Sigma Proteins: Evolution of the Concept of Sigma Receptors, Felix J. Kim; Gavril W. Pasternak

Автор: Felix J. Kim; Gavril W. Pasternak
Название: Sigma Proteins: Evolution of the Concept of Sigma Receptors
ISBN: 3319658514 ISBN-13(EAN): 9783319658513
Издательство: Springer
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Цена: 39130.00 р.
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Описание: Two sigma receptor subtypes have been proposed, sigma1 and 2. Largely based on traditional pharmacologic approaches, the Sigma1 protein has been associated with a broad range of signaling systems, including G-protein coupled receptors, NMDA receptors, and ion channels.

Автор: Gary J. Kelloff; Ernest T. Hawk; Caroline C. Sigma
Название: Cancer Chemoprevention
ISBN: 1627038175 ISBN-13(EAN): 9781627038171
Издательство: Springer
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Цена: 39130.00 р.
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Описание: Despite significant advances in cancer treatment and measures of neoplastic progression, drug effect (or early detection, overall cancer incidence has increased, pharmacodynamic markers), and markers that measure cancer-associated morbidity is considerable, and overall prognosis as well as predict responses to specific therapy. cancer survival has remained relatively flat over the past All these biomarkers have the potential to greatly augment several decades (1,2). However, new technology the development of successful chemoprevention therapies, allowing exploration of signal transduction pathways, but two specific types of biomarkers will have the most identification of cancer-associated genes, and imaging of immediate impact on successful chemopreventive drug tissue architecture and molecular and cellular function is development—those that measure the risk of developing increasing our understanding of carcinogenesis and cancer invasive life-threatening disease, and those whose mo- progression. This knowledge is moving the focus of cancer lation can “reasonably predict” clinical benefit and, therapeutics, including cancer preventive treatments, to therefore, serve as surrogate endpoints for later-occurring drugs that take advantage of cellular control mechanisms clinical disease. Thus far, the biomarker that best measures to selectively suppress cancer progression. these two phenomena is intraepithelial neoplasia (IEN) Carcinogenesis is now visualized as a multifocal, because it is a near obligate precursor to cancer.

Автор: Rae R. Matsumoto; Wayne D. Bowen; Tsung Ping Su
Название: Sigma Receptors
ISBN: 1489988688 ISBN-13(EAN): 9781489988683
Издательство: Springer
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Цена: 30745.00 р.
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Описание: Over the last 30 years, our understanding of a receptors has undergone a colossal evolution. They began as theoretical entities, then progressed to enigmatic receptors, and finally to identified proteins with important biological functions. Since the first book on a receptors was published in 1994, there have been many significant advances in the field. We now know that o receptors subserve many critical functions in the body and recent studies indicate that they are promising drug development targets for a host of neurological, psychiatric, cardiovascular, ophthalmological, immunological, and gastrointestinal disorders. This book provides a timely update on the medicinal chemistry, cell biology, and clinical implications of a receptors. It puts the information in a historical perspective to help new comers to the field successfully navigate the confusing early history surrounding these proteins, and it provides a launching point from which future studies and research directions can easily be developed. The full impact of a receptors on biological function has yet to be determined. The existing gaps in our knowledge base offer untold opportunities for future research. It is our hope that the information contained in this book will stimulate new, exciting research on a receptors and ultimately lead to innovative insights into basic biological mechanisms and novel therapeutic advances.

Автор: Gary J. Kelloff; Ernest T. Hawk; Caroline C. Sigma
Название: Cancer Chemoprevention
ISBN: 1617373427 ISBN-13(EAN): 9781617373428
Издательство: Springer
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Цена: 45979.00 р.
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