Biophysics of Mitochondria, Vekshin Nikolai

Автор: Lane Nick
Название: Power, Sex, Suicide: Mitochondria and the Meaning of Life
ISBN: 0198831900 ISBN-13(EAN): 9780198831907
Издательство: Oxford Academ
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Описание: Mitochondria are tiny structures within all our cells, believed to have once evolved from bacteria living independent lives. Drawing on cutting edge research, this book explores the fundamental role they play in some of the biggest themes in biology: evolution, the origin of the sexes, in growth, ageing, disease, and in death.

Автор: Jiri Neuzil; Shazib Pervaiz; Simone Fulda
Название: Mitochondria: The Anti- cancer Target for the Third Millennium
ISBN: 9402403493 ISBN-13(EAN): 9789402403497
Издательство: Springer
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Цена: 27950.00 р.
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Описание: This book will be focused on mitochondria as very promising targets for anti-cancer drugs, yet to be fully exploited. It will contain chapters focused on aspects of basic research as well as on clinical relevance, which will be written by specialists in the field. That the role of mitochondria in human pathologies goes beyond the neoplastic diseases will be documented by a chapter of the role of mitochondria in Friedreich's ataxia.

Автор: Mokranjac Dejana, Perocchi Fabiana
Название: Mitochondria: Practical Protocols
ISBN: 1493983091 ISBN-13(EAN): 9781493983094
Издательство: Springer
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Описание:

A Guide to Computational Methods for Predicting Mitochondrial Localization.- Isolation of Functional Mitochondria from Cultured Cells and Mouse Tissues.- Isolation of Mitochondria From Saccharomyces Cerevisiae.- Isolation of Contact Sites Between Inner and Outer Mitochondrial Membranes.- Isolation Of Mitochondria-Associated Membranes (MAM) from Mouse Brain Tissue.- Label-Free Quantitative Analysis of Mitochondrial Proteomes using the Multienzyme Digestion-Filter Aided Sample Preparation (MED-FASP) and 'Total Protein Approach'.- Quantitative Analysis of Glycerophospholipids in Mitochondria by Mass Spectrometry.- Detection of Cysteine Redox States in Mitochondrial Proteins in Intact Mammalian Cells.- Chemical Crosslinking in Intact Mitochondria.- Reconstitution of Mitochondrial Membrane Proteins into Nanodiscs by Cell-Free Expression.- Detection of Dual Targeting and Dual Function of Mitochondrial Proteins in Yeast.- Localizing Mrnas Encoding Mitochondrial Proteins in Yeast by Fluorescence Microscopy and Subcellular Fractionation.- Assessing Mitochondrial Bioenergetics in Isolated Mitochondria from Various Mouse Tissues using Seahorse XF96 Analyzer.- Application of FRET-Based Biosensor "Ateam" for Visualization of ATP Levels in the Mitochondrial Matrix of Living Mammalian Cells.- A Microplate-Based Bioluminescence Assay of Mitochondrial Calcium Uptake.- New Imaging Tools to Analyze Mitochondrial Morphology in Caenorhabditis Elegans.- Single Molecule Tracking and Localization Of Mitochondrial Protein Complexes in Live Cells.- Analysis of Yeast Mitochondria by Electron Microscopy.- Analysis of Mitochondrial Membrane Protein Complexes by Electron Cryo-Tomography.- Assays for Mitophagy in Yeast.- Assessing Mitochondrial Selective Autophagy in the Nematode Caenorhabditis Elegans.- Assessing Mitochondrial Unfolded Protein Response in Mammalian Cells.- Analysis of Mitochondrial RNA-Processing Defects in Patient-Derived Tissues by Qrt-PCR and Rnaseq.- Identification of Disease-Causing Mutations by Functional Complementation of Patient-Derived Fibroblast Cell Lines.

Автор: Harpreet Singh; Shey-Shing Sheu
Название: Pharmacology of Mitochondria
ISBN: 3319861301 ISBN-13(EAN): 9783319861302
Издательство: Springer
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Цена: 39130.00 р.
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Описание: This special book is conceived to highlight mitochondrial structural and functional integrity and how they are associated with several human diseases such as cardiovascular, cancer, renal, neurological disorder, and genetic disorders.

