1. Notch signalling and embryology: an introduction
2. Notch signaling and embryonic development: an ancient friend, revisited
3. The Five Faces of Notch Signalling During Drosophila melanogaster Embryonic CNS Development
4. Epigenetic regulation of Notch signaling during Drosophila development
5. Regulation of proneural wave propagation through a combination of Notch-mediated lateral inhibition and EGF-mediated reaction diffusion
6. A nucleolar protein, Nepro, is essential for the maintenance of early neural stem cells and preimplantation embryos
7. The role of Notch signaling in leg development in Drosophila melanogaster
8. Notch pathway and inherited diseases: challenge and promise
Index
Автор: I.R. Phillips Название: The Embryology of the Common Marmoset ISBN: 3540079556 ISBN-13(EAN): 9783540079552 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The primates represent a diverse group with the phylogenetic relationships of the var- ious species reflected in their early embryonic development. The members of the Tupaiidae, Lemuridae and Lorisidae show great similarities to the lower mammals and even birds. The Tarsiidae represent an intermediate step and the Platyrrhini and Catarrhini exhibit the greatest similarities to man. During the period of embryogenesis, the dimensions of an embryo are insufficient guide to its age and much more reliable information can be derived from a study of its external form and internal structure. Examination of embryological specimens from a variety of simian species dates back to the early 1900's but much of this material was collected in a haphazard way from animals shot in the wild. Heuser and Streeter (1941) depicted a series of embryos of the rhesus monkey (Macaca mulatta) and correlated their gestational age with external form and size. Streeter (1951) arranged human em- bryos, between 24. 1 and 47. 1 days of post-ovulation age, into age groups or devel- opmental horizons based on their external form and internal structure. Each horizon was two days apart and numbered XI to XXIII. The transition from embryo to fetus occurred at the end of horizon XXIII and was arbitrarily dermed as the point where bone marrow invaded the cartilaginous precursor in the humerus. The earlier stages I-X have been dermed subsequently, (Heuser and Corner, 1957; O'Rahilly, 1973).
Автор: Mark Lewandoski Название: Mouse Molecular Embryology ISBN: 1489977732 ISBN-13(EAN): 9781489977731 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In Mouse Molecular Embryology: Methods and Protocols, expert researchers in the field detail many of the protocols used to study mouse embryology. These include protocols and techniques that are "close to the embryo": such as, manipulating embryonic gene expression, culturing explanted embryonic tissue and harvesting embryonic RNA. With additional chapters on fluorescence imaging, lineage tracing, and genetic ablation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Mouse Molecular Embryology: Methods and Protocols seeks to aid scientist in the further study of mouse embryo and its relation to other aspects of biological research.
Описание: This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer.
Автор: Koji Yasutomo Название: Notch Signaling ISBN: 9811352801 ISBN-13(EAN): 9789811352805 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Поставка под заказ.
Описание: Also, the studies regarding the functions of Notch in immune cells and tumor cells have motivated researchers and pharmaceutical companies to develop drugs for treating immune-mediated diseases and tumors.
Автор: Hugo J. Bellen; Shinya Yamamoto Название: Notch Signaling ISBN: 1493955101 ISBN-13(EAN): 9781493955107 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Notch Signaling: Methods and Protocols focuses on molecular, biochemical and bioinformatics aspects of Notch signaling.
Автор: Paul Sharpe; Ivor Mason Название: Molecular Embryology ISBN: 1617375659 ISBN-13(EAN): 9781617375651 Издательство: Springer Рейтинг: Цена: 25853.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This new edition offers a comprehensive guide to cutting-edge methods used today across the field of molecular embryology. The book emphasizes the most important methods of experimental molecular biology and the particular advantages of each different species.
Автор: Pereira Lygia V Название: Stem Cells: Promise And Reality ISBN: 9813100184 ISBN-13(EAN): 9789813100183 Издательство: World Scientific Publishing Рейтинг: Цена: 4594.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Stem Cells: Promises and Reality will tell you everything you have always wanted to know about stem cells, but could not understand the field from elsewhere.
Stem cells are the great therapeutic promise of the century, and this evolving field of research and medicine brings with it many legal, ethical and psychological issues that must be discussed by society as a whole.
Written so as to be accessible to general readers as well as specialists, this book explains what stem cells are, and the different aspects of stem cell research and applications. The book will enable the reader to understand the field sufficiently to critically participate in the public debates regarding stem cell research and society and ethics. By the end of the book, the reader will also be able to judge news on the stem cells field, and to discern what are real advances and what are phony treatments.
The main advantage of this book in comparison with other "stem cells for the general public" books is that it assumes the reader knows NOTHING about biology, except what is already common knowledge (for example, that we are made of cells). The book constructs step by step the required basic biology knowledge in order for the reader to understand all the different aspects of stem cells. At the same time that it is thorough in its stem cells-based content, and will keep the reader engaged with its narrative.
Автор: Lucio Miele; Spyros Artavanis-Tsakonas Название: Targeting Notch in Cancer ISBN: 1493988573 ISBN-13(EAN): 9781493988570 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The serendipitously discovered link between developmental biology and cancer, touched of an explosion of discoveries on the role of Notch in human malignancies, including every aspect of cancer biology, from control of differentiation, proliferation and apoptosis in transformed cells to angiogenesis, tumor-stroma interaction and anti-cancer immune responses. A number of observations have revealed that Notch even plays a role in the renewal of cancer stem cells and tumor initiating cells, which are thought to be a major cause of resistance to treatment. Targeting Notch in Cancer will provide researchers, oncologists, pharmacologists and students with a detailed understanding of the intricate cross-talk between Notch and other pathways of therapeutic interest so to better design rational drug combinations for specific diseases and disease subsets.Divided into two parts, Part I describes in detail what we know about the genetics, molecular biology, biochemistry and structural biology of Notch, as well as the role of Notch in such processes as angiogenesis and immune surveillance. Without insights gained from these basic studies, rational targeting of Notch in human disease would be impossible. Part II describes the role of Notch and ongoing experimental therapeutic efforts in the most important subtypes of human cancers, organized in a clinically oriented fashion by organs and systems affected
Автор: B. M. Johri Название: Embryology of Angiosperms ISBN: 3642693040 ISBN-13(EAN): 9783642693045 Издательство: Springer Рейтинг: Цена: 12157.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Hans K. Uhthoff Название: The Embryology of the Human Locomotor System ISBN: 3642753124 ISBN-13(EAN): 9783642753121 Издательство: Springer Рейтинг: Цена: 14365.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The pro- gression of changes taking place during the next 3 weeks is so rapid that at the time when the embryo measures 3 cm, all structures familiar to us are not only easily recognizable, but also already in their anatomical position.
Автор: Taylor Jimmy Название: Embryology and Birth Defects ISBN: 1632414945 ISBN-13(EAN): 9781632414946 Издательство: Неизвестно Цена: 23488.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
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