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Artificial Intelligence Platform for Molecular Targeted Therapy: A Translational Science Approach, Ariel Fernбndez


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Цена: 20592.00р.
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Автор: Ariel Fernбndez
Название:  Artificial Intelligence Platform for Molecular Targeted Therapy: A Translational Science Approach
ISBN: 9789811232305
Издательство: World Scientific Publishing
Классификация:
ISBN-10: 981123230X
Обложка/Формат: Hardback
Страницы: 468
Вес: 0.79 кг.
Дата издания: 08.04.2021
Серия: Medicine
Язык: English
Размер: 229 x 152 x 24
Читательская аудитория: Tertiary education (us: college)
Ключевые слова: Biomedical engineering, COMPUTERS / Intelligence (AI) & Semantics,SCIENCE / Biotechnology,TECHNOLOGY & ENGINEERING / Biomedical
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Поставляется из: Англии
Описание: In the era of big biomedical data, there are many ways in which artificial intelligence (AI) is likely to broaden the technological base of the pharmaceutical industry. Cheminformatic applications of AI involving the parsing of chemical space are already being implemented to infer compound properties and activity. By contrast, dynamic aspects of the design of drug/target interfaces have received little attention due to the inherent difficulties in dealing with physical phenomena that often do not conform to simplifying views.This book focuses precisely on dynamic drug/target interfaces and argues that the true game change in pharmaceutical discovery will come as AI is enabled to solve core problems in molecular biophysics that are intimately related to rational drug design and drug discovery.Here are a few examples to convey the flavor of our quest: How do we therapeutically impair a dysfunctional protein with unknown structure or regulation but known to be a culprit of disease? In regards to SARS-CoV-2, what is the structural impact of a dominant mutation?, how does the structure change translate into a fitness advantage?, what new therapeutic opportunity arises? How do we extend molecular dynamics simulations to realistic timescales, to capture the rare events associated with drug targeting in vivo? How do we control specificity in drug design to selectively remove side effects? This is the type of problems, directly related to the understanding of drug/target interfaces, that the book squarely addresses by leveraging a comprehensive AI-empowered approach.


Biomaterials in Translational Medicine

Автор: Yang, Lei
Название: Biomaterials in Translational Medicine
ISBN: 0128134771 ISBN-13(EAN): 9780128134771
Издательство: Elsevier Science
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Цена: 29476.00 р.
Наличие на складе: Поставка под заказ.

Описание:

Translational Medicine: A Biomaterials Approach delivers timely and detailed information on the latest advances in biomaterials and their role and impact in translational medicine. Key topics addressed include the properties and functions of these materials and how they might be applied for clinical diagnosis and treatment. Particular emphasis is placed on basic fundamentals, biomaterial formulations, design principles, fabrication techniques and transitioning bench-to-bed clinical applications. The book is an essential reference resource for researchers, clinicians, materials scientists, engineers and anyone involved in the future development of innovative biomaterials that drive advancement in translational medicine.

  • Systematically introduces the fundamental principles, rationales and methodologies of creating or improving biomaterials in the context of translational medicine
  • Includes the translational or commercialization status of these new biomaterials
  • Provides the reader with enough background knowledge for a fundamental grip of the difficulties and technicalities of using biomaterial translational medicine
  • Directs the reader on how to find other up-to-date sources (i.e. peer reviewed journals) in the field of translational medicine and biomaterials
Cell Biology and Translational Medicine, Volume 5: Stem Cells: Translational Science to Therapy

Автор: Turksen Kursad
Название: Cell Biology and Translational Medicine, Volume 5: Stem Cells: Translational Science to Therapy
ISBN: 303017591X ISBN-13(EAN): 9783030175917
Издательство: Springer
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Цена: 13974.00 р.
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Описание:

Benjamin W. Streeter, Michael E. Davis Therapeutic Cardiac Patches for Repairing the Myocardium

Nidheesh Dadheech and AM James Shapiro Human Induced Pluripotent Stem Cells in the Curative Treatment of Diabetes and Potential Impediments Ahead

Selami Demirci, PhD, Alexis Leonard, MD, Juan J. Haro-Mora, PhD, Naoya Uchida, MD, PhD and John F Tisdale, MD CRISPR/Cas9 for Sickle Cell Disease: Applications, Future possibilities, and Challenges

