Enzyme kinetics and mechanism, Cook, Paul F. (university Of Oklahoma, Usa) Cleland, W. W. (university Of Wisconsin-madison, Usa)

Автор: Voth, Gregory
Название: Computational Approaches for Studying Enzyme Mechanism,577
ISBN: 012805347X ISBN-13(EAN): 9780128053478
Издательство: Elsevier Science
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Computational Approaches for Studying Enzyme Mechanism Part A, is the first of two volumes in the Methods in Enzymology series, focusses on computational approaches for studying enzyme mechanism.

Автор: Daniel L. Purich
Название: Enzyme Kinetics and Mechanism, Part F: Detection and Characteriza
ISBN: 0121822575 ISBN-13(EAN): 9780121822576
Издательство: Elsevier Science
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Описание: The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with mo than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

Автор: Voth, Gregory
Название: Computational Approaches for Studying Enzyme Mechanism Part B,578
ISBN: 0128111070 ISBN-13(EAN): 9780128111079
Издательство: Elsevier Science
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Computational Approaches for Studying Enzyme Mechanism, Part B is the first of two volumes in the Methods in Enzymology series that focuses on computational approaches for studying enzyme mechanism. The serial achieves the critically acclaimed gold standard of laboratory practices and remains one of the most highly respected publications in the molecular biosciences.

Название: Enzyme kinetics in drug metabolism
ISBN: 1627037578 ISBN-13(EAN): 9781627037570
Издательство: Springer
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Описание:

1. Enzyme Kinetics in Drug Metabolism - Fundamentals and Applications

Swati Nagar, Upendra A. Argikar, and Donald J. Tweedie

Part I. Fundamentals of Enzyme Kinetics

2. Fundaments of Enzyme Kinetics

Eleanore Seibert and Timothy S. Tracy

3. Different Enzyme Kinetic Models

Eleanore Seibert and Timothy S. Tracy

4. Reversible Mechanisms of Enzyme Inhibitors and Resulting Clinical Significance

Barbara Ring, Steven A. Wrighton, and Michael Mohutsky

5. Irreversible Enzyme Inhibition Kinetics and Drug-Drug Interactions

Michael Mohutsky and Stephen D. Hall

6. Multi-Enzyme Kinetics and Sequential Metabolism

Larry C. Wienkers and Brooke VandenBrink

7. Consideration of the Unbound Drug Concentration in Enzyme Kinetics

Nigel J. Waters, R. Scott Obach, and Li Di

Part II. Kinetics of Drug Metabolizing Enzymes and Transporters

8. Enzyme Kinetics of Oxidative Metabolism - Cytochromes P450

Ken Korzekwa

9. Enzyme Kinetics, Pharmacokinetics, Inhibition, and Regioselectivity of Aldehyde Oxidase

John T. Barr, Kanika Choughule, and Jeffrey P. Jones

10. Enzyme Kinetics of Conjugative Enzymes - PAPS

Margaret O. James

11. Enzyme Kinetics of Uridine Diphosphate Glucuronosyltransferases (UGTs)

Jin Zhou and John Miners

12. Principles and Experimental Considerations for in vitro Transporter Interaction Assays

Sid Bhoopathy, Chris Bode, Vatsala Naageshwaran, Erica A. Wiskercher, and Ismael J. Hidalgo

Part III. Modeling Considerations

13. Rationalising Under-Prediction of Drug Clearance from Enzyme and Transporter Kinetic Data - from in vitro Tools to Mechanistic Modeling

Aleksandra Galetin

14. The Structural Model for the Mass Action Kinetic Analysis of P-gp Mediated Transport Through Confluent Cell Monolayers

Joseph Bentz and Harma Ellens

15. Systems Biology Approaches to Enzyme Kinetics: Analyzing Network Models of Drug Metabolism

Nnena A. Finn and Melissa L. Kemp

Part IV. Variability in Kinetics

16. Variability in Human in vitro Enzyme Kinetics

Ying-Hong Wang and Christopher R. Gibson

17. Sources of Interindividual Variability

Yvonne Lin and Kenneth E. Thummel

Part V. Case Studies

18. Case Study 1. Practical Considerations with Experimental Design and Interpretation

John T. Barr, Darcy R. Flora, and Otito Iwuchukwu

19. Case Study 2. Practical Analytical Considerations for Conducting in vitro Enzyme Kinetic Studies

Upendra A. Argikar and Swati Nagar

20. Case Study 3. Application of Basic Enzyme Kinetics to Metabolism Studies - Real Life Examples

Yongmei Li, Michelle McCabe, Lalitha Podila, Timothy S. Tracy, and Donald J. Tweedie

