Molecular and physiological mechanisms of muscle contraction, Morel, Jean Emile
Автор: Sugi, Haruo (teikyo University, Saitamaken, Japan) Название: Mysteries in muscle contraction ISBN: 9814774480 ISBN-13(EAN): 9789814774482 Издательство: Taylor&Francis Рейтинг: Цена: 21284.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This book explores the author's wide-ranging work on muscle research, which spans more than 50 years. It delves into the dogmas of muscle contraction: how the models were constructed and what was overlooked during the process, including their resulting shortcomings. The text stimulates general readers' and researchers' interest, highlights the author's pioneering work on the electron microscopic recording of myosin head power and recovery strokes, and presents a frank discussion on how the original work sometimes tends to be overlooked by competing scientists, who hinder the progress of science.
Автор: David Aitchison Smith Название: The Sliding-Filament Theory of Muscle Contraction ISBN: 3030035255 ISBN-13(EAN): 9783030035259 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Нет в наличии.
Описание: Understanding the molecular mechanism of muscle contraction started with the discovery that striated muscle is composed of interdigitating filaments which slide against each other. Sliding filaments and the working-stroke mechanism provide the framework for individual myosin motors to act in parallel, generating tension and loaded shortening with an efficient use of chemical energy. Our knowledge of this exquisitely structured molecular machine has exploded in the last four decades, thanks to a bewildering array of techniques for studying intact muscle, muscle fibres, myofibrils and single myosin molecules. After reviewing the mechanical and biochemical background, this monograph shows how old and new experimental discoveries can be modelled, interpreted and incorporated into a coherent mathematical theory of contractility at the molecular level. The theory is applied to steady-state and transient phenomena in muscle fibres, wing-beat oscillations in insect flight muscle, motility assays and single-molecule experiments with optical trapping. Such a synthesis addresses major issues, most notably whether a single myosin motor is driven by a working stroke or a ratchet mechanism, how the working stroke is coupled to phosphate release, and whether one cycle of attachment is driven by the hydrolysis of one molecule of ATP. Ways in which the theory can be extended are explored in appendices.A separate theory is required for the cooperative regulation of muscle by calcium via tropomyosin and troponin on actin filaments. The book reviews the evolution of models for actin-based regulation, culminating in a model motivated by cryo-EM studies where tropomyosin protomers are linked to form a continuous flexible chain. It also explores muscle behaviour as a function of calcium level, including emergent phenomena such as spontaneous oscillatory contractions and direct myosin regulation by its regulatory light chains. Contraction models can be extended to all levels of calcium-activation by embedding them in a cooperative theory of thin-filament regulation, and a method for achieving this grand synthesis is proposed.Dr. David Aitchison Smith is a theoretical physicist with thirty years of research experience in modelling muscle contractility, in collaboration with experimental groups in different laboratories.
Автор: H. Sugi; A.M. Gordon; T.J. Itoh; R. Kamiya; I. Mab Название: Muscle Contraction and Cell Motility ISBN: 3642769292 ISBN-13(EAN): 9783642769290 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume intends to provide a comprehensive overview on the mecha- nisms of muscle contraction and non-muscle cell motility at the molecu- lar and cellular level, not only for investigators in these fields but also for general readers interested in these topics.
Автор: Johann C. R?egg Название: Calcium in Muscle Contraction ISBN: 3642775624 ISBN-13(EAN): 9783642775628 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Recent years have witnessed an explosion of knowledge lea-ding to a molecular understanding of the mechanisms of ac-tion of calcium on excitation and contraction coupling andits role in the regulation of contractility.
Автор: Gerald Pollack Название: Contractile Mechanisms in Muscle ISBN: 146844705X ISBN-13(EAN): 9781468447057 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Prior to the emergence of the sliding filament model, contraction theories had been in abundance. in which filament sliding is presumed to be driven by the cyclic interaction of cross-bridges with complementary actin sites located along the thin filaments.
Описание: It is also possible that contractile vacuoles originate by some form of phase separation not yet understood and possibly involving the contractile properties of proteins, and' it is possible that this process continues to operate in the walls of the vacuoles or feeder canals. This secretory process may be the function of that part of the vacuolar apparatus which blackens on impregnation with osmic acid, and which seems to possess some degree of permanence from vacuole to vacuole and in some cases from parent to daughter cell. Remarkably little is known about the mechanism of systole. General body turgor may contribute, but it is not essential. In ciliates the main force is local and probably comes from a tension in the wall of the vacuole itself, but it is not known whether or not this is an active contraction of an oriented protein layer. The critical process for the initiation of systole is probably the opening of the pore. It is possible that in ciliates there is a rhythmically operating independent timing mechani, sm by which the vacuolar cycle is controlled, but its existence has not been demonstrated
Описание: Physiological Mechanisms and Adaptation Strategies in Plants under Changing Environment, Volume 2 displays the ways by which plants utilize and integrate many common signals and subsequent pathways to cope with less favourable environmental conditions.
Описание: Physiological Mechanisms and Adaptation Strategies in Plants under Changing Environment, Volume 2 displays the ways by which plants utilize and integrate many common signals and subsequent pathways to cope with less favourable environmental conditions.
Автор: Ahmad Parvaiz Название: Physiological Mechanisms and Adaptation Strategies in Plants ISBN: 1461485908 ISBN-13(EAN): 9781461485902 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume illuminates how plants bombarded by diverse environmental stimuli, undergo physiological alterations that enable their survival. The information covered is also useful in building apposite strategies to counter abiotic and biotic stresses.
Описание: This volume illuminates how plants bombarded by diverse environmental stimuli, undergo physiological alterations that enable their survival. The information covered is also useful in building apposite strategies to counter abiotic and biotic stresses.
Описание: Sunscreens are universally recommended by dermatologists not only to prevent the immediate effects of overexposure to sunlight but also to prevent skin cancer.
Автор: Hasso 04Scholz; Masao Endoh; Toshihiko Iijima; Mar Название: Molecular and Cellular Mechanisms of Cardiovascular Regulation ISBN: 443170180X ISBN-13(EAN): 9784431701804 Издательство: Springer Рейтинг: Цена: 12157.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume contains selected papers presented at the Sendai International Sympo- sium on Molecular and Cellular Mechanisms of Cardiovascular Regulation held from May 10-12, 1995, to honor the contributions ofProfessorNorio Taira, Chairman of the Department of Pharmacology (1972-1995), Tohoku University School of Medicine, Sendai, Japan.
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