Behavioral Neuroscience of Orexin/Hypocretin, Andrew J Lawrence; Luis de Lecea

Автор: Takeshi Sakurai; S.R. Pandi-Perumal; Jaime M. Mont
Название: Orexin and Sleep
ISBN: 3319352202 ISBN-13(EAN): 9783319352206
Издательство: Springer
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Цена: 16977.00 р.
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Описание: This volume is intended for neuropharmacologists, psychopharmacologists, pharmacologists, pharmacists, sleep researchers, translational neuroscience researchers, and other basic researchers and clinical scientists interested in an interdisciplinary approach to sleep medicine.

Автор: Andrew J Lawrence; Luis de Lecea
Название: Behavioral Neuroscience of Orexin/Hypocretin
ISBN: 3319575341 ISBN-13(EAN): 9783319575346
Издательство: Springer
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Цена: 23757.00 р.
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Описание: This issue of Current Topics in Behavioral Neuroscience focuses on the neuropeptide orexin (hypocretin) and brings together scientists from around the world who will provide a timely discussion of how this peptide regulates behavior.

Автор: Luis De Lecea; J. Gregor Sutcliffe
Название: Hypocretins
ISBN: 1461498066 ISBN-13(EAN): 9781461498063
Издательство: Springer
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Цена: 20962.00 р.
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Описание: The first report that rapid eye movements occur in sleep in humans was published in 1953. The research journey from this point to the realization that sleep consists of two entirely independent states of being (eventually labeled REM sleep and non-REM sleep) was convoluted, but by 1960 the fundamental duality of sleep was well established including the description of REM sleep in cats associated with "wide awake" EEG patterns and EMG suppression. The first report linking REM sleep to a pathology occurred in 1961 and a clear association of sleep onset REM periods, cataplexy, hypnagogic hallucinations and sleep paralysis was fully established by 1966. When a naive individual happens to observe a full-blown cataplexy attack, it is both dramatic and unnerving. Usually the observer assumes that the loss of muscle tone represents syncope or seizure. In order to educate health professionals and the general public, Christian Guilleminault and I made movies of full-blown cataplectic episodes (not an easy task). We showed these movies of cataplexy attacks to a number of professional audiences, and were eventually rewarded with the report of a similar abrupt loss of muscle tone in a dog. We were able to bring the dog to Stanford University and with this as the trigger, we were able to develop the Stanford Canine Narcolepsy Colony. Breeding studies revealed the genetic determinants of canine narcolepsy, an autosomal recessive gene we termed canarc1. Emmanuel Mignot took over the colony in 1986 and began sequencing DNA, finally isolating canarc1 in 1999.

Автор: Takeshi Sakurai; S.R. Pandi-Perumal; Jaime M. Mont
Название: Orexin and Sleep
ISBN: 3319230778 ISBN-13(EAN): 9783319230771
Издательство: Springer
Рейтинг:
Цена: 22359.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: This volume is intended for neuropharmacologists, psychopharmacologists, pharmacologists, pharmacists, sleep researchers, translational neuroscience researchers, and other basic researchers and clinical scientists interested in an interdisciplinary approach to sleep medicine. The level of the book is aiming at CNS researchers, drug development scientists, basic and clinical sleep researchers, as well as senior medical students and fellows in psychiatry and neurology. Orexin and Sleep provides a unique resource, giving a comprehensive and highly readable summary of the basic concepts in orexin biology and pharmacology along with clinical applications in sleep medicine in general, and narcolepsy in particular.