Описание: Diet and Lifestyle in Prostate Cancer.- Dietary Carcinogens and DNA Adducts in Prostate Cancer.-Genetic, Environmental, and Nuclear Factors Governing Genomic.- Cells of Origin for Prostate Cancer.- Prostate Cancer Genomic Subtypes.- Prostate Cancer Transcriptomic Subtypes.- Immunological complexity of the prostate cancer microenvironment influences the response to immunotherapy.- The Tumor Microenvironments of Lethal Prostate Cancer.- The Bone Microenvironment in Prostate Cancer Metastasis.- Prostate Cancer Energetics and Biosynthesis.- Canonical and Noncanonical Androgen Metabolism and Activity.- Germline and Somatic Defects in DNA Repair Pathways in Prostate Cancer.- The Role of RB in Prostate Cancer Progression.- Interplay among PI3K/AKT, PTEN/FOXO and AR signaling in prostate cancer.- Androgen Receptor Dependence.- WNT/BETA-CATENIN SIGNALING AND PROSTATE CANCER THERAPY RESISTANCE.- Epigenetic Regulation of Chromatin in Prostate Cancer.- Oncogenic ETS factors in prostate cancer.- Neural Transcription Factors in Disease Progression.- Index.
Описание: The tumor microenvironment has become a very important and hot topic in cancer research within the past few years. The tumor microenvironment is defined as the normal cells, molecules, and blood vessels that surround and feed a tumor cell. As many scientists have realized, studying the tumor microenvironment has become critical to moving the field forward, since there are many players in a tumor’s localized and surrounding area, which can significantly change cancer cell behavior. There is a dual relationship wherein the tumor can change its microenvironment and the microenvironment can affect how a tumor grows and spreads. Tumor Microenvironment in Cancer Progression and Cancer Therapy aims to shed light on the mechanisms, factors, and mediators that are involved in the cancer cell environment. Recent studies have demonstrated that in addition to promoting tumor progression and protecting tumor cells from the spontaneous immune-mediated rejection and different forms of cancer therapeutics, tumor microenvironment can also be a target and mediator of both standard and newly-emerging forms of cancer therapeutics. Thus, the dual role of the tumor microenvironment is the integral focus of the volume. The volume highlights the bi-directional interactions between tumor cells and non-malignant tumor component during tumor progression and treatment. It also focuses on the three groups of the reactive tumor component: stromal cells, blood vessels and the infiltrating immune cells. These three groups are discussed under the lens of their role in promoting tumor growth, shielding the tumor from rejection and from standard forms of cancer therapies. They are emerging as targets and mediators of standard and new forms of potential therapy.
Описание: This book reviews biochemistry, molecular biology and genetic changes in prostate cells that are the driving forces in the initiation and progression of cancer. Surveys cell interactions, including stem cells, reactive Stromal cells and membrane lipid rafts.
Описание: Recent studies have demonstrated that in addition to promoting tumor progression and protecting tumor cells from the spontaneous immune-mediated rejection and different forms of cancer therapeutics, tumor microenvironment can also be a target and mediator of both standard and newly-emerging forms of cancer therapeutics.
Автор: Shree Ram Singh; Pranela Rameshwar Название: MicroRNA in Development and in the Progression of Cancer ISBN: 1493944916 ISBN-13(EAN): 9781493944910 Издательство: Springer Рейтинг: Цена: 19589.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Altered expression of particular miRNAs has been implicated in the onset and development of cancer and could be used as potential biomarkers for the disease.Recently, many studies have found miRNAs have crucial regulatory roles in Cancer stem cells (CSCs) a kind of tumor initiating cells (TICs) and dormancy.
Автор: Singh Shree Ram Название: MicroRNA in Development and in the Progression of Cancer ISBN: 1489980644 ISBN-13(EAN): 9781489980649 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: miRNAs are a class of endogenous, small non-protein coding RNA molecules (~ 22 nucleotides) which are novel post-transcriptional regulators of gene expression. Since we have hundreds of miRNAs, the major challenge is now to understand their specific biological function. In fact the experimental evidence suggests that signaling pathways could be ideal candidates for miRNA-mediated regulation. Several studies suggest that miRNAs affect the responsiveness of cells to signaling molecules such as WNT, Notch, TGF-? and EGFR. Altered expression of particular miRNAs has been implicated in the onset and development of cancer and could be used as potential biomarkers for the disease. Recently, many studies have found miRNAs have crucial regulatory roles in Cancer stem cells (CSCs) a kind of tumor initiating cells (TICs) and dormancy. Findings also suggest that DNA methylation may be important in regulating the expression of many miRNAs in several cancer initiating cells. Several miRNAs are known to either upregulated or downregulated in CSCs when compared to non-cancerous cells from the same tissues. CSCs are a small subpopulation of cells identified in a variety of tumors and involve in self-renewal, differentiation, chemoresistance and tumorigenesis. The volume will give a comprehensive account of important advancements in the area of miRNAs and cancer.
