Illuminating Colorectal Cancer Genomics by Next-Generation Sequencing: A Big Chapter in the Tale, El Bairi Khalid
Автор: Urszula Demkow Название: Clinical Applications for Next Generation Sequencing ISBN: 0128017392 ISBN-13(EAN): 9780128017395 Издательство: Elsevier Science Рейтинг: Цена: 12462.00 р. Наличие на складе: Поставка под заказ.
Описание:
Clinical Applications for Next Generation Sequencing provides readers with an outstanding postgraduate resource to learn about the translational use of NGS in clinical environments.
Rooted in both medical genetics and clinical medicine, the book fills the gap between state-of-the-art technology and evidence-based practice, providing an educational opportunity for users to advance patient care by transferring NGS to the needs of real-world patients.
The book builds an interface between genetic laboratory staff and clinical health workers to not only improve communication, but also strengthen cooperation. Users will find valuable tactics they can use to build a systematic framework for understanding the role of NGS testing in both common and rare diseases and conditions, from prenatal care, like chromosomal abnormalities, up to advanced age problems like dementia.
Автор: Steven R. Head; Phillip Ordoukhanian; Daniel R. Sa Название: Next Generation Sequencing ISBN: 1493975129 ISBN-13(EAN): 9781493975129 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This volume covers a wide range of various fields of research, with the common thread being Next Generation Sequencing (NGS) related methods and applications, as well as analysis and interpretation of the data obtained. Chapters guide readers through the highly dynamic processes of translational and transcriptional profiling of a cell, method to detect copy number alterations (CNAs), targeted sequencing applications, method called "Hi-Plex" to characterize known polymorphic loci, single-cell of DNA or RNA, identify and characterize rare circulating CD4 T cells, and computational pipeline for RNAseq analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and practical, Next Generation Sequencing: Methods and Protocols aims to be useful and informative for further study into this vital field.
Автор: Herring Lancel Название: Pathogenesis, Diagnosis and Management of Colorectal Cancer ISBN: 1632427486 ISBN-13(EAN): 9781632427489 Издательство: Неизвестно Рейтинг: Цена: 22530.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Colorectal cancer refers to the cancer of the rectum or colon. Its symptoms are a change in bowel movement, weight loss, blood in the stool and a persistent state of exhaustion. Consumption of processed meat, red meat and alcohol, lack of physical activity, obesity and smoking are considered risk factors that contribute to the occurrence of this cancer. It can be diagnosed by performing a colonoscopy or sigmoidoscopy, or by a microscopical examination of a tissue sample. A referral medical imaging determines the spread or localization of the disease. Colorectal cancer can be treated through a combination of chemotherapy, radiation therapy, surgery and targeted therapy. Depending on the stage of the tumor and patient's health, treatment can be palliative or done with the intent to cure. The topics covered in this extensive book deal with the core aspects of colorectal cancer. Its aim is to present researches pertaining to the pathogenesis, diagnosis and management of colorectal cancer. It will prove to be immensely beneficial to students and researchers in this field.
Автор: Kim Название: Surgical Treatment of Colorectal Cancer ISBN: 9811338469 ISBN-13(EAN): 9789811338465 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Поставка под заказ.
Описание: This book presents an Asian perspective on how the treatment of colorectal cancer can be optimized and standardized in ways that take into account technological advances and the trend towards individually tailored therapy.
Автор: Guillem Название: Management of Hereditary Colorectal Cancer ISBN: 3030262332 ISBN-13(EAN): 9783030262334 Издательство: Springer Рейтинг: Цена: 9781.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book provides a comprehensive review of the clinical management of hereditary colorectal cancer. The text focuses on six distinct patient groups: patients with early age-of-onset colorectal cancer and adenomas, patients with hamartomatous colorectal polyps, patients afflicted with familial adenomatous polyposis (FAP), patients with attenuated familial adenomatous polyposis (AFAP), patients with MYH associated polyposis (MAP), and patients afflicted with lynch syndrome (LS). Each chapter illustrates how clinicians utilize current technologies in genetic testing, pathological review, and endoscopic, surgical, and chemotherapeutic/immunotherapeutic approaches to manage these patient groups. Topics such as the timing of genetic testing, endoscopic screening and surveillance, prophylactic surgical options and chemo-preventive interventions are also discussed in concise yet precise detail. Written by experts in their fields, Management of Hereditary Colorectal Cancer: A Multidisciplinary Approach is a valuable and timely resource for gastroenterologists, surgeons, genetic counselors, medical oncologists, psychologists, and any health caregivers involved with the management of patients and families afflicted with a hereditary form of colorectal cancer.
