Leukemia and Lymphoma: Molecular and Therapeutic Insights, Kharas Michael G., Levine Ross L., Melnick Ari M.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers our current understanding of the molecular underpinnings of leukemia and lymphoma, as well as recent progress in development of therapies that target them. The contributors review the
normal functions of hematopoietic stem cells--the precursors to white blood cells--and then examine the genetic, epigenetic, and cellular mechanisms that drive malignant transformation. The roles of clonal hematopoiesis, RNA-binding proteins, and alterations in metabolism and cell signaling (e.g.,
MAP kinase pathways) are among the topics covered in depth, along with the parts they play in specific types of leukemia and lymphoma.