How pathogenic microbes have been an intimate part of human history from the beginning--and how our deadliest germs and biggest pandemics are the product of our success as a species
Plagues upon the Earth is a monumental history of humans and their germs. Weaving together a grand narrative of global history with insights from cutting-edge genetics, Kyle Harper explains why humanity's uniquely dangerous disease pool is rooted deep in our evolutionary past, and why its growth is accelerated by technological progress. He shows that the story of disease is entangled with the history of slavery, colonialism, and capitalism, and reveals the enduring effects of historical plagues all around us, in patterns of wealth, health, power, and inequality. He also tells the story of humanity's escape from infectious disease--a triumph that makes life as we know it possible, yet destabilizes the environment and fosters new diseases. Panoramic in scope, Plagues upon the Earth traces role of disease in the transition to farming, the spread of cities, the advance of transportation, and the stupendous increase in human numbers. Harper offers a new interpretation of humanity's path to control over infectious disease--one where rising evolutionary threats constantly push back against human progress, and where the devastating effects of modernization contribute to the great divergence between societies. The book reminds us that human health is globally interdependent--and inseparable from the well-being of the planet itself. Putting the COVID-19 pandemic in perspective, Plagues upon the Earth tells the story of how we got here as a species, and it may help us decide where we want to go.
Описание: Lecture provides an overview of the progress made in molecular medicine applying genetics and genomics to the understanding, diagnosis, and treatment of human diseases. Specifically, the methods for identifying genes involved in human diseases are described. Examples from 10 genes and diseases will be provided, drawing on the author's research. Topics include examples from simple Mendelian diseases, such as cystic fibrosis, inherited cancers, oncogenes activated by chromosomal translocations, host genes involved in infectious disease, genes identified via genomewide association studies, pathogens causing cancer, and gene families contributing to multiple diseases. For each example, historical details will be provided as background for readers to understand the context and process of the discoveries, technologies explained, and current understanding and treatment implications detailed.
Автор: Dieter Haussinger, Verena Keitel, Ralf Kubitz Название: Hepatobiliary Transport in Health and Disease ISBN: 3110278995 ISBN-13(EAN): 9783110278996 Издательство: Walter de Gruyter Рейтинг: Цена: 29744.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The transport systems involved in hepatobiliary transport have been cloned and characterized at the molecular level and it is becoming clear that mutations and polymorphisms of individual transporter molecules underlie a variety of liver diseases.
Автор: Levine Название: The Protozoan Phylum Apicomplexa ISBN: 1315897008 ISBN-13(EAN): 9781315897004 Издательство: Taylor&Francis Рейтинг: Цена: 27562.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: About the turn of the century the Apicomplexa plus some other groups were called Sporozoa. With the advent of the electron microscope, it was realized that most "Sporozoa" have an apical complex; those which do not (the Microspora, Myxozoa, and Ascetospora) were removed and the name Apicomplexa was put forward by Dr. Levine in 1970.
Автор: Graham H. Coombs; Keith Vickerman; M.A. Sleigh; Al Название: Evolutionary Relationships Among Protozoa ISBN: 041279800X ISBN-13(EAN): 9780412798009 Издательство: Springer Рейтинг: Цена: 52827.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The evolutionary biology of protozoa is a field in which exciting changes are taking place. The various chapters are deliberately broad in scope and explore areas such as the contribution of different techniques and approaches to the understanding of protistan evolution and the biochemical and physiological aspects of that evolution;
Описание: Provides an overview of the progress made in molecular medicine applying genetics and genomics to the understanding, diagnosis, and treatment of human diseases. Specifically, the methods for identifying genes involved in human diseases are described. Examples from 10 genes and diseases are provided, drawing on the author`s research.
Автор: Pandey, Rajesh Название: Rna-Based Regulation In Human Health And Disease,16 ISBN: 0128171936 ISBN-13(EAN): 9780128171936 Издательство: Elsevier Science Рейтинг: Цена: 26444.00 р. Наличие на складе: Нет в наличии.
