Physiologically-Based Pharmacokinetic (Pbpk) Modeling and Simulations: Principles, Methods, and Applications in the Pharmaceutical Industry, Peters Sheila Annie
Описание: The only book dedicated to physiologically-based pharmacokinetic modeling in pharmaceutical science Physiologically-based pharmacokinetic (PBPK) modeling has become increasingly widespread within the pharmaceutical industry over the last decade, but
Автор: Peter L. Bonate Название: Pharmacokinetic-Pharmacodynamic Modeling and Simulation ISBN: 1489973869 ISBN-13(EAN): 9781489973863 Издательство: Springer Рейтинг: Цена: 23058.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The second edition of the book therefore considerably expands with the addition of three new chapters relating to Bayesian models, Generalized linear and nonlinear mixed effects models, and Principles of simulation.
Описание: Providing more than just a comprehensive history, critical vocabulary, insightful compilation of motivations, and clear explanation of the state-of-the-art of modern clinical trial simulation, this book supplies a rigorous framework for employing simulation as an experiment, according to a predefined simulation plan, that reflects good simulation practices. The book discusses how to design clinical trials according to their probability for success, techniques to define distributions of virtual subjects' characteristics, methods to determine the sensitivity of the trial design, and the population relationship between dosing schedules and patient response.
Описание: A natural hierarchy exists in pharmacokinetic-pharmacodynamic modeling culminating in population pharmacokinetic models, which are a specific type of nonlinear mixed effects model. The purpose of this book is to present through theory and example how to develop pharmacokinetic models, both at an individual and population level. In order to do so, however, one must first understand linear models and then build to nonlinear models followed by linear mixed effects models and then ultimately nonlinear mixed effects models. This book develops in that manner – each chapter builds upon previous chapters by first presenting the theory and then illustrating the theory using published data sets and actual data sets that were used in the development of new chemical entities collected by the author during his years in industry. A key feature of the book is the process of modeling. Most books and manuscripts often present the final model never showing how the model evolved. In this book all examples are presented in an evolutionary manner.
Автор: Fisher, Jeffrey Название: Physiologically-Based Pharmacokinetic (Pbpk) Modeling ISBN: 0128185961 ISBN-13(EAN): 9780128185964 Издательство: Elsevier Science Рейтинг: Цена: 23075.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Physiologically Based Pharmacokinetic (PBPK) Modeling: Methods and Applications in Toxicology and Risk Assessment presents foundational principles, advanced techniques and applications of PBPK modeling. Contributions from experts in PBPK modeling cover topics such as pharmacokinetic principles, classical physiological models, the application of physiological models for dose-response and risk assessment, the use of in vitro information, and in silico methods. With end-of-chapter exercises that allow readers to practice and learn the skills associated with PBPK modeling, dose-response, and its applications to safety and risk assessments, this book is a foundational resource that provides practical coverage of PBPK modeling for graduate students, academics, researchers, and more.
Provides end-of-chapter exercises to teach hands-on computational tools used in toxicology
Supplies computer code and explanations and includes examples of applied models used in regulatory toxicology and research
Authored by expert editors and contributors who are among the best PBPK modelers in the world
Название: Physiological Paramenter Values for Pbpk Models ISBN: 1287222307 ISBN-13(EAN): 9781287222309 Издательство: Неизвестно Цена: 4000.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The U.S. Environmental Protection Agency (EPA) was introduced on December 2, 1970 by President Richard Nixon. The a Physical, Chemical, and Biological Treatment Techniques for Industrial Wastes gency is charged with protecting human health and the environment, by writing and enforcing regulations based on laws passed by Congress.
The EPA's struggle to protect health and the environment is seen through each of its official publications. These publications outline new policies, detail problems with enforcing laws, document the need for new legislation, and describe new tactics to use to solve these issues. This collection of publications ranges from historic documents to reports released in the new millennium, and features works like: Bicycle for a Better Environment, Health Effects of Increasing Sulfur Oxides Emissions Draft, and Women and Environmental Health.
Автор: Schoenwald, Ronald D. Название: Pharmacokinetic Principles of Dosing Adjustments ISBN: 1138457329 ISBN-13(EAN): 9781138457324 Издательство: Taylor&Francis Рейтинг: Цена: 17609.00 р. Наличие на складе: Поставка под заказ.
Описание: This book ultimately prepares the reader with the concepts necessary for the more advanced clinical courses that emphasize therapeutic outcomes and for which the assumption is made that the concepts behind the various approaches to dosing adjustments have been mastered previously.
Автор: Strauss Название: Mathematical Modeling of Pharmacokinetic Data ISBN: 1566762049 ISBN-13(EAN): 9781566762045 Издательство: Taylor&Francis Рейтинг: Цена: 38280.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A guide to mathematical modeling and analysis of pharmacokinetic data. It covers methods for maximizing the information obtained from given data. It presents an approach to using the mathematical software tools available so that the investigator may extract the maximum information from a given set of data.