Описание: Recent trends in health care across the United States and internationally have emphasized a novel approach that consists in comparing the effectiveness and efficacy of treatment interventions with a patient-centered emphasis (i.e., evidence-based health care), while ensuring cost constraints, maximizing benefits, and minimizing risks. In this book, experts in comparative effectiveness and efficacy research and analysis for practice (CEERAP) in health care in general address a range of topical issues. The emphasis is on implications for endodontics and nursing, both of which are considered in a series of detailed chapters. Commonalities and differences among CEERAP, utility-based and logic-based analysis and decision-making, and evidence-based and patient-centered practice are defined and discussed. The book concludes by examining applications for CEERAP in developing patient-centered optimal treatment interventions for the next decade.
Автор: Mallinckrodt, Craig Molenberghs, Geert Lipkovich, Ilya (quintiles, Durham, North Carolina, Usa) Ratitch, Bohdana (eli Lilly Cananda, Ontario, Canada) Название: Estimands, estimators and sensitivity analysis in clinical trials ISBN: 1138592501 ISBN-13(EAN): 9781138592506 Издательство: Taylor&Francis Рейтинг: Цена: 17609.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book will use the new guidance as a framework for developing and implementing comprehensive analysis plans for clinical trials that support the development and approval of medical interventions.
Описание: Upgraded to reflect the latest research and software applications on the topic, this new edition continues to provide a comprehensive introduction to the statistical methods for analyzing survival data.
Автор: Aidan G. C. Wright, Michael N. Hallquist Название: The Cambridge Handbook of Research Methods in Clinical Psychology ISBN: 1316639525 ISBN-13(EAN): 9781316639528 Издательство: Cambridge Academ Рейтинг: Цена: 9662.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This Handbook provides an overview and guide for state-of-the-art research methods in clinical psychological science. It is the ideal resource for clinical psychologists, graduate students studying clinical psychology, and practitioners or researchers in allied disciplines including psychiatry and social work.
Автор: Ton J. Cleophas; Aeilko H. Zwinderman Название: Efficacy Analysis in Clinical Trials an Update ISBN: 3030199177 ISBN-13(EAN): 9783030199173 Издательство: Springer Рейтинг: Цена: 9781.00 р. Наличие на складе: Поставка под заказ.
Описание: Machine learning and big data is hot. It is, however, virtually unused in clinical trials. This is so, because randomization is applied to even out multiple variablesModern medical computer files often involve hundreds of variables like genes and other laboratory values, and computationally intensive methods are requiredThis is the first publication of clinical trials that have been systematically analyzed with machine learning. In addition, all of the machine learning analyses were tested against traditional analyses. Step by step statistics for self-assessments are includedThe authors conclude, that machine learning is often more informative, and provides better sensitivities of testing than traditional analytic methods do
Описание: In this book, leading international experts analyze state-of-the-art advances in gene transfer vectors for applications in inherited disorders and also examine the toxicity profiles of these methods.
Описание: In this book, leading international experts analyze state-of-the-art advances in gene transfer vectors for applications in inherited disorders and also examine the toxicity profiles of these methods.
Using time-to-event analysis methodology requires careful definition of the event, censored observation, provision of adequate follow-up, number of events, and independence or noninformativeness of the censoring mechanisms relative to the event. Design and Analysis of Clinical Trials with Time-to-Event Endpoints provides a thorough presentation of the design, monitoring, analysis, and interpretation of clinical trials in which time-to-event is of critical interest.
After reviewing time-to-event endpoint methodology, clinical trial issues, and the design and monitoring of clinical trials, the book focuses on inferential analysis methods, including parametric, semiparametric, categorical, and Bayesian methods; an alternative to the Cox model for small samples; and estimation and testing for change in hazard. It then presents descriptive and graphical methods useful in the analysis of time-to-event endpoints. The next several chapters explore a variety of clinical trials, from analgesic, antibiotic, and antiviral trials to cardiovascular and cancer prevention, prostate cancer, astrocytoma brain tumor, and chronic myelogonous leukemia trials. The book then covers areas of drug development, medical practice, and safety assessment. It concludes with the design and analysis of clinical trials of animals required by the FDA for new drug applications.
Drawing on the expert contributors' experiences working in biomedical research and clinical drug development, this comprehensive resource covers an array of time-to-event methods and explores an assortment of real-world applications.
Описание: This book provides statisticians with an understanding of the critical challenges currently encountered in oncology trials. The book covers state-of-the-art approaches to the design and analysis of cancer clinical trials, such as adaptive designs, biomarker-based trials, and dynamic treatment regimes.
Описание: In medical and health care the scientific method is little used, and statistical software programs are experienced as black box programs producing lots of p-values, but little answers to scientific questions. The pocket calculator analyses appears to be, particularly, appreciated, because they enable medical and health professionals and students for the first time to understand the scientific methods of statistical reasoning and hypothesis testing. So much so, that it can start something like a new dimension in their professional world. In addition, a number of statistical methods like power calculations and required sample size calculations can be performed more easily on a pocket calculator, than using a software program. Also, there are some specific advantages of the pocket calculator method. You better understand what you are doing. The pocket calculator works faster, because far less steps have to be taken, averages can be used. The current nonmathematical book is complementary to the nonmathematical "SPSS for Starters and 2nd Levelers" (Springer Heidelberg Germany 2015, from the same authors), and can very well be used as its daily companion.
Автор: Dias Название: Network Meta-Analysis for Decision Making ISBN: 1118647505 ISBN-13(EAN): 9781118647509 Издательство: Wiley Рейтинг: Цена: 9496.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A practical guide to network meta-analysis with examples and code In the evaluation of healthcare, rigorous methods of quantitative assessment are necessary to establish which interventions are effective and cost-effective.
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