Epigenetic Advancements in Cancer, Mishra Manoj K., Bishnupuri Kumar S.
Автор: Johannes Backs, Timothy McKinsey Название: Epigenetics in Cardiac Disease ISBN: 3319414550 ISBN-13(EAN): 9783319414553 Издательство: Springer Рейтинг: Цена: 14673.00 р. 20962.00-30% Наличие на складе: Есть (1 шт.) Описание: This book describes important advances in our understanding of how environmental conditions affect cardiac gene expression through epigenetic mechanisms. Further, it discusses the roles of chromatin modifications (in particular DNA methylation and histone modifications) and of chromatin regulators in the context of cardiac diseases. The book provides readers with an overview of our current understanding of epigenetic regulation in the heart, and will stimulate further research in this exciting field. Edited and written by internationally respected experts, it addresses the needs of professors, students and researchers working in the fields of cardiac biology and epigenetics.
Автор: Manoj K. Mishra; Kumar S. Bishnupuri Название: Epigenetic Advancements in Cancer ISBN: 3319249495 ISBN-13(EAN): 9783319249490 Издательство: Springer Рейтинг: Цена: 19591.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: 1. Role of DNA methylation in the progression and clearance of cancer.- 2. Epigenetical role for RNA in cancer progression.- 3. Epigenetics and its role in prostate cancer.- 4. Epigenetics and ovarian cancer.- 5. Epigenetics and breast cancer.- 6. Epigenetics and thyroid cancer.- 7. Epigenetics and intestinal cancer.- 8. Epigenetics and lung cancer.- 9. Epigenetics and renal cancer.- 10. Epigenetics and cervical cancer.- 11. Epigenetical markers in cancer.- 12. Epigenetical role in pancreatic cancer.
Автор: Moshahid Alam Rizvi, Saurabh Verma, Sumit Kumar Название: Handbook of Research on Advancements in Cancer Therapeutics ISBN: 1799865304 ISBN-13(EAN): 9781799865308 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 62509.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The complexity of cancer demands an integrated approach from both a cancer biology standpoint and a pharmaceutical basis to understand the different anticancer modalities. Current research has been focused on conventional and newer anticancer modalities, recent discoveries in cancer research, and also the advancements in cancer treatment. There is a current need for more research on the advances in cancer therapeutics that bridge the gap between basic research (pharmaceutical drug development processes, regulatory issues, and translational experimentation) and clinical application. Recent promising discoveries such as immunotherapies, promising therapies undergoing clinical trials, synthetic lethality, carbon beam radiation, and other exciting targeted therapies are being studied to improve and advance the studies of modern cancer treatment.
The Handbook of Research on Advancements in Cancer Therapeutics serves as a comprehensive guide in modern cancer treatment by combining and merging the knowledge from both cancer biology and the pharmacology of anticancer modalities. The chapters come from multi-disciplinary backgrounds, including scientists and clinicians from both academia and various industries, to discuss nascent personalized therapies and big data-driven cancer treatment. While highlighting topic areas that include cancer prevention, cancer therapeutics, and cancer treatments through the lenses of technology, medicine/drugs, and alternate therapies, this book is ideally intended for oncologists, radiation oncologists, surgical oncologists, and cancer biologists, along with practitioners, stakeholders, researchers, academicians, and students who are interested in understanding the most fundamental aspects of cancer and the available therapeutic opportunities.
Описание: Chapter 1: Microtubule targeting agents in cancer therapy: Elucidating the underlying molecular mechanisms
Chapter 2: Adenosine signaling pathways as potential therapeutic targets in cancer disease
Chapter 3: Anticancer activities of Hippophae rhamnoides: Journey from Benchtop to the Bedside
Chapter 4: Emerging role of ncRNAs in cancer biology: techniques for diagnostic monitoring and potential ncRNA-based therapies.
Chapter 5: Clinical and translational research on the pathophysiology of several ocular tumors types
Chapter 6: Exosomes and cancer: from diagnosis to therapy
Chapter 7: Blood-based Cancer Detection: Towards Solving Diagnostic Puzzle
Chapter 8: Non-coding RNAs, Critical Therapy Targets against Cancer
Chapter 9: Detection of Virus-caused Cancer in Publicly Available Next Generation Sequencing Data
Chapter 10: TRAIL mediated signaling in prostate cancer:
Index
Автор: Michael L?bbert; Peter A. Jones Название: Epigenetic Therapy of Cancer ISBN: 3662519283 ISBN-13(EAN): 9783662519288 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The growing knowledge about disturbances of epigenetic gene regulation in hematopoietic stem cell disorders is now being translated into treatment approaches that target the epigenetic defects pharmacologically. This book first presents the latest evidence regarding the epigenetic regulation of hematopoietic stem cell differentiation and hemoglobin production. The significance of DNA methylation abnormalities in hematopoietic disorders and of epigenetic disturbances in lung cancer and other solid tumors is then discussed. A major part of the book, however, relates specifically to the translation of basic research and drug development to clinical applications, and in this context both present and future clinical strategies are considered. Individual chapters are devoted to the use of DNA hypomethylating agents and chromatin-modifying agents, and the treatment of hematologic malignancies and solid tumors by means of epigenetic agents is discussed in detail.
Автор: Saldanha, Sabita Название: Epigenetic Mechanisms in Cancer ISBN: 0128095520 ISBN-13(EAN): 9780128095522 Издательство: Elsevier Science Рейтинг: Цена: 19875.00 р. Наличие на складе: Поставка под заказ.
