Alzheimer`s Disease: Biology, Biophysics And Computational Models, Don Kulasiri, Jingyi Liang
Автор: Helms, Volkhard Название: Principles of Computational Cell Biology ISBN: 3527333584 ISBN-13(EAN): 9783527333585 Издательство: Wiley Рейтинг: Цена: 11880.00 р. Наличие на складе: Поставка под заказ.
Описание: This successful text, now in its 2nd ed. , provides an ideal introduction into the possibilities of modeling on a cell biology level. It extends the strengths of the first edition even further while keeping faithful to the trusted hands-on concept and keeping math to the minimum.
Автор: Ranganathan Shoba Название: Encyclopedia of Bioinformatics and Computational Biology ISBN: 0128114142 ISBN-13(EAN): 9780128114148 Издательство: Elsevier Science Рейтинг: Цена: 265280.00 р. Наличие на складе: Поставка под заказ.
Описание:
Bioinformatics and Computational Biology (BCB) combine elements of computer science, information technology, mathematics, statistics, and biotechnology, providing the methodology and in silico solutions to mine biological data and processes. In the era of molecular diagnostics, targeted drug design and Big Data for personalized medicine, computational methods for data analysis are essential for biochemistry, biology, biotechnology, pharmacology, biomedical science and computer science as well mathematics and statistics.
Navigating the maze of confusing and often contradictory jargon combined with a plethora of software tools is often confusing for students and researchers alike. This comprehensive and unique resource provides up-to-date theory and application content to address molecular data analysis requirements, with precise definition of terminology, and lucid explanations by experts.
This Encyclopedia comprises three sections, covering Theory, Topics and Applications, with a special focus on Integrative -omics and Systems Biology. The theoretical methodology underpinning BCB are described in the Theory section, with Topics covering traditional areas such as phylogeny, as well as more recent areas such as translational bioinformatics, cheminformatics and environmental informatics. Finally, Applications provides guidance for commonly asked "how to" questions.
Bioinformatics and Computational Biology are essential for making sense of the molecular data from many modern high-throughput studies of mice and men, as well as key model organisms and pathogens. This MRW spans basics to cutting-edge methodologies, authored by leaders in the field, providing an invaluable resource to students as well as scientists, in academia and research institutes as well as biotechnology, biomedical and pharmaceutical industries.
Interdisciplinary and comprehenisve: this work unifies the myriad of computer science, information technology, mathematics, statistics and biotechnology terms and concepts used by scientists working in bioinformatics and computational biology. Written and reviewed by leading experts in the field, it is a unique and authoritative resource
Educational: this work focuses on the main theoretical and methodological concepts before expanding on specific topics and applications. As such, it is accessible to scientists with different backgrounds and provides an invaluable teaching resource
Enhanced content: interactive images, multimedia tools and cross-linking to further resources and databases allow the interested reader to deepen his understanding of specific topics, and find relevant codes and open resources
Описание: Essentials of Computational Chemistry, Second Edition provides a balanced introduction to this dynamic subject. Suitable for both experimentalists and theorists, a wide range of examples and applications are included drawn from all key areas.
Автор: Dillon Patrick F Название: Biophysics A Physiological Approach ISBN: 0521172160 ISBN-13(EAN): 9780521172165 Издательство: Cambridge Academ Рейтинг: Цена: 5988.00 р. 8554.00-30% Наличие на складе: Есть (1 шт.) Описание: Specifically tailored to life science students, this textbook outlines the important physical ideas, equations and examples at the heart of contemporary physiology, along with the organization necessary to understand that knowledge. The equations are designed to help students understand biological principles, with a particular emphasis on human biology.
Автор: Kulasiri Don, He Yao Название: Computational Systems Biology of Synaptic Plasticity ISBN: 1786343371 ISBN-13(EAN): 9781786343376 Издательство: World Scientific Publishing Рейтинг: Цена: 19166.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This book demonstrates the power of mathematical thinking in understanding the biological complexity that exists within the brain. It looks at the latest research on modelling of biochemical pathways within synapses, and provides a clear background for the study of mathematical models related to systems biology. Discussion then focusses on developments in computational models based on networks linked to synaptic plasticity. The models are used to understand memory formation and impairment and they provide a mathematical basis for memory research.
Computational Systems Biology of Synaptic Plasticity is a valuable source of knowledge to postgraduate students and researchers in computational systems biology, and as a reference book for various techniques that are needed in modelling biological processes.
Автор: Fuxreiter Название: Computational Approaches To Protein ISBN: 1466561572 ISBN-13(EAN): 9781466561571 Издательство: Taylor&Francis Рейтинг: Цена: 31390.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
The Latest Developments on the Role of Dynamics in Protein Functions
Computational Approaches to Protein Dynamics: From Quantum to Coarse-Grained Methods presents modern biomolecular computational techniques that address protein flexibility/dynamics at all levels of theory. An international contingent of leading researchers in chemistry, physics, and biology show how these advanced methods provide insights into dynamic aspects of biochemical processes. A particular focus is on intrinsically disordered proteins (IDPs), which lack a well-defined three-dimensional structure and function as dynamic ensembles.
The book covers a wide spectrum of dynamics, from electronic structure-based to coarse-grained techniques via multiscaling at different levels. After an introduction to dynamics and historical overview of basic methodologies, the book addresses the following issues:
Is there a quantitative relationship between enzymatic catalysis and protein dynamics?
Which are the functionally relevant motions of proteins?
How can structural properties and partner recognition mechanisms of IDPs be simulated?
How can we speed up molecular dynamics?
