Non-Canonical Cyclic Nucleotides, Seifert Roland

Автор: Scherman Daniel
Название: Advanced Textbook On Gene Transfer, Gene Therapy And Genetic Pharmacology: Principles, Delivery And Pharmacological And Biomedical Applications Of Nucleotide-based Therapies (Second Edition)
ISBN: 1786346877 ISBN-13(EAN): 9781786346872
Издательство: World Scientific Publishing
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Описание:

This unique advanced textbook provides a clear and comprehensive overview of gene delivery, gene therapy and genetic pharmacology, with descriptions of the main gene transfer vectors and a set of selected therapeutic applications, along with safety considerations. The second edition features new groundbreaking material on genome editing using the recently discovered CRISPR/Cas9 system and on cancer immunotherapy by CAR-T cells. It also presents the historical milestone of gene therapy application in the field of severe combined immunodeficiency, and other fields of gene therapy and molecular medicine.

The use of gene transfer is exponentially growing in the scientific and medical communities for day-to-day cell biology experiments and swift development of gene therapy, which is already revolutionizing medicine. In this advanced textbook, more than 30 leading scientists come together to explore these topics.

This educational introduction provides the background material needed to further explore the subject as well as relevant research literature. It is an invaluable resource to Master, PhD or MD students, post-doctoral scientists or medical doctors, as well as any scientist wishing to deliver a gene or synthetic nucleotide or develop a gene therapy strategy. The second edition's simple and synthetic content will be of value to any reader interested in the biological and medical revolution derived from the elucidation of the human genome.

Автор: Luiz Belardinelli; A. Pelleg
Название: Adenosine and Adenine Nucleotides: From Molecular Biology to Integrative Physiology
ISBN: 0792331907 ISBN-13(EAN): 9780792331902
Издательство: Springer
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Описание: This text contains lectures which cover a range of subjects from molecular and cellular biology to clinical applications. Emphasis has been placed on information derived from studies using molecular and cellular biology techniques applied to the field of adenosine and adenine nucleotide research.

Автор: Roland Seifert
Название: Non-canonical Cyclic Nucleotides
ISBN: 3319526715 ISBN-13(EAN): 9783319526713
Издательство: Springer
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Описание: Lastly, the book will present important methodological aspects ranging from mass-spectrometric methods for cyclic nucleotide detection to the synthesis of nucleotide analogs as experimental tools and holistic methods for analysis of cyclic nucleotide effects.

Автор: J. A. Nathanson; M.M. Appleman; J. W. Kebabian; M.
Название: Cyclic Nucleotides
ISBN: 3642681131 ISBN-13(EAN): 9783642681134
Издательство: Springer
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Цена: 18167.00 р.
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Описание: The purpose of the present volume, the first of two on the pharmacology, biochemistry, and physiology of cyclic nucleotides, is to provide a comprehensive and up-to-date anthology on the nature and role of these important chemical regulators.

Автор: P. D. Kebabian; M. D. Nathanson
Название: Cyclic Nucleotides
ISBN: 3642683959 ISBN-13(EAN): 9783642683954
Издательство: Springer
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Описание: With contributions by numerous experts

Название: Cyclic Nucleotide Phosphodiesterases in Health and Disease
ISBN: 0367453320 ISBN-13(EAN): 9780367453329
Издательство: Taylor&Francis
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Since the last major compendium dedicated to cyclic nucleotide phosphodiesterases (PDEs) was published over 15 years ago, an enormous amount of progress has occurred in the field. There is great need for a centralized source for key information in this burgeoning and therapeutically important area of medical research.

Cyclic Nucleotide Phosphodiesterases in Health and Disease provides an integrated volume covering PDE biology from genes to organisms. It examines phosphodiesterases as pharmacological targets as well as the development of specific PDE inhibitors as therapeutic agents. With contributions from pioneers in the field, individual chapters describe one of the 11 known mammalian PDE families including the molecular characteristics, structure, function, and traits unique to each. Characteristics of PDEs from lower organisms are also the subject of other chapters since they provide key insights into PDE functions and are also pharmacological targets for treatment of a variety of diseases in humans and domestic animals. Chapters on the current biomedical and therapeutic research on PDEs include studies on gene-targeted knockout strategies and compartmentation in cyclic nucleotide signaling. By unraveling the unique cellular roles for different PDEs, scientists are beginning to open the door to the therapeutic use of PDE inhibitors for the treatment of a number of pathological conditions including asthma and inflammation, pulmonary hypertension, erectile dysfunction, and stroke.

By collating current information into a coherent and coordinated perspective, Cyclic Nucleotide Phosphodiesterases in Health and Disease provides an invaluable reference for industry and clinical scientists and points toward future directions of research and therapeutic advancements in developing selective inhibitors for these various enzymes.

Автор: Chou Shan-Ho, Guiliani Nicolas, Lee Vincent T.
Название: Microbial Cyclic Di-Nucleotide Signaling
ISBN: 3030333078 ISBN-13(EAN): 9783030333072
Издательство: Springer
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Описание:

Microbial Cyclic Di-Nucleotide Signaling

Chapter 21: Cyclic di-GMP signalingin extreme acidophilic bacteria (Castro Matнas, Dнaz Mauricio, Moy

Автор: L.B. Townsend
Название: Chemistry of Nucleosides and Nucleotides
ISBN: 1461282837 ISBN-13(EAN): 9781461282839
Издательство: Springer
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Цена: 16979.00 р.
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Описание: These volumes were designed with medicinal chemists, medicinal organic chemists, organic chemists, carbohydrate chemists, physical chemists, and biological chemists in mind.

Автор: L.B. Townsend
Название: Chemistry of Nucleosides and Nucleotides
ISBN: 0306436469 ISBN-13(EAN): 9780306436468
Издательство: Springer
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Описание: Five contributed chapters address mesionic nucleosides and heterobases; synthesis and properties of various disaccharide nucleosides; the synthesis, reactions, and properties of nucleoside mono-, di-, tri-, and tetraphosphates and nucleotides with changes in the phosphoryl residue; the synthesis and

Автор: L.B. Townsend
Название: Chemistry of Nucleosides and Nucleotides
ISBN: 1475796692 ISBN-13(EAN): 9781475796698
Издательство: Springer
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Автор: D.C. Baker; C.K. Chu
Название: Nucleosides and Nucleotides as Antitumor and Antiviral Agents
ISBN: 1461362210 ISBN-13(EAN): 9781461362210
Издательство: Springer
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Описание: More remarkably, the discovery of the chemotherapeutic agent AZT (Retrovir) was made within two years after the isolation and identification of the virus, followed by unprecedented drug development efforts to culminate in the FDA approval of AZT in twenty-three months, which was a record-breaking time for approval of any drug for a major disease.

Автор: Frederick De Serres
Название: Genetic Consequences of Nucleotide Pool Imbalance
ISBN: 1461294886 ISBN-13(EAN): 9781461294887
Издательство: Springer
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Описание: This book is concerned with the genetic consequences of nu- cleotide pool imbalance. This book grew out of a Conference on "Genetic Consequences of Nu- cleotide Pool Imbalance" which was held at the National Institute of Environmental Health Sciences on May 9-11, 1983.