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Heterogeneity in Statistical Genetics: How to Assess, Address, and Account for Mixtures in Association Studies, Gordon Derek, Finch Stephen J., Kim Wonkuk


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Автор: Gordon Derek, Finch Stephen J., Kim Wonkuk
Название:  Heterogeneity in Statistical Genetics: How to Assess, Address, and Account for Mixtures in Association Studies
ISBN: 9783030611200
Издательство: Springer
Классификация:


ISBN-10: 3030611205
Обложка/Формат: Hardcover
Страницы: 352
Вес: 0.70 кг.
Дата издания: 01.02.2021
Серия: Statistics for biology and health
Язык: English
Издание: 1st ed. 2020
Иллюстрации: 25 tables, color; 26 illustrations, color; 15 illustrations, black and white; xx, 352 p. 41 illus., 26 illus. in color.
Размер: 23.39 x 15.60 x 2.24 cm
Читательская аудитория: Professional & vocational
Подзаголовок: How to assess, address, and account for mixtures in association studies
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: Heterogeneity, or mixtures, are ubiquitous in genetics. Even for data as simple as mono-genic diseases, populations are a mixture of affected and unaffected individuals. Still, most statistical genetic association analyses, designed to map genes for diseases and other genetic traits, ignore this phenomenon. In this book, we document methods that incorporate heterogeneity into the design and analysis of genetic and genomic association data. Among the key qualities of our developed statistics is that they include mixture parameters as part of the statistic, a unique component for tests of association. A critical feature of this work is the inclusion of at least one heterogeneity parameter when performing statistical power and sample size calculations for tests of genetic association. We anticipate that this book will be useful to researchers who want to estimate heterogeneity in their data, develop or apply genetic association statistics where heterogeneity exists, and accurately evaluate statistical power and sample size for genetic association through the application of robust experimental design.
Дополнительное описание: 1. Introduction to heterogeneity in statistical genetics.- 2. Overview of genomic heterogeneity in statistical genetics.- 3. Phenotypic heterogeneity.- 4. Association tests allowing for heterogeneity.- 5. Designing genetic linkage and association studies



Stem Cells Heterogeneity in Different Organs

Автор: Alexander Birbrair
Название: Stem Cells Heterogeneity in Different Organs
ISBN: 3030241076 ISBN-13(EAN): 9783030241070
Издательство: Springer
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Цена: 25155.00 р.
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Описание:

This book presents a comprehensive discussion on the heterogeneity existing between different types of stem cells within the same tissue. As the functions of these stem cells vary, this is very important for the application of stem cells in cell therapy. This book describes the many recent developments that have revealed completely different roles of distinct stem cells within the same organ.
Stem Cells Heterogeneity in Different Organs provides a timely update on the current information on stem cells heterogeneity in various tissues. It also provides a solid foundation of the history of stem cells from specific tissues and the current applications of this knowledge in regenerative medicine. Taken with its companion volumes, Stem Cells Heterogeneity: Novel Concepts and Stem Cells Heterogeneity in Cancer, this book is essential reading for advanced cell biology students as well as researchers and clinicians working with stem cells.
Stem Cells Heterogeneity in Cancer

Автор: Birbrair Alexander
Название: Stem Cells Heterogeneity in Cancer
ISBN: 3030143686 ISBN-13(EAN): 9783030143688
Издательство: Springer
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Цена: 16070.00 р.
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Описание: This book presents a comprehensive discussion on the heterogeneity existing between different types of stem cells within the same tissue, for several types of cancers, e.g. glioblastoma stem cells. Recent developments have revealed completely different roles of distinct stem cells within the same organ. Thus, Stem Cells Heterogeneity in Cancer provides a timely update us on the current information on stem cells heterogeneity in various tissues. It also provides a solid foundation of the history of stem cells from specific tissues and the current applications of this knowledge in regenerative medicine. When taken as a whole, alongside its companion volumes Stem Cells Heterogeneity – Novel Concepts, and Stem Cells Heterogeneity in Different Organs, these three books present a comprehensive reference on stem cell heterogeneity in various tissues and current and future applications for regenerative medicine. It is essential reading for advanced cell biology students as well as researchers in stem cells and clinicians.

Genetic Toxicology of Complex Mixtures

Автор: Michael D. Waters; F.Bernhard Daniel; Joellen Lewt
Название: Genetic Toxicology of Complex Mixtures
ISBN: 1468458523 ISBN-13(EAN): 9781468458527
Издательство: Springer
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Цена: 6986.00 р.
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Описание: Proceedings of a symposium held in Washington, DC, July 4-7, 1989

Clinical and Molecular Heterogeneity of Osteogenesis Imperfecta

Автор: Meena Balasubramanian
Название: Clinical and Molecular Heterogeneity of Osteogenesis Imperfecta
ISBN: 1615047441 ISBN-13(EAN): 9781615047444
Издательство: Mare Nostrum (Eurospan)
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Цена: 3762.00 р.
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Описание: Osteogenesis imperfecta (OI) is a disease encompassing a group of disorders mainly characterized by bone fragility and is the commonest form of heritable bone fragility. In this book, the clinical presentations with particular emphasis on rare phenotypes associated with OI are discussed together with molecular advances in diagnosis and treatment of OI.

Stem Cells Heterogeneity - Novel Concepts

Автор: Alexander Birbrair
Название: Stem Cells Heterogeneity - Novel Concepts
ISBN: 3030110958 ISBN-13(EAN): 9783030110956
Издательство: Springer
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Цена: 20962.00 р.
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Описание: This book presents a comprehensive discussion on the novel concepts in stem cell heterogeneity, from pluripotent stem cells to human mesenchymal stem cells, adult and cancer stem cells of the thyroid, sarcoma, and more. Thus, Stem Cell Heterogeneity - Novel Concepts starts from a timely update on the current information on stem cells heterogeneity in various tissues and discusses new concepts and future directions. It also provides a solid foundation of the history of stem cells from specific tissues and the current applications of this knowledge in regenerative medicine. When taken as a whole, alongside its companion volumes Stem Cells Heterogeneity in Different Organs, and Stem Cells Heterogeneity in Cancer, these three books present a comprehensive reference on stem cell heterogeneity in various tissues and current and future applications for regenerative medicine. It is essential reading for advanced cell biology students as well as researchers in stem cells and clinicians.

Stem Cells Heterogeneity in Different Organs

Автор: Birbrair Alexander
Название: Stem Cells Heterogeneity in Different Organs
ISBN: 3030241106 ISBN-13(EAN): 9783030241100
Издательство: Springer
Рейтинг:
Цена: 18167.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: This book presents a comprehensive discussion on the heterogeneity existing between different types of stem cells within the same tissue. As the functions of these stem cells vary, this is very important for the application of stem cells in cell therapy. This book describes the many recent developments that have revealed completely different roles of distinct stem cells within the same organ. Stem Cells Heterogeneity in Different Organs provides a timely update on the current information on stem cells heterogeneity in various tissues. It also provides a solid foundation of the history of stem cells from specific tissues and the current applications of this knowledge in regenerative medicine. Taken with its companion volumes, Stem Cells Heterogeneity: Novel Concepts and Stem Cells Heterogeneity in Cancer, this book is essential reading for advanced cell biology students as well as researchers and clinicians working with stem cells.

A Primer on Experiments with Mixtures

Автор: Cornell
Название: A Primer on Experiments with Mixtures
ISBN: 0470643382 ISBN-13(EAN): 9780470643389
Издательство: Wiley
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Цена: 17416.00 р.
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Описание: The concise yet authoritative presentation of key techniques for basic mixtures experiments Inspired by the author`s bestselling advanced book on the topic, A Primer on Experiments with Mixtures provides an introductory presentation of the key principles behind experimenting with mixtures.

Stem Cells Heterogeneity in Cancer

Автор: Alexander Birbrair
Название: Stem Cells Heterogeneity in Cancer
ISBN: 3030143651 ISBN-13(EAN): 9783030143657
Издательство: Springer
Рейтинг:
Цена: 22359.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание:

This book presents a comprehensive discussion on the heterogeneity existing between different types of stem cells within the same tissue, for several types of cancers, e.g. glioblastoma stem cells. Recent developments have revealed completely different roles of distinct stem cells within the same organ.
Thus, Stem Cells Heterogeneity in Cancer provides a timely update us on the current information on stem cells heterogeneity in various tissues. It also provides a solid foundation of the history of stem cells from specific tissues and the current applications of this knowledge in regenerative medicine. When taken as a whole, alongside its companion volumes Stem Cells Heterogeneity – Novel Concepts, and Stem Cells Heterogeneity in Different Organs, these three books present a comprehensive reference on stem cell heterogeneity in various tissues and current and future applications for regenerative medicine. It is essential reading for advanced cell biology students as well as researchers in stem cells and clinicians.
Heterogeneity in the Crust and Upper Mantle

Автор: John A. Goff; Klaus Holliger
Название: Heterogeneity in the Crust and Upper Mantle
ISBN: 1461349249 ISBN-13(EAN): 9781461349242
Издательство: Springer
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Цена: 12577.00 р.
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Описание: Most of our knowledge about the physical structure and the chemical composition of the Earth`s deep interior is inferred from seismic data.


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