David Richards, Joe Swift, Lu Shin Wong, Stephen M. Richardson; Photoresponsive Hydrogels with Photoswitchable Stiffness: Emerging Platforms to Study Temporal Aspects of Mesenchymal Stem Cell Responses to Extracellular Stiffness Regulation

Isabel Calejo, Raquel Costa-Almeida, Manuela E. Gomes; Cellular complexity at the interface: Challenges in enthesis tissue engineering

BURCU TALUG AND ZEYNEP TOKCAER KESKIN; Induced Pluripotent Stem Cells in Disease Modelling and Regeneration

Ayşegьl Mendi, Hacer Ulutьrk, Mustafa Sancar Ataз, Derviş Yılmaz; Stem cells for the oromaxillofacial area: Could they be a promising source for regeneration in dentistry?

Safa AYDIN, Fikrettin ŞAHİN; Stem Cells Derived from Dental Tissues

Hьseyin Abdik, Ezgi Avsar Abdik, Ayşen Aslı Hızlı Deniz, Pakize Neslihan Taşlı, Fikrettin Şahin; A Novel Virtue in Stem Cell Research: Exosomes and Their Role in Differentiation

Taha Bartu Hayal, Binnur Kıratlı, Hatice Burcu Şişli, Fikrettin Şahin, Ayşegьl Doğan; Mesenchymal Stem Cells as Regulators of Carcinogenesis

Frontiers in Biophotonics for Translational Medicine

Автор: Malini Olivo; U. S. Dinish
Название: Frontiers in Biophotonics for Translational Medicine
ISBN: 981287626X ISBN-13(EAN): 9789812876263
Издательство: Springer
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Цена: 20896.00 р.
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Описание:

Fluorescence Lifetime Spectroscopy and Imaging Techniques in Medical Applications.- Translational Photoacoustic Microscopy.- Advances in Optoacoustic Imaging: From Benchside to Clinic.- Raman Spectroscopy Techniques: Developments and Applications in Translational Medicine.- Deep Tissue Hemodynamic Monitoring Using Diffuse Optical Probes.- High Resolution Optical Coherence Tomography for Bio-imaging.- Handheld Probe-based Dual Mode Ultrasound/Photoacoustics for Biomedical Imaging.- Plasmonic Exosome Biosensors for Medical Diagnostics.- Nanoparticle-enabled Endoscopy: Extending the Frontiers of Diagnosis and Treatment.- Monitoring Free Gas In-situ for Medical Diagnostics Using Laser Spectroscopic Techniques.- Next Frontier in Optical Imaging Techniques for Laparoscopic Surgery: An Industry Perspective.

Transcriptional and Translational Regulation of Stem Cells (Advances in Experimental Medicine and Biology)

Автор: Gary Hime (Editor), Helen Abud (Editor)
Название: Transcriptional and Translational Regulation of Stem Cells (Advances in Experimental Medicine and Biology)
ISBN: 9400766203 ISBN-13(EAN): 9789400766204
Издательство: Springer
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Цена: 23757.00 р.
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Описание: This volume takes two approaches to this topic - (1) illustrating the general principles outlined above through a series of different stem cell examples - embryonic, iPS and adult stem cells, and (2) describing several molecular families that have been shown to have roles in regulation of multiple stem cell populations.

Translational Research and Onco-Omics Applications in the Era of Cancer Personal Genomics

Автор: Erika Ruiz-Garcia; Horacio Astudillo-de la Vega
Название: Translational Research and Onco-Omics Applications in the Era of Cancer Personal Genomics
ISBN: 3030240991 ISBN-13(EAN): 9783030240998
Издательство: Springer
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Цена: 13974.00 р.
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Описание: Being a complex disease that affects millions of people world over, cancer research has assumed great significance. Translational cancer research transforms scientific discoveries in the laboratory into clinical application to reduce incidence of cancer, morbidity and mortality. On the other hand, personalized medicine in cancer is the concept that selection of a treatment should be tailored according to the individual patient’s specific genomic characteristics, including mutations, chromosomal aberrations, protein interactions, and SNPs, and even more, taking into account the inmume system, the metabolism and maybe in the next future also the microbiome.

Cell Biology and Translational Medicine

Автор: Kursad Turksen
Название: Cell Biology and Translational Medicine
ISBN: 303017588X ISBN-13(EAN): 9783030175887
Издательство: Springer
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Цена: 13974.00 р.
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Описание: Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions.

This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature's longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas.

This current book is the fifth volume of a continuing series.

