Mitochondria and Anaerobic Energy Metabolism in Eukaryotes: Biochemistry and Evolution, Aloysius G. M. Tielens, Marek Mentel, William F. Martin
Автор: Orrenius Название: Mitochondrial Signaling in Health and Disease ISBN: 1439880026 ISBN-13(EAN): 9781439880029 Издательство: Taylor&Francis Рейтинг: Цена: 29093.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Mitochondria have traditionally been associated with metabolic functions; however recent research has uncovered a central role for these organelles in cell signaling, cell survival, and cell death. Mitochondrial dysfunction is a factor in a myriad of pathophysiological conditions, including age-related neurodegenerative disorders, cancer, metabolic syndrome, and cardiovascular disease. Mitochondrial Signaling in Health and Disease examines themes essential for the maintenance of the mitochondrial redox (reduction-oxidation) energy axis.
With contributions from an impressive cadre of internationally recognized scientists, the book discusses coordinated mitochondrial functions that regulate cell function by discrete signaling pathways. Topics discussed include:
Electron transport and energy production
Mitochondrial biogenesis and dynamics
Mitochondrial signaling
Apoptosis and autophagy
Pharmacology signaling
Epigenetic signaling: mitochondrial methylation and acetylation reactions
An essential resource for life and health scientists as well as pharmaceutical industry professionals, this volume highlights the importance of mitochondrial signaling and its role in establishing a harmonized communication between several cellular compartments. The information in this volume is critical to those developing mitochondrion-targeted therapies aimed at assuaging mitochondrial dysfunction or the specific factors contributing to its dysfunction.
Mitochondria are sometimes called the powerhouses of eukaryotic cells, because mitochondria are the site of ATP synthesis in the cell. ATP is the universal energy currency, it provides the power that runs all other life processes. Humans need oxygen to survive because of ATP synthesis in mitochondria. The sugars from our diet are converted to carbon dioxide in mitochondria in a process that requires oxygen. Just like a fire needs oxygen to burn, our mitochondria need oxygen to make ATP. From textbooks and popular literature one can easily get the impression that all mitochondria require oxygen. But that is not the case. There are many groups of organismsm known that make ATP in mitochondria without the help of oxygen. They have preserved biochemical relicts from the early evolution of eukaryotic cells, which took place during times in Earth history when there was hardly any oxygen avaiable, certainly not enough to breathe. How the anaerobic forms of mitochondria work, in which organisms they occur, and how the eukaryotic anaerobes that possess them fit into the larger picture of rising atmospheric oxygen during Earth history are the topic of this book.
Описание: The new edition focuses on the latest information on mitochondrion-derived organelles, particularly on hydrogenosomes and mitosomes. It has become more and more evident that hydrogenosomes and mitosomes are just two specific members of larger family of organelles derived to various extent from mitochondria due to adaptation to oxygen-poor environment and to the parasitic life style. Since the 1st edition, investigation of free-living protists and commensals has revealed that there is a continuous spectrum of mitochondria-derived organelles from typical aerobic mitochondria, mitochondria with stepwise loss of respiratory chain complexes and with concomitant gain of anaerobic pathways (particularly hydrogenase), via hydrogenosomes and mitosomes to the newly discovered organisms that completely lost mitochondria. Most of the experimental data collected relates to the human pathogens Trichomonas vaginalis harboring hydrogenosomes, and Giardia intestinalis and Entamoeba histolytica with mitosoms. In principle, hydrogenosomes are hydrogen and ATP producing organelles, while the only known function in Giardia mitosomes is synthesis of iron-sulfur clusters, whereas mitosomes of E. histolytica possess the recently discovered sulfur activation pathway. Functions of other unusual mitochondria are mostly predicted based on transcriptomic/genomic analyses as corresponding organisms are not amenable to biochemical studies. Investigations on evolution and function of mitochondria-derived organelles substantially changed conventional views on mitochondrion from textbook models of an oxygen-consuming powerhouse of cells to a large family of organelles, variables in their structure and function in which hydrogenosomes and mitosome represent the most divergent anaerobic members.