21. Case Study 4. Predicting the Drug Interaction Potential for Inhibition of CYP2C8 by Montelukast

Ken Korzekwa

22. Case Study 5. Deconvoluting Hyperbilirubinemia: Differentiating Between Hepatotoxicity and Reversible Inhibition of UGT1A, MRP2 or OATP1B1 in Drug Development

Ian Templeton, Gary Eichenbaum, Rucha Sane, and Jin Zhou

23. Case Study 6. Drug Transporters: in vitro Solutions for Translatable Outcomes

Sid Bhoopathy, Chris Bode, Vatsala Naageshwaran, Erica A. Weiskircher, and Ismael J. Hidalgo

24. Case Study 7. Compiled Aha Moments in Enzyme Kine

Автор: Antonio Baici
Название: Kinetics of Enzyme-Modifier Interactions
ISBN: 3709114012 ISBN-13(EAN): 9783709114018
Издательство: Springer
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Описание: The kinetic mechanisms by which enzymes interact with inhibitors and activators, collectively called modifiers, are scrutinized and ranked taxonomically into autonomous species in a way similar to that used in the biological classification of plants and animals. The systematization of the mechanisms is based on two fundamental characters: the allosteric linkage between substrate and modifier and the factor by which a modifier affects the catalytic constant of the enzyme. Combinations of the physically significant states of these two characters in an ancestor-descendant-like fashion reveal the existence of seventeen modes of interaction that cover the needs of total, partial and fine-tuning modulation of enzyme activity. These interactions comprise five linear and five hyperbolic inhibition mechanisms, five nonessential activation mechanisms and two hybrid species that manifest either hyperbolic inhibition or nonessential activation characteristics depending on substrate concentration. Five essential activation mechanisms, which are taxonomically independent of the mentioned basic species, complete the inventory of enzyme modifiers. Often masked under conventional umbrella terms or treated as anomalous cases, all seventeen basic inhibition and nonessential activation mechanisms are represented in the biochemical and pharmacological literature of this and the past century, either in the form of rapid or slow-onset reversible interactions, or as irreversible modification processes. The full potential of enzyme inhibitors and activators can only be appreciated after elucidating the details of their kinetic mechanisms of action exploring the entire range of physiologically significant reactant concentrations. This book highlights the wide spectrum of allosteric enzyme modification in physiological occurrences as well as in pharmacological and biotechnological applications that embrace simple and multiple enzyme-modifier interactions. The reader is guided in the journey through this still partly uncharted territory with the aid of mechanistically-oriented criteria aimed at showing the logical way towards the identification of a particular mechanism.

Автор: Swati Nagar; Upendra A. Argikar; Donald J. Tweedie
Название: Enzyme Kinetics in Drug Metabolism
ISBN: 1493960466 ISBN-13(EAN): 9781493960460
Издательство: Springer
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Цена: 21661.00 р.
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Описание:

