reversal, Drs. Prasad and Cifu narrate fascinating stories from every corner of medicine to explore why medical reversals occur, how they are harmful, and what can be done to avoid them. They explore the difference between medical innovations that improve care and those that only appear to be promising. They also outline a comprehensive plan to reform medical education, research funding and protocols, and the process for approving new drugs that will ensure that more of what gets done in doctors' offices and hospitals is truly effective.
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