How can we describe conformational ensembles by the synergistic effort of computations and experiments?
While dynamics is now considered essential for interpreting protein action, it is not yet an integral component in establishing structure-function relationships of proteins. Helping to reshape this classical view in biochemistry, this groundbreaking book explores advances in computational methodology and contributes to the new, ensemble way of studying proteins.
This is a book of a series on interdisciplinary topics on the Mathematical and Biological Sciences. The chapters correspond to selected papers on special research themes, which have been presented at BIOMAT 2014 International Symposium on Mathematical and Computational Biology which was held in the Stefan Banach International Mathematical Centre at Bedlewo near Poznan, Poland on November 03 - 07, 2014. The treatment is both pedagogical yet advanced in order to motivate research students as well as to fulfill the requirements of professional practitioners. As in the other volumes of this series, there are new important results on the interdisciplinary fields of mathematical and biological sciences and comprehensive reviews written by prominent scientific leaders of famous research groups.
Описание: This book reflects more than three decades of research on Cellular Automata (CA), and nearly a decade of work on the application of CA to model biological strings, which forms the foundation of `A New Kind of Computational Biology` pioneered by the start-up, CARLBio.
Автор: Schiesser William E Название: Computational Chemotaxis Models For Neurodegenerative Disease ISBN: 9813208910 ISBN-13(EAN): 9789813208919 Издательство: World Scientific Publishing Рейтинг: Цена: 7603.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
The mathematical model presented in this book, based on partial differential equations (PDEs) describing attractant-repellent chemotaxis, is offered for a quantitative analysis of neurodegenerative disease (ND), e.g., Alzheimer's disease (AD). The model is a representation of basic phenomena (mechanisms) for diffusive transport and biochemical kinetics that provides the spatiotemporal distribution of components which could explain the evolution of ND, and is offered with the intended purpose of providing a small step toward the understanding, and possible treatment of ND.
The format and emphasis of the presentation is based on the following elements:
A statement of the PDE system, including initial conditions (ICs), boundary conditions (BCs) and the model parameters.
Algorithms for the calculation of numerical solutions of the PDE system with a minimum of mathematical formality.
A set of R routines for the calculation of numerical solutions, including a detailed explanation of all of the sections of the code. The R routines can be executed after a straightforward download of R, an open-source scientific computing system available from the Internet.
Presentation of the numerical solutions, particularly in graphical (plotted) format to enhance the visualization of the solution.
Summary and conclusions concerning the principal results from the model that might serve as the basis for a next step in the modeling of ND.
In other words, a methodology for numerical PDE modeling is presented that is flexible, open ended and readily implemented on modest computers. If the reader is interested in an alternate model, it might possibly be implemented by: (1) modifying and/or extending the current model (for example, by adding terms to the PDEs or adding additional PDEs), or (2) using the reported routines as a prototype for the model of interest.
These suggestions illustrate an important feature of computer-based modeling, that is, the readily available procedure of numerically experimenting with a model. The current model is offered as only a first step toward the resolution of this urgent medical problem.
Описание: This is a book of a series on interdisciplinary topics on the Biological and Mathematical Sciences. The chapters correspond to selected papers on special research themes, which have been presented at BIOMAT 2013 International Symposium on Mathematical and Computational Biology which was held in the Fields Institute for Research in Mathematical Sciences, Toronto, Ontario, Canada, on November 04 - 08, 2013. The treatment is both pedagogical and advanced in order to motivate research students as well as to fulfill the requirements of professional practitioners. There are comprehensive reviews written by prominent scientific leaders of famous research groups.
This is a book of an international series on interdisciplinary topics of the Mathematical and Biological Sciences. The chapters are related to selected papers on the research themes presented at BIOMAT 2015 International Symposium on Mathematical and Computational Biology which was held in the Roorkee Institute of Technology, in Roorkee, Uttarakhand, India, on November 02-06, 2015. The treatment is both pedagogical and advanced in order to motivate research students to fulfill the requirements of professional practitioners. As in other volumes of this series, there are new important results on the interdisciplinary fields of mathematical and biological sciences and comprehensive reviews written by prominent scientific leaders of famous research groups.
There are new results based on the state of art research in Population Dynamics, on Pattern Recognition of Biological Phenomena, the Mathematical Modelling of Infectious Diseases, Computational Biology, the Dynamic and Geometric Modelling of Biological Phenomena, the Modelling of Physiological Disorders, the Optimal Control Techniques in Mathematical Modelling of Biological Phenomena, the Hydrodynamics and Elasticity of Cell Tissues and Bacterial Growth and the Mathematical Morphology of Biological Structures. All these contributions are also strongly recommended to professionals from other scientific areas aiming to work on these interdisciplinary fields.
Название: Computational Biophysics of the Skin ISBN: 9814463841 ISBN-13(EAN): 9789814463843 Издательство: Taylor&Francis Рейтинг: Цена: 17609.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
The accessibility of the skin in vivo has resulted in the development of non-invasive methods in the past 40 years that offer accurate measurements of skin properties and structures from microscopic to macroscopic levels. However, the mechanisms involved in these properties are still only partly understood. Similar to many other domains, including biomedical engineering, numerical modeling has appeared as a complementary key actor for improving our knowledge of skin physiology.
This book presents, for the first time, the contributions that focus on scientific computing and numerical modeling to offer a deeper understanding of the mechanisms involved in skin physiology. The book is structured around some skin properties and functions, including optical and biomechanical properties and skin barrier function and homeostasis, with--for each of them--several chapters that describe either biological or physical models at different scales.
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