Translational Approach to Heart Failure

Автор: Jozef Bartunek; Marc Vanderheyden
Название: Translational Approach to Heart Failure
ISBN: 1493901931 ISBN-13(EAN): 9781493901937
Издательство: Springer
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Цена: 23508.00 р.
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Описание: This book provides an overview of state-of-the-art management of heart failure. Focusing on how techniques move from lab work through clinical trials and approval, it details the latest updates in pathophysiology and clinical presentation.

Targeting Biofilms in Translational Research, Device Development, and Industrial Sectors

Автор: Williams Dustin L.
Название: Targeting Biofilms in Translational Research, Device Development, and Industrial Sectors
ISBN: 3030306666 ISBN-13(EAN): 9783030306663
Издательство: Springer
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Цена: 20962.00 р.
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Описание:

This book offers a much-needed discussion on the targeting of biofilm-related infections. Chapters include discussions on the impact of biofilm on medical implants, industrial applications, as well as wound and tissue infections. It also offers discussions on regulatory management for industrial sectors and medical environments. Given that there continues to be a paucity of effective antimicrobial products, devices, and coatings in clinical and industrial use that effectively reduce rates of infection or biofilm-related problems, Targeting Biofilms in Translational Research, Device Development, and Industrial Sectors, offers a fresh and much-needed perspective aimed at helping create healthier controlled environments and safer devices.
This comprehensive book is indispensable for industrial and academic translational researchers, device developers, and regulatory experts looking to create more effective antimicrobial products.
Frontiers in Biophotonics for Translational Medicine

Автор: Malini Olivo; U. S. Dinish
Название: Frontiers in Biophotonics for Translational Medicine
ISBN: 9811012466 ISBN-13(EAN): 9789811012464
Издательство: Springer
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Цена: 18284.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание:

Fluorescence Lifetime Spectroscopy and Imaging Techniques in Medical Applications.- Translational Photoacoustic Microscopy.- Advances in Optoacoustic Imaging: From Benchside to Clinic.- Raman Spectroscopy Techniques: Developments and Applications in Translational Medicine.- Deep Tissue Hemodynamic Monitoring Using Diffuse Optical Probes.- High Resolution Optical Coherence Tomography for Bio-imaging.- Handheld Probe-based Dual Mode Ultrasound/Photoacoustics for Biomedical Imaging.- Plasmonic Exosome Biosensors for Medical Diagnostics.- Nanoparticle-enabled Endoscopy: Extending the Frontiers of Diagnosis and Treatment.- Monitoring Free Gas In-situ for Medical Diagnostics Using Laser Spectroscopic Techniques.- Next Frontier in Optical Imaging Techniques for Laparoscopic Surgery: An Industry Perspective.

The Market in Mind: How Financialization Is Shaping Neuroscience, Translational Medicine, and Innovation in Biotechnology

Автор: Robinson Mark Dennis
Название: The Market in Mind: How Financialization Is Shaping Neuroscience, Translational Medicine, and Innovation in Biotechnology
ISBN: 0262536870 ISBN-13(EAN): 9780262536875
Издательство: MIT Press
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Цена: 6772.00 р.
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Описание:

A critical examination of translational medicine, when private risk is transferred to the public sector and university research teams become tech startups for global investors.

A global shift has secretly transformed science and medicine. Starting in 2003, biomedical research in the West has been reshaped by the emergence of translational science and medicine--the idea that the aim of research is to translate findings as quickly as possible into medical products. In The Market in Mind, Mark Dennis Robinson charts this shift, arguing that the new research paradigm has turned university research teams into small biotechnology startups and their industry partners into early-stage investment firms. There is also a larger, surprising consequence from this shift: according to Robinson, translational science and medicine enable biopharmaceutical firms, as part of a broader financial strategy, to outsource the riskiest parts of research to nonprofit universities. Robinson examines the implications of this new configuration. What happens, for example, when universities absorb unknown levels of risk? Robinson argues that in the years since the global financial crisis translational science and medicine has brought about "the financialization of health."

Robinson explores such topics as shareholder anxiety and industry retreat from Alzheimer's and depression research; how laboratory research is understood as health innovation even when there is no product; the emergence of investor networking events as crucial for viewing science in a market context; and the place of patients in research decisions. Although translational medicine justifies itself by the goal of relieving patients' suffering, Robinson finds patients' voices largely marginalized in translational neuroscience.


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