Описание:
RNA-based Regulation in Human Health and Disease offers an in-depth exploration of RNA mediated genome regulation at different hierarchies. Beginning with multitude of canonical and non-canonical RNA populations, especially noncoding RNA in human physiology and evolution, further sections examine the various classes of RNAs (from small to large noncoding and extracellular RNAs), functional categories of RNA regulation (RNA-binding proteins, alternative splicing, RNA editing, antisense transcripts and RNA G-quadruplexes), dynamic aspects of RNA regulation modulating physiological homeostasis (aging), role of RNA beyond humans, tools and technologies for RNA research (wet lab and computational) and future prospects for RNA-based diagnostics and therapeutics. One of the core strengths of the book includes spectrum of disease-specific chapters from experts in the field highlighting RNA-based regulation in metabolic & neurodegenerative disorders, cancer, inflammatory disease, viral and bacterial infections. We hope the book helps researchers, students and clinicians appreciate the role of RNA-based regulation in genome regulation, aiding the development of useful biomarkers for prognosis, diagnosis, and novel RNA-based therapeutics.
Автор: J. Winny Yun, J. Steven Alexander Название: The Lymphatic System in Health and Disease ISBN: 1615047913 ISBN-13(EAN): 9781615047918 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 5637.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The lymphatic system develops and functions in parallel with the blood circulatory system (termed the ""hemovasculature"") and accomplishes transport of interstitial fluids, dietary lipids, and reverse transport of cholesterol, immune cells, and antigens—providing a critical homeostatic fluid balance and transmission of immune cells and mediators back to the cardiovascular system. Although the daily flow of lymph (normally 1-2 L/day under unstressed conditions) is far lower than that of daily blood flow (which is 7,500 L/day), without the adequate functioning of the lymphatics, virtually all organs and tissues would acutely suffer many different physical and inflammatory stresses ranging from edema to organ system failure. Although blood and lymphatic vessels often form in anatomic parallels to one another, our knowledge of the workings of the lymphatic system, the fine structure of lymphatic networks, how they function in different organs, and how they are regulated physiologically and immunologically are far from parallel; our knowledge of the lymphatic system still remains at only a tiny fraction of what is understood about the cardiovascular system. Although both the cardiovascular and lymphatic systems are important transport systems, what they transport and how they transport and propel these very different cargoes could not be more dissimilar.This book provides an overview of the history of the discovery (and re-discovery) of the components of the lymphatic system, lymphatic anatomy, physiological functions of lymphatics, molecular features of the lymphatic system, and clinical perspectives involving lymphatics which may be of interest to scientists, clinicians, patients, and the lay public. We provide a current understanding of some of the more important structural similarities and differences between lymphatics and the blood vascular system, their coordinated control by angiogenic and hemangiogenic growth factors and other modulators, the fate and lineage determinants which control lymphatic development, and the roles that lymphatics may play in several different diseases.
Автор: J. Winny Yun, J. Steven Alexander Название: The Lymphatic System in Health and Disease ISBN: 161504793X ISBN-13(EAN): 9781615047932 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 8145.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The lymphatic system develops and functions in parallel with the blood circulatory system (termed the ""hemovasculature"") and accomplishes transport of interstitial fluids, dietary lipids, and reverse transport of cholesterol, immune cells, and antigens—providing a critical homeostatic fluid balance and transmission of immune cells and mediators back to the cardiovascular system. Although the daily flow of lymph (normally 1-2 L/day under unstressed conditions) is far lower than that of daily blood flow (which is 7,500 L/day), without the adequate functioning of the lymphatics, virtually all organs and tissues would acutely suffer many different physical and inflammatory stresses ranging from edema to organ system failure. Although blood and lymphatic vessels often form in anatomic parallels to one another, our knowledge of the workings of the lymphatic system, the fine structure of lymphatic networks, how they function in different organs, and how they are regulated physiologically and immunologically are far from parallel; our knowledge of the lymphatic system still remains at only a tiny fraction of what is understood about the cardiovascular system. Although both the cardiovascular and lymphatic systems are important transport systems, what they transport and how they transport and propel these very different cargoes could not be more dissimilar.This book provides an overview of the history of the discovery (and re-discovery) of the components of the lymphatic system, lymphatic anatomy, physiological functions of lymphatics, molecular features of the lymphatic system, and clinical perspectives involving lymphatics which may be of interest to scientists, clinicians, patients, and the lay public. We provide a current understanding of some of the more important structural similarities and differences between lymphatics and the blood vascular system, their coordinated control by angiogenic and hemangiogenic growth factors and other modulators, the fate and lineage determinants which control lymphatic development, and the roles that lymphatics may play in several different diseases.
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