Описание: The new edition focuses on the latest information on mitochondrion-derived organelles, particularly on hydrogenosomes and mitosomes. It has become more and more evident that hydrogenosomes and mitosomes are just two specific members of larger family of organelles derived to various extent from mitochondria due to adaptation to oxygen-poor environment and to the parasitic life style. Since the 1st edition, investigation of free-living protists and commensals has revealed that there is a continuous spectrum of mitochondria-derived organelles from typical aerobic mitochondria, mitochondria with stepwise loss of respiratory chain complexes and with concomitant gain of anaerobic pathways (particularly hydrogenase), via hydrogenosomes and mitosomes to the newly discovered organisms that completely lost mitochondria. Most of the experimental data collected relates to the human pathogens Trichomonas vaginalis harboring hydrogenosomes, and Giardia intestinalis and Entamoeba histolytica with mitosoms. In principle, hydrogenosomes are hydrogen and ATP producing organelles, while the only known function in Giardia mitosomes is synthesis of iron-sulfur clusters, whereas mitosomes of E. histolytica possess the recently discovered sulfur activation pathway. Functions of other unusual mitochondria are mostly predicted based on transcriptomic/genomic analyses as corresponding organisms are not amenable to biochemical studies. Investigations on evolution and function of mitochondria-derived organelles substantially changed conventional views on mitochondrion from textbook models of an oxygen-consuming powerhouse of cells to a large family of organelles, variables in their structure and function in which hydrogenosomes and mitosome represent the most divergent anaerobic members.
Автор: Justin C. St. John Название: Mitochondrial DNA, Mitochondria, Disease and Stem Cells ISBN: 1627038671 ISBN-13(EAN): 9781627038676 Издательство: Springer Рейтинг: Цена: 22201.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The reader is then introduced to how mtDNA is transmitted through the oocyte and how stem cells can be used to study mitochondrial biogenesis and mtDNA replication and transcription in undifferentiated pluripotent and differentiating cells and how mitochondria adapt during this process.
Автор: Jorge Cruz-Reyes; Michael W. Gray Название: RNA Metabolism in Mitochondria ISBN: 3030086372 ISBN-13(EAN): 9783030086374 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume focuses on mitochondrial RNA metabolism, emphasizing recent discoveries and technological advances in this fast moving area that increase our understanding of mitochondrial gene function. Topics addressed include the interplay of mitochondria with the nucleus and cytosol, structure-function connections, and relevance to human disease. Mitochondria are the powerhouses of the cell, and a great deal is known about mitochondrial energy metabolism. Less well known is the plethora of amazing mechanisms that have evolved to control expression of mitochondrial genomes. Several RNA processes and machineries in protozoa, plants, flies and humans are discussed, including: transcription and RNA polymerase mechanism; tRNA processing of 5? and 3? ends; mRNA maturation by nucleotide insertion/deletion editing and by RNA splicing; mRNA stability; and RNA import. Specialized factors and ribonucleoproteins (RNPs) examined include pentatricopeptide repeat (PPR) proteins, RNase P, polymerases, helicases, nucleases, editing and repair enzymes. Remarkable features of these processes and factors are either not found outside mitochondria, differ substantially among eukaryotic lineages, or are unique in biology.
Название: RNA metabolism in mitochondria / ISBN: 3319781898 ISBN-13(EAN): 9783319781891 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume focuses on mitochondrial RNA metabolism, emphasizing recent discoveries and technological advances in this fast moving area that increase our understanding of mitochondrial gene function. Several RNA processes and machineries in protozoa, plants, flies and humans are discussed, including: transcription and RNA polymerase mechanism;
Автор: Paul F. Lurquin Название: Genetic Engineering in Eukaryotes ISBN: 1468444956 ISBN-13(EAN): 9781468444957 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Indeed, it was our position that the development of plant cell genetic transformation would benefit from the interactions between a comparatively smaller number of fungal and animal cell experts and a larger number of plant cell specialists representing various aspects of plant molecular genetic research.
Автор: R. Perez-Bercoff Название: Protein Biosynthesis in Eukaryotes ISBN: 1468441264 ISBN-13(EAN): 9781468441260 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Shedding light on the relationship between violence and contemporary society, this volume explores the distinctive but little-known theories of violence in the work of Georges Bataille and Jean Baudrillard, applying these to a range of violent events - events often labelled `inexplicable` - in order to show how even the most extreme of acts can be seen as socially meaningful.
Описание: In recent years several different gene silencing phenomena have been discovered in plants. By providing a comparative update on gene silencing effects in different eukaryotes, this book should stimulate communication among scientists working in diverse areas of eukaryotic gene regulation.
Автор: Karl Esser; Ulrich K?ck; Christine Lang-Hinrichs; Название: Plasmids of Eukaryotes ISBN: 3540157980 ISBN-13(EAN): 9783540157984 Издательство: Springer Рейтинг: Цена: 15672.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This review will not consider plasmids of prokaryotic origin, even though certain bacterial plasmids, such as the tumor-inducing (Ti) plasmids of Agrobacterium tumefaciens, may be intimately associated with transformation of the eukaryotic host.
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