Название: Modern cns drug discovery ISBN: 3031619919 ISBN-13(EAN): 9783031619915 Издательство: Springer Цена: 11179.00 р. Наличие на складе: Есть у поставщикаПоставка под заказ. Описание: This new edition is a comprehensive guide to the intricate world of drug discovery and development. It provides readers with an update on basic and novel concepts, approaches and technologies that are used in the discovery and development of new therapeutics for diseases of the central nervous system (CNS). A major aim is to support the education of professionals and specialists in the biomedical neurosciences that will become the innovators, entrepreneurs, and leaders of the future. The educational focus is now enhanced by the inclusion of over 150 study questions available in the free Springer Nature Flashcard App, which makes this a unique book in its field. Divided into five sections, the book starts by introducing concepts and ideas to inspire the next generation of life scientists pursuing careers in drug discovery for CNS diseases. In the following section, key strategies and methods for identifying and testing novel drug targets are described. New chapters on important topics have been added, that is, the blood brain barrier, mass spectrometry, biased signaling and the exposome. The third section highlights strategies and technologies in translational CNS drug discovery and looks at safety and drug metabolism assessment, imaging techniques and functional testing to investigate drug treatment outcomes. The chapters in the fourth section address the emergence of transdiagnostic approaches as exemplified by the Research Domain Criteria initiative and non-invasive brain stimulation techniques. Finally, the book concludes with the late stages of drug development, such as the planning and performance of clinical trials, and regulatory approval. Written by experts from academia and industry, the book covers important fundamentals and best practices as well as current developments in neurotherapeutic research. It offers in-depth insights into the world of drug development and is essential reading for young scientists who are interested in translational research and want to prepare for an academic or industry career in CNS drug discovery.
Описание: Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant and most challenging areas of drug discovery.
Автор: Schreiber Название: Modern CNS Drug Discovery ISBN: 303062353X ISBN-13(EAN): 9783030623531 Издательство: Springer Рейтинг: Цена: 7685.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This textbook provides a comprehensive overview of the currently used concepts, approaches and technologies in the discovery and development of new treatments for the full spectrum of disorders of the central nervous system.
Автор: McArthur, Robert A. Название: Translational Neuroimaging ISBN: 0123869455 ISBN-13(EAN): 9780123869456 Издательство: Elsevier Science Рейтинг: Цена: 22233.00 р. Наличие на складе: Поставка под заказ.
Описание: Examines the translational role of neuroimaging in model development from preclinical animal models, to human experimental medicine, and finally to clinical studies. This book provides common endpoints between species that can serve to inform the clinic and