Автор: Hockenbery David M.
Название: Mitochondria and Cell Death
ISBN: 1493980947 ISBN-13(EAN): 9781493980949
Издательство: Springer
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Цена: 20962.00 р.
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Описание: This volume examines the role of mitochondria in different types of cell death, including apoptotic and necrotic cell deaths. Topics discussed include mitochondrial outer membrane permeabilization (MOMP) and the permeability transition pore; core processes such as calcium handling, fission and fusion, reactive oxygen species generation, and maintenance of mitochondrial DNA fidelity and protein folding homeostasis; and retrograde signaling between mitochondria and other cellular components, including the important role of mitochondria in antiviral immunity. The expertly authored chapters are drawn from multidisciplinary international perspectives, lending a nuanced and comprehensive approach to the material. Mitochondria and Cell Death, part of the Cell Death in Biology and Diseases series, is invaluable reading for graduate students, researchers, and clinicians in the fields of neuroscience, oncology, gastroenterology, and hepatology, as well as those interested in the study of mitochondria and cell biology.

Автор: Justin C. St. John
Название: Mitochondrial DNA, Mitochondria, Disease and Stem Cells
ISBN: 1627038671 ISBN-13(EAN): 9781627038676
Издательство: Springer
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Цена: 22201.00 р.
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Описание: The reader is then introduced to how mtDNA is transmitted through the oocyte and how stem cells can be used to study mitochondrial biogenesis and mtDNA replication and transcription in undifferentiated pluripotent and differentiating cells and how mitochondria adapt during this process.

Автор: Vekshin Nikolai
Название: Biophysics of Mitochondria
ISBN: 303033855X ISBN-13(EAN): 9783030338558
Издательство: Springer
Цена: 22174.00 р.
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Описание: In this monograph, the author -Head researcher at the Institute of Cell Biophysics of Russian Academy of Sciences- discusses the results of his own long-term studies of mitochondria as well as alternative points of view and experiments of other important researchers in the field.

Автор: Dhyan Chandra
Название: Mitochondria as Targets for Phytochemicals in Cancer Prevention and Therapy
ISBN: 1493953249 ISBN-13(EAN): 9781493953240
Издательство: Springer
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Цена: 19589.00 р.
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Описание: The second part focuses on the elucidation of key target proteins that could be exploited for cancer prevention, an the role of phytochemicals in cancer prevention, updates on basic research related to phytochemicals action critical for cancer prevention, and updates on translational knowledge on cancer prevention by phytochemicals.

Автор: Jan Tachezy
Название: Hydrogenosomes and Mitosomes: Mitochondria of Anaerobic Eukaryotes
ISBN: 3030179400 ISBN-13(EAN): 9783030179403
Издательство: Springer
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Цена: 20962.00 р.
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Описание: The new edition focuses on the latest information on mitochondrion-derived organelles, particularly on hydrogenosomes and mitosomes. It has become more and more evident that hydrogenosomes and mitosomes are just two specific members of larger family of organelles derived to various extent from mitochondria due to adaptation to oxygen-poor environment and to the parasitic life style. Since the 1st edition, investigation of free-living protists and commensals has revealed that there is a continuous spectrum of mitochondria-derived organelles from typical aerobic mitochondria, mitochondria with stepwise loss of respiratory chain complexes and with concomitant gain of anaerobic pathways (particularly hydrogenase), via hydrogenosomes and mitosomes to the newly discovered organisms that completely lost mitochondria. Most of the experimental data collected relates to the human pathogens Trichomonas vaginalis harboring hydrogenosomes, and Giardia intestinalis and Entamoeba histolytica with mitosoms. In principle, hydrogenosomes are hydrogen and ATP producing organelles, while the only known function in Giardia mitosomes is synthesis of iron-sulfur clusters, whereas mitosomes of E. histolytica possess the recently discovered sulfur activation pathway. Functions of other unusual mitochondria are mostly predicted based on transcriptomic/genomic analyses as corresponding organisms are not amenable to biochemical studies. Investigations on evolution and function of mitochondria-derived organelles substantially changed conventional views on mitochondrion from textbook models of an oxygen-consuming powerhouse of cells to a large family of organelles, variables in their structure and function in which hydrogenosomes and mitosome represent the most divergent anaerobic members.

Автор: Weissig Volkmar, Edeas Marvin
Название: Mitochondrial Medicine: Volume 2: Assessing Mitochondria
ISBN: 1071612654 ISBN-13(EAN): 9781071612651
Издательство: Springer
Цена: 16769.00 р.
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Описание:

1. Mitochondrial Dysfunction in Mitochondrial Medicine: Current Limitations, Pitfalls, and Tomorrow

Shima Mehrvar, Amadou K. S. Cama

Автор: James Whelan; Monika W. Murcha
Название: Plant Mitochondria
ISBN: 1493926381 ISBN-13(EAN): 9781493926381
Издательство: Springer
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Цена: 19564.00 р.
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Описание: The chapters compiled in this detailed collection outline a number of methods used to study plant mitochondria today, starting from the isolation of mitochondria to detailed analyses of RNA, protein and enzymatic activities.