Автор: Valle Название: Hereditary Colorectal Cancer ISBN: 3030089487 ISBN-13(EAN): 9783030089481 Издательство: Springer Рейтинг: Цена: 21661.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book provides information on a wide variety of issues ranging from genetics to clinical description of the syndromes, genetic testing and counseling, and clinical management including surveillance, surgical and prophylactic interventions, and chemoprevention. Moreover, current hot issues, such as the identification of novel causal genes and the challenges we face, and the relevance of cancer risk modifiers, both genetic and environmental, are also discussed. This reference book is great for geneticists, oncologists, genetic counselors, researchers, clinicians, surgeons and nurses dedicated to, or interested in, hereditary cancer. The best and most recognized experts in the field have contributed to this project, guaranteeing updated information, accuracy and the discussion of topical issues.
Автор: Valle Название: Hereditary Colorectal Cancer ISBN: 3319742582 ISBN-13(EAN): 9783319742588 Издательство: Springer Рейтинг: Цена: 21661.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book provides information on a wide variety of issues ranging from genetics to clinical description of the syndromes, genetic testing and counseling, and clinical management including surveillance, surgical and prophylactic interventions, and chemoprevention. Moreover, current hot issues, such as the identification of novel causal genes and the challenges we face, and the relevance of cancer risk modifiers, both genetic and environmental, are also discussed. This reference book is great for geneticists, oncologists, genetic counselors, researchers, clinicians, surgeons and nurses dedicated to, or interested in, hereditary cancer. The best and most recognized experts in the field have contributed to this project, guaranteeing updated information, accuracy and the discussion of topical issues.
Автор: Beaulieu Название: Colorectal Cancer ISBN: 1493977644 ISBN-13(EAN): 9781493977642 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume explores the latest developments in the study of the mechanisms, diagnostics, screening methods, and therapeutics of colorectal cancer. The book`s chapters are divided into three parts: the chapters in Part One examine techniques used to study the molecular mechanisms in colorectal cancer development and progression.
Автор: John D. Potter; Noralane M. Lindor (Eds.) Название: Genetics of Colorectal Cancer ISBN: 0387095675 ISBN-13(EAN): 9780387095677 Издательство: Springer Рейтинг: Цена: 32004.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Genetic susceptibility refers to how variations in a person`s genes increase or decrease his or her susceptibility to environmental factors, such as chemicals, radiation and lifestyle (diet and smoking). This book explores various findings in the area of genetic susceptibility to gastrointestinal cancers, focusing on molecular epidemiology.
Автор: Peter Jordan Название: Targeted Therapy of Colorectal Cancer Subtypes ISBN: 3030027708 ISBN-13(EAN): 9783030027704 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Поставка под заказ.
Описание: Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide. Recent years have increased significantly our understanding of the genetic alterations that can underlie CRC, but also unraveled the molecular heterogeneity of the disease. Although a simple correlation between genetic pathways, histopathological features and clinical outcome cannot be established, the heterogeneity of CRC is also an opportunity for the development of targeted therapeutic approaches, able to treat an individual tumor with higher efficiency and less toxic side effects. One CRC subtype is characterized by high mutation rates (MSI-H), DNA methylation changes (CIMP-H), mutation in the BRAF oncogene and occurrence of serrated adenomas in the proximal colon. Other groups prevail in the distal colon and consist of either adenomatous polyps with chromosomal aberrations (CIN) and WNT pathway activation, or carry frequent KRAS mutation and metabolic deregulation, or have strong mesenchymal and infiltrative characteristics. Characterization of driver-mutation events in these CRC subgroups has led to the development of specific drugs targeting, for example, the MAPK pathway, but initial clinical trials have revealed unexpected response rates. The collection of chapters in this volume address the biology of specific CRC subtypes and how these may be targeted to improve precision therapy and clinical benefit for the patients.
Автор: Wei Wu; Hani Choudhry Название: Next Generation Sequencing in Cancer Research ISBN: 1461476445 ISBN-13(EAN): 9781461476443 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book offers an interdisciplinary perspective on applying Next Generation Sequencing (NGS) technology to cancer research, surveying the foundations of the technology and its implications in cancer biology, and introducing single cancer cell sequencing.
Автор: Wei Wu; Hani Choudhry Название: Next Generation Sequencing in Cancer Research, Volume 2 ISBN: 3319158104 ISBN-13(EAN): 9783319158105 Издательство: Springer Рейтинг: Цена: 25155.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Latest generation sequencing revolutionizes the fields of cancer research and oncology. This follow-up volume focuses more extensively on single cell sequencing of cancer and trials in drug resistance. A reasonable cancer treatment plan and potential cure is more optimistic now with the unfolding of the cancer genome.
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