Leukemia Stem Cells in Hematologic Malignancies, Zhang Haojian, Li Shaoguang
Автор: Haojian Zhang; Shaoguang Li Название: Leukemia Stem Cells in Hematologic Malignancies ISBN: 9811373418 ISBN-13(EAN): 9789811373411 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book introduces readers to the biology of leukemia stem cells (LSCs) and emphasizes the necessity and importance of targeting LSCs in the treatment of hematopoietic malignancies. It addresses the role of leukemia stem cells in different leukemia diseases and molecular signatures, as well as the metabolic and epigenetic regulation of leukemia stem cell function. With regard to solid tumors, a significant number of blood cancers are believed to be derived from leukemia stem cells (LSCs), which are responsible for disease progression, relapse and drug resistance. Consequently, new therapeutic strategies need to be developed by focusing on the complete eradication of LSCs. Given its scope, the book offers a valuable asset for graduate students and scientists in the fields of cell biology and cancer research etc.
Автор: Michal Witt; Malgorzata Dawidowska; Tomasz Szczepa Название: Molecular Aspects of Hematologic Malignancies ISBN: 3642445225 ISBN-13(EAN): 9783642445224 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book surveys the molecular biology of hematologic malignancies in relation to clinical diagnoses, symptoms and therapies, including aspects of applied methodology. Offers up-to-date coverage of the molecular basis of selected hematologic disorders.
Автор: David A. Sallman, Ateefa Chaudhury, Johnny Nguyen, Название: Handbook of Hematologic Malignancies ISBN: 1620700948 ISBN-13(EAN): 9781620700945 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 16610.00 р. Наличие на складе: Нет в наличии.
Описание: Provides a unique, practical, and concise guide focused on the must-know points of diagnosis, prognosis, therapeutic management, and cutting edge clinical trial opportunities for each hematologic malignancy. This comprehensive subspecialty handbook is designed and organised for the busy hematologist, hematologic oncologist, hematopathologist, and trainee.
Автор: Blake Copland Название: Hematologic Malignancies: An Overview ISBN: 1536181242 ISBN-13(EAN): 9781536181241 Издательство: Nova Science Рейтинг: Цена: 32312.00 р. Наличие на складе: Невозможна поставка.
Описание: Ineffective haematopoiesis in bone marrow and peripheral cytopenias are features of bone marrow failure and related syndromes. These diseases can progress to myelodysplastic syndrome, acute myeloid leukaemia, and other malignancies. Acute myeloid leukaemia is a heterogeneous complex malignancy characterized by proliferating myeloblasts in the bone marrow and a diverse range of recurrent molecular aberrations that occur in many different combinations. More specifically, the authors explore the McDonough strain of feline sarcoma virus-related tyrosine kinase 3 receptor mutations present in about 30-35% of acute myeloid leukaemia patients. The way in which the Wnt signalling pathway plays an important role in normal haematopoiesis and its deregulation associated with acute myeloid leukaemia is also discussed. This compilation also explores the importance of residual leukemic cells in disease relapse prognosis, as the new definition of the European LeukemiaNet for complete remission includes minimal or measurable residual disease negativity. Mutations detected in patients with clonal haematopoiesis are addressed, including those which most commonly affect DNMT3A, ASXL1, TET2, JAK2, SF3B1, SRSF2, and TP53 genes that had previously been identified as drivers in various myeloid neoplasms. The authors provide an overview of the roles of extracellular vesicles in multiple myeloma, their capacity as emerging biomarkers, and implications for liquid biopsy for detection and monitoring. The penultimate study focuses on toll-like receptors, which play an essential role in the recognition of invading pathogens via specific microbial molecular motifs, forming a bridge between the innate and adaptive immune responses. In conclusion, this compilation explores PROTACs, proteolysis targeting chimeras, which mediate the degradation of proteins of interest by hijacking the activity of E3-ubiquitin ligases for POI polyubiquitination and subsequent degradation by proteasome.
Автор: Sallman David A., Chaudhury Ateefa, Nguyen Johnny Название: Handbook of Hematologic Malignancies ISBN: 0826149766 ISBN-13(EAN): 9780826149763 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 15365.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A ""go-to"" resource for the busy hematologist, hematologic oncologist, hematopathologist, oncology advanced practice provider, oncology nurse, and trainee. Concisely organised, each chapter provides current, need-to-know points of diagnosis, prognosis, therapeutic management, and clinical trial opportunities for each hematological malignancy.
Автор: Martin S. Tallman; Leo I. Gordon Название: Diagnostic and Therapeutic Advances in Hematologic Malignancies ISBN: 1475782675 ISBN-13(EAN): 9781475782677 Издательство: Springer Рейтинг: Цена: 41925.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Martin S. Tallman; Leo I. Gordon Название: Diagnostic and Therapeutic Advances in Hematologic Malignancies ISBN: 0792382064 ISBN-13(EAN): 9780792382065 Издательство: Springer Рейтинг: Цена: 69738.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The field of medicine relating to haematologic malignancies is one in which advances in therapy have been closely linked to a better understanding of molecular medicine. This text aims to provide practitioners with an understanding of the constantly evolving concepts in this area.
Автор: Steven D Mittelman; Nathan A. Berger Название: Energy Balance and Hematologic Malignancies ISBN: 1489994211 ISBN-13(EAN): 9781489994219 Издательство: Springer Рейтинг: Цена: 19589.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: With 70 per cent of the US population either overweight or obese, hematologic malignancies are on the rise, yet treating them is complicated by the very obesity at their root. This volume analyzes the issues located at the nexus of these pressing issues.
Описание: Through an examination of Algeria`s interactions with the wider world from the beginning of its war of independence to the fall of its first post-colonial regime, Mecca of Revolution provides the Third Worldist perspective on twentieth century international history. Featuring pioneering research on multiple continents, it rejuvenates the fields of diplomatic history and post-colonial studies.
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