1. Enzyme Kinetics in Drug Metabolism - Fundamentals and Applications

Swati Nagar, Upendra A. Argikar, and Donald J. Tweedie

Part I. Fundamentals of Enzyme Kinetics

2. Fundaments of Enzyme Kinetics

Eleanore Seibert and Timothy S. Tracy

3. Different Enzyme Kinetic Models

Eleanore Seibert and Timothy S. Tracy

4. Reversible Mechanisms of Enzyme Inhibitors and Resulting Clinical Significance

Barbara Ring, Steven A. Wrighton, and Michael Mohutsky

5. Irreversible Enzyme Inhibition Kinetics and Drug-Drug Interactions

Michael Mohutsky and Stephen D. Hall

6. Multi-Enzyme Kinetics and Sequential Metabolism

Larry C. Wienkers and Brooke VandenBrink

7. Consideration of the Unbound Drug Concentration in Enzyme Kinetics

Nigel J. Waters, R. Scott Obach, and Li Di

Part II. Kinetics of Drug Metabolizing Enzymes and Transporters

8. Enzyme Kinetics of Oxidative Metabolism - Cytochromes P450

Ken Korzekwa

9. Enzyme Kinetics, Pharmacokinetics, Inhibition, and Regioselectivity of Aldehyde Oxidase

John T. Barr, Kanika Choughule, and Jeffrey P. Jones

10. Enzyme Kinetics of Conjugative Enzymes - PAPS

Margaret O. James

11. Enzyme Kinetics of Uridine Diphosphate Glucuronosyltransferases (UGTs)

Jin Zhou and John Miners

12. Principles and Experimental Considerations for in vitro Transporter Interaction Assays

Sid Bhoopathy, Chris Bode, Vatsala Naageshwaran, Erica A. Wiskercher, and Ismael J. Hidalgo

Part III. Modeling Considerations

13. Rationalising Under-Prediction of Drug Clearance from Enzyme and Transporter Kinetic Data - from in vitro Tools to Mechanistic Modeling

Aleksandra Galetin

14. The Structural Model for the Mass Action Kinetic Analysis of P-gp Mediated Transport Through Confluent Cell Monolayers

Joseph Bentz and Harma Ellens

15. Systems Biology Approaches to Enzyme Kinetics: Analyzing Network Models of Drug Metabolism

Nnena A. Finn and Melissa L. Kemp

Part IV. Variability in Kinetics

16. Variability in Human in vitro Enzyme Kinetics

Ying-Hong Wang and Christopher R. Gibson

17. Sources of Interindividual Variability

Yvonne Lin and Kenneth E. Thummel

Part V. Case Studies

18. Case Study 1. Practical Considerations with Experimental Design and Interpretation

John T. Barr, Darcy R. Flora, and Otito Iwuchukwu

19. Case Study 2. Practical Analytical Considerations for Conducting in vitro Enzyme Kinetic Studies

Upendra A. Argikar and Swati Nagar

20. Case Study 3. Application of Basic Enzyme Kinetics to Metabolism Studies - Real Life Examples

Yongmei Li, Michelle McCabe, Lalitha Podila, Timothy S. Tracy, and Donald J. Tweedie

21. Case Study 4. Predicting the Drug Interaction Potential for Inhibition of CYP2C8 by Montelukast

Ken Korzekwa

22. Case Study 5. Deconvoluting Hyperbilirubinemia: Differentiating Between Hepatotoxicity and Reversible Inhibition of UGT1A, MRP2 or OATP1B1 in Drug Development

Ian Templeton, Gary Eichenbaum, Rucha Sane, and Jin Zhou

23. Case Study 6. Drug Transporters: in vitro Solutions for Translatable Outcomes

Sid Bhoopathy, Chris Bode, Vatsala Naageshwaran, Erica A. Weiskircher, and Ismael J. Hidalgo

24. Case Study 7. Compiled Aha Moments in Enzyme Kine

Автор: Paul C. Engel
Название: Enzyme Kinetics
ISBN: 0412239701 ISBN-13(EAN): 9780412239700
Издательство: Springer
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Описание: The student of biological science in his final years as an undergraduate and his first years as a graduate is expected to gain some familiarity with current research at the fron tiers of his discipline.

Автор: H. J. Fromm
Название: Initial Rate Enzyme Kinetics
ISBN: 3642809685 ISBN-13(EAN): 9783642809682
Издательство: Springer
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Цена: 18167.00 р.
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Описание: Enzyme kinetics has undergone very rapid growth and development during the past fifteen years and has been well received by the biochemical community.

Автор: Kenneth B. Taylor
Название: Enzyme Kinetics and Mechanisms
ISBN: 9048160650 ISBN-13(EAN): 9789048160655
Издательство: Springer
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Цена: 23508.00 р.
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Описание: The logic relating the chemical models to the mathematical models and the logic of relating the mathematical models to data is presented in rather concise text, figures and equations.