Описание: Epigenetic Mechanisms in Cancer provides a comprehensive analysis of epigenetic signatures that govern disease development, progression and metastasis. Epigenetic signatures dictating tumor etiologies present an opportunity for biomarker identification which has broad potential for improving diagnosis, prognosis, prediction, and risk assessment. This volumes offer a unique evaluation of signature differences in of childhood, sex-specific and race-specific cancers, and in doing so broadly illuminates the scope of epigenetic biomarkers in clinical environments. Chapters detail the major epigenetic process in humans consisting of DNA methylation, histone modifications and microRNAs (miRNAs) involved in the initiation, progression and metastasis of tumors. Also delineated are recent technologies such as next generation sequencing that are used to identify epigenetic profiles (primarily methylation analysis) in samples (normal, benign and cancerous) and which are highly important to the analysis of epigenetic outcomes.
Offers broad coverage that is applicable to audiences in various area of cancer research - population studies, diagnostics, prognosis, prediction, therapy, risk, etc.
Provides critical review analysis of the topics that will clarify and delineate the potential roles of epigenetic signatures in cancer management
Covers basic, as well as, clinical areas of epigenetic mechanisms in tumorigenesis
Features contributions by leading experts in the field
Provides comprehensive coverage of current epigenetic signatures involved in the etiology of various cancers and miRNAs
Автор: L?bbert Название: Epigenetic Therapy of Cancer ISBN: 364238403X ISBN-13(EAN): 9783642384035 Издательство: Springer Рейтинг: Цена: 23058.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book covers the translation of basic research and drug development to clinical applications in the treatment of solid tumors as well as hematologic malignancies and hemoglobinopathy. It examines both present and future clinical strategies.
Автор: Steven Gray Название: Epigenetic Cancer Therapy ISBN: 0128002069 ISBN-13(EAN): 9780128002063 Издательство: Elsevier Science Рейтинг: Цена: 17517.00 р. Наличие на складе: Поставка под заказ.
Описание:
Epigenetic Cancer Therapy unites issues central to a translational audience actively seeking to understand the topic. It is ideal for cancer specialists, including oncologists and clinicians, but also provides valuable information for researchers, academics, students, governments, and decision-makers in the healthcare sector.
The text covers the basic background of the epigenome, aberrant epigenetics, and its potential as a target for cancer therapy, and includes individual chapters on the state of epigenome knowledge in specific cancers (including lung, breast, prostate, liver).
The book encompasses both large-scale intergovernmental initiatives as well as recent findings across cancer stem cells, rational drug design, clinical trials, and chemopreventative strategies. As a whole, the work articulates and raises the profile of epigenetics as a therapeutic option in the future management of cancer.
Автор: Jose Luis Garcia-Gimenez Название: Epigenetic Biomarkers and Diagnostics ISBN: 0128018992 ISBN-13(EAN): 9780128018996 Издательство: Elsevier Science Рейтинг: Цена: 16338.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
"Epigenetic Biomarkers and Diagnostics" comprises 31 chapters contributed by leading active researchers in basic and clinical epigenetics. The book begins with the basis of epigenetic mechanisms and descriptions of epigenetic biomarkers that can be used in clinical diagnostics and prognostics. It goes on to discuss classical methods and next generation sequencing-based technologies to discover and analyze epigenetic biomarkers. The book concludes with an account of DNA methylation, post-translational modifications and noncoding RNAs as the most promising biomarkers for cancer (i.e. breast, lung, colon, etc.), metabolic disorders (i.e. diabetes and obesity), autoimmune diseases, infertility, allergy, infectious diseases, and neurological disorders.
The book describes the challenging aspects of research in epigenetics, and current findings regarding new epigenetic elements and modifiers, providing guidance for researchers interested in the most advanced technologies and tested biomarkers to be used in the clinical diagnosis or prognosis of disease. Focuses on recent progress in several areas of epigenetics, general concepts regarding epigenetics, and the future prospects of this discipline in clinical diagnostics and prognosticsDescribes the importance of the quality of samples and clinical associated data, and also the ethical issues for epigenetic diagnosticsDiscusses the advances in epigenomics technologies, including next-generation sequencing based tools and applicationsExpounds on the utility of epigenetic biomarkers for diagnosis and prognosis of several diseases, highlighting the study of these biomarkers in cancer, cardiovascular and metabolic diseases, infertility, and infectious diseasesIncludes a special section that discusses the relevance of biobanks in the maintenance of high quality biosamples and clinical-associated data, and the relevance of the ethical aspects in epigenetic studies
Название: Nutrition, epigenetic mechanisms, and human disease ISBN: 1439804796 ISBN-13(EAN): 9781439804797 Издательство: Taylor&Francis Рейтинг: Цена: 27562.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
As nutrition research is shifting its focus from epidemiology and physiology to effects of nutrients at the molecular level, a uniquely tailored diet that corresponds to the demands of our genetic signature is emerging as an indispensable need. Using high-throughput genomic tools, nutrigenomics unravels the influence of micro- and macronutrients as potent dietary signals regulating metabolic pathways and unmasks how susceptible genotypes are predisposed to diet-related diseases.
Selected topics from this field have been covered in some books, but no other comprehensive text on epigenetics, nutrition, and human health and disease is available, until now. This book illustrates nutrition's influence on epigenetic inheritance and the mechanisms underlying the modification of the metabolic imprint of an individual. This enriched understanding of nutrigenomics can be applied to master a tailored diet that can alleviate imprinted metabolic syndromes. Specifically, the book focuses on:
Maternal, perinatal, and neonatal nutrition
Epigenetic mechanisms and cancer
Impacts of dietary factors, folate deficiency and DNA methylation
Nutrition's influence on genetic imprinting
The basics of nutrigenomics and epigenetic regulation