Описание: The processes of tumor metastasis, apoptosis and anti-tumor immune response are among the most complex yet rapidly advancing fields in the area of cancer research. This monograph, with its leading authorship, presents a comprehensive coverage of the recent advances in the various key concepts in these fundamental aspects of human cancer.
Описание: Get a quick, expert overview of the many key facets of lung cancer evaluation and management with this concise, practical resource by Drs. Lynn T. Tanoue and Frank Detterbeck. This easy-to-read reference presents a summary of today`s best evidence-based approaches to diagnosis and management in this critical area.
An Evidence-Based Approach to the Management of Nasopharyngeal Cancer: From Basic Science to Clinical Presentation and Treatment provides a comprehensive overview with updated management procedures for nasopharyngeal carcinoma. Written by experts on the subject, it is organized in a simple yet comprehensive manner to aid in the understanding of this complex condition. The book discusses several topics related to NPC, including epidemiology, pathophysiology, risk factors and treatment (surgical and non-surgical). Additionally, it discusses key features of clinical presentation of NPC, recent advances and promising new therapies.
This will be a valuable source for clinicians, graduate students, oncologists and several members of the biomedical field who are interested in understanding nasopharyngeal cancer in a practical and applicable way.
Автор: American Cancer Society, Elk Ronit, Landrine Hope Название: Cancer Disparities: Causes and Evidence-Based Solutions ISBN: 0826108822 ISBN-13(EAN): 9780826108821 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 11161.00 р. Наличие на складе: Нет в наличии.
Описание:
The volume sheds new light on reducing disparities by complementing currently available monographs, through the provision of solutions that are not only theoretically innovative but also empirically effective. Indeed, Cancer Disparities: Causes and Evidence-Based Solutions admirably achieves two key objectives that are crucial for advances in the field: (a) providing an up-to-date overview of cancer-related disparities and (b) describing evidence-based interventional approaches to close the cancer-related disparities gap. The implicit promise is that these approaches will enable public health practitioners, cancer control workers, and community members to use or adapt them in their own communities. This volume is essential to help make that promise a reality.--PsycCRITIQUES
Cancer is not randomly distributed in the United States. Its incidence varies by race, ethnicity, socioeconomic status, and other geographic and demographic factors. This volume, co-published with the American Cancer Society, is the first to examine the biological, racial, and socioeconomic factors that influence cancer incidence and survival. In addition, it presents 15 previously unpublished, evidence-based interventions to reduce and eliminate cancer disparities.
The book explains the nature, scope, and causes of cancer disparities across different populations and then presents unique programs proven to reduce such inequalities in the areas of cancer prevention, screening and early detection, treatment, and survivorship. They represent a variety of cancers, populations, and communities across the U.S. Descriptions of each intervention include tests of effectiveness and are written in sufficient detail for readers to replicate them within their own communities.
Key Features:
Offers an in-depth look at the latest research behind cancer disparities
Written by highly respected and published cancer researchers
Includes 15 never-before published, evidence-based interventions that readers can replicate
Discusses breast, colorectal, cervical, and other pernicious cancers
Includes interventions for African-American, Hispanic, Native American, and other populations
Автор: Charlie Changli Xue, Chuanjian Lu, Brian H May Название: Evidence-based Clinical Chinese Medicine: Volume 18: Cancer Pain ISBN: 981123793X ISBN-13(EAN): 9789811237935 Издательство: World Scientific Publishing Рейтинг: Цена: 27956.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This eighteenth volume of the Evidence-based Clinical Chinese Medicine series aims to provide a multi-faceted "whole evidence" analysis of the management of pain due to a range of cancers (cancer pain) using integrative Chinese medicine.
Описание: This book presents the research evidence relevant to the application of a range of commonly used non-pharmacological interventions in supportive cancer care, including massage, acupressure, Qigong, yoga, mind-body therapy, and mindfulness-based intervention.
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