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Physiologically-Based Pharmacokinetic (Pbpk) Modeling and Simulations: Principles, Methods, and Applications in the Pharmaceutical Industry, Peters Sheila Annie


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Автор: Peters Sheila Annie
Название:  Physiologically-Based Pharmacokinetic (Pbpk) Modeling and Simulations: Principles, Methods, and Applications in the Pharmaceutical Industry
ISBN: 9781119497684
Издательство: Wiley
Классификация:


ISBN-10: 111949768X
Обложка/Формат: Hardcover
Страницы: 592
Вес: 0.67 кг.
Дата издания: 08.09.2021
Язык: English
Издание: 2nd edition
Размер: 229 x 152 x 35
Читательская аудитория: Professional & vocational
Подзаголовок: Principles, methods, and applications in the pharmaceutical industry
Ссылка на Издательство: Link
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Поставляется из: Англии
Описание: Physiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations

The first book dedicated to the emerging field of physiologically-based pharmacokinetic modeling (PBPK)

Now in its second edition, Physiologically Based Pharmacokinetic (PBPK) Modelling and Simulations: Principles, Methods, and Applications in the Pharma Industry remains the premier reference book throughout the rapidly growing PBPK user community. Using clear and concise language, author Sheila Annie Peters connects theory with practice as she explores the vast potential of PBPK modeling for improving drug discovery and development.

This fully updated new edition covers key developments in the field of PBPK modelling and simulations that have emerged in recent years. A brand-new section provides case studies in different application areas of PBPK modelling, including drug-drug interaction, genetic polymorphism, renal impairment, and pediatric extrapolation. Additional chapters address topics such as model-informed drug development (MIDD) and expose readers to a wide range of current applications in the field. Throughout the book, substantially revised chapters simplify complex topics and offer a balanced view of both the opportunities and challenges of PBPK modelling. Providing timely and comprehensive coverage of one of the most exciting new areas of pharmaceutical science, this book:

  • Describes the principles behind physiological modeling of pharmacokinetic processes, inter-individual variability, and drug interactions for small molecule drugs and biologics
  • Features a wealth of new figures and case studies of the applications of PBPK modelling along the value chain in drug discovery and development
  • Reflects the latest regulatory guidelines on the reporting of PBPK modelling analysis
  • Includes access to a new companion website containing code, datasets, explanations of case examples in the text, and discussion of key developments in the field
  • Contains a brief overview of the field, end-of-chapter keywords for easy reference, and an extensive bibliography

Physiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations: Principles, Methods, and Applications in the Pharmaceutical Industry, Second Edition is an indispensable single-volume resource for beginning and intermediate practitioners across the pharmaceutical sciences in both industry and academia.



      Старое издание
Physiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations: Principles, Methods, and Applications in the Pharmaceutical Industry

Автор: Peters
Название: Physiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations: Principles, Methods, and Applications in the Pharmaceutical Industry
ISBN: 0470484063 ISBN-13(EAN): 9780470484067
Издательство: Wiley
Цена: 15840.00 р.
Наличие на складе: Поставка под заказ.
Описание: The only book dedicated to physiologically-based pharmacokinetic modeling in pharmaceutical science Physiologically-based pharmacokinetic (PBPK) modeling has become increasingly widespread within the pharmaceutical industry over the last decade, but


Physiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations: Principles, Methods, and Applications in the Pharmaceutical Industry

Автор: Peters
Название: Physiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations: Principles, Methods, and Applications in the Pharmaceutical Industry
ISBN: 0470484063 ISBN-13(EAN): 9780470484067
Издательство: Wiley
Рейтинг:
Цена: 15840.00 р.
Наличие на складе: Поставка под заказ.

Описание: The only book dedicated to physiologically-based pharmacokinetic modeling in pharmaceutical science Physiologically-based pharmacokinetic (PBPK) modeling has become increasingly widespread within the pharmaceutical industry over the last decade, but

Pharmacokinetic-Pharmacodynamic Modeling and Simulation

Автор: Peter L. Bonate
Название: Pharmacokinetic-Pharmacodynamic Modeling and Simulation
ISBN: 1489973869 ISBN-13(EAN): 9781489973863
Издательство: Springer
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Цена: 23058.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: The second edition of the book therefore considerably expands with the addition of three new chapters relating to Bayesian models, Generalized linear and nonlinear mixed effects models, and Principles of simulation.

Simulation For Designing Clinical Trials: A Pharmacokinetic-Pharmacodynamic Modeling Perspective

Автор: Kimko Hui
Название: Simulation For Designing Clinical Trials: A Pharmacokinetic-Pharmacodynamic Modeling Perspective
ISBN: 0824708628 ISBN-13(EAN): 9780824708627
Издательство: Taylor&Francis
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Цена: 27562.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Providing more than just a comprehensive history, critical vocabulary, insightful compilation of motivations, and clear explanation of the state-of-the-art of modern clinical trial simulation, this book supplies a rigorous framework for employing simulation as an experiment, according to a predefined simulation plan, that reflects good simulation practices. The book discusses how to design clinical trials according to their probability for success, techniques to define distributions of virtual subjects' characteristics, methods to determine the sensitivity of the trial design, and the population relationship between dosing schedules and patient response.

Pharmacokinetic-Pharmacodynamic Modeling and Simulation

Автор: Bonate
Название: Pharmacokinetic-Pharmacodynamic Modeling and Simulation
ISBN: 038727197X ISBN-13(EAN): 9780387271972
Издательство: Springer
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Цена: 9357.00 р.
Наличие на складе: Поставка под заказ.

Описание: A natural hierarchy exists in pharmacokinetic-pharmacodynamic modeling culminating in population pharmacokinetic models, which are a specific type of nonlinear mixed effects model. The purpose of this book is to present through theory and example how to develop pharmacokinetic models, both at an individual and population level. In order to do so, however, one must first understand linear models and then build to nonlinear models followed by linear mixed effects models and then ultimately nonlinear mixed effects models. This book develops in that manner – each chapter builds upon previous chapters by first presenting the theory and then illustrating the theory using published data sets and actual data sets that were used in the development of new chemical entities collected by the author during his years in industry. A key feature of the book is the process of modeling. Most books and manuscripts often present the final model never showing how the model evolved. In this book all examples are presented in an evolutionary manner.

Physiologically-Based Pharmacokinetic (Pbpk) Modeling

Автор: Fisher, Jeffrey
Название: Physiologically-Based Pharmacokinetic (Pbpk) Modeling
ISBN: 0128185961 ISBN-13(EAN): 9780128185964
Издательство: Elsevier Science
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Цена: 23075.00 р.
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Описание:

Physiologically Based Pharmacokinetic (PBPK) Modeling: Methods and Applications in Toxicology and Risk Assessment presents foundational principles, advanced techniques and applications of PBPK modeling. Contributions from experts in PBPK modeling cover topics such as pharmacokinetic principles, classical physiological models, the application of physiological models for dose-response and risk assessment, the use of in vitro information, and in silico methods. With end-of-chapter exercises that allow readers to practice and learn the skills associated with PBPK modeling, dose-response, and its applications to safety and risk assessments, this book is a foundational resource that provides practical coverage of PBPK modeling for graduate students, academics, researchers, and more.

  • Provides end-of-chapter exercises to teach hands-on computational tools used in toxicology
  • Supplies computer code and explanations and includes examples of applied models used in regulatory toxicology and research
  • Authored by expert editors and contributors who are among the best PBPK modelers in the world
Comparative Kinetics and Distribution to Target Tissues of Organophosphates Using Physiologically- Based Pharmacokinetic Modeling

Автор: Vermillion Rick E.
Название: Comparative Kinetics and Distribution to Target Tissues of Organophosphates Using Physiologically- Based Pharmacokinetic Modeling
ISBN: 1288368801 ISBN-13(EAN): 9781288368808
Издательство: Неизвестно
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Цена: 10658.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Providing a Theoretical Basis for Nanotoxicity Risk Analysis Departing from Traditional Physiologically-Based Pharmacokinetic Modeling

Автор: Yamamoto Dirk P.
Название: Providing a Theoretical Basis for Nanotoxicity Risk Analysis Departing from Traditional Physiologically-Based Pharmacokinetic Modeling
ISBN: 1249831016 ISBN-13(EAN): 9781249831013
Издательство: Неизвестно
Рейтинг:
Цена: 10658.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Reference Physiological Parameters in Pharmacokinetic Modeling

Название: Reference Physiological Parameters in Pharmacokinetic Modeling
ISBN: 1287327060 ISBN-13(EAN): 9781287327066
Издательство: Неизвестно
Цена: 3632.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Physiological Paramenter Values for Pbpk Models

Название: Physiological Paramenter Values for Pbpk Models
ISBN: 1287222307 ISBN-13(EAN): 9781287222309
Издательство: Неизвестно
Цена: 4000.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: The U.S. Environmental Protection Agency (EPA) was introduced on December 2, 1970 by President Richard Nixon. The a Physical, Chemical, and Biological Treatment Techniques for Industrial Wastes gency is charged with protecting human health and the environment, by writing and enforcing regulations based on laws passed by Congress.

The EPA's struggle to protect health and the environment is seen through each of its official publications. These publications outline new policies, detail problems with enforcing laws, document the need for new legislation, and describe new tactics to use to solve these issues. This collection of publications ranges from historic documents to reports released in the new millennium, and features works like: Bicycle for a Better Environment, Health Effects of Increasing Sulfur Oxides Emissions Draft, and Women and Environmental Health.

Автор: Schoenwald, Ronald D.
Название: Pharmacokinetic Principles of Dosing Adjustments
ISBN: 1138457329 ISBN-13(EAN): 9781138457324
Издательство: Taylor&Francis
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Цена: 17609.00 р.
Наличие на складе: Поставка под заказ.

Описание: This book ultimately prepares the reader with the concepts necessary for the more advanced clinical courses that emphasize therapeutic outcomes and for which the assumption is made that the concepts behind the various approaches to dosing adjustments have been mastered previously.

Mathematical Modeling of Pharmacokinetic Data

Автор: Strauss
Название: Mathematical Modeling of Pharmacokinetic Data
ISBN: 1566762049 ISBN-13(EAN): 9781566762045
Издательство: Taylor&Francis
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Цена: 38280.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: A guide to mathematical modeling and analysis of pharmacokinetic data. It covers methods for maximizing the information obtained from given data. It presents an approach to using the mathematical software tools available so that the investigator may extract the maximum information from a given set of data.

Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis

Автор: David D`Argenio
Название: Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis
ISBN: 0306440288 ISBN-13(EAN): 9780306440281
Издательство: Springer
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Цена: 26120.00 р.
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Описание: Proceedings of the 1990 Biomedical Simulations Resource Workshop, held in Marina del Rey, California, May 18-19, 1990


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