Gidday Jeffrey M., Perez-Pinzon Miguel A., Zhang John H. Innate Tolerance in the CNS: Translational Neuroprotection by Pre- And Post-Conditioning 9781493941773

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Автор: Gidday Jeffrey M., Perez-Pinzon Miguel A., Zhang John H.
Название: Innate Tolerance in the CNS: Translational Neuroprotection by Pre- And Post-Conditioning
ISBN: 9781493941773
Издательство: Springer
Классификация:

Неврология и клиническая нейрофизиология

Нейронауки

Зоология и науки о животных

ISBN-10: 1493941771
Обложка/Формат: Paperback
Страницы: 699
Вес: 0.98 кг.
Дата издания: 23.08.2016
Серия: Springer series in translational stroke research
Язык: English
Издание: Softcover reprint of
Иллюстрации: 18 tables, black and white; ix, 699 p.; 18 tables, black and white; ix, 699 p.
Размер: 23.39 x 15.60 x 3.61 cm
Читательская аудитория: General (us: trade)
Подзаголовок: Translational neuroprotection by pre- and post-conditioning
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: Cerebral preconditioning is a phenomenon wherein a mild insult or stress induces cellular and tissue adaptation or tolerance to a later, severe injury, therefore reflecting the efficacy of endogenous mechanisms of cerebrovascular protection. Initially identified for rapid cardiac protection, preconditioning has expanded to all aspects of CNS protection from ischemia, trauma and potentially neurodegeneration. Many different stimuli or stressors have been identified as preconditioning agents, suggesting a downstream convergence of mechanisms and underscoring the potential for translational application of preconditioning in the clinic. Moreover, the fundamental mechanisms responsible for preconditioning-induced tolerance will help in the design novel pharmacological approaches for neuroprotection. While stroke and many other brain injuries are not predictable, in some populations (e.g., metabolic syndrome, patients undergoing carotid endarterectomy, aneurysm clipping, or with recent TIAs) the risk for stroke is identifiable and significant, and preconditioning may represent a useful strategy for neuroprotection. For unpredictable injuries, post-conditioning the brain – or inducing endogenous protective mechanisms after the initial injury – can also abrogate the extent of injury. Finally, remote pre- and post-conditioning methods have been developed in animals, and are now being tested in clinical trials, wherein a brief, noninjurious stress to a noncerebral tissue (i.e., skeletal muscle) can provide protection to the CNS and thereby allows clinicians the opportunity to circumvent concerns regarding the direct preconditioning of neurological tissues.
Дополнительное описание: Preface.- Section I. Comparative Physiology and Historical Background.- 1. Tolerance, Historical Review.- 2. Anoxia resistance in lower and higher vertebrates.- 3. Hibernation: A Natural Model of Tolerance to Cerebral Ischemia/Reperfusion.- 4. Preconditio

Innate Tolerance in the CNS: Translational Neuroprotection by Pre- And Post-Conditioning, Gidday Jeffrey M., Perez-Pinzon Miguel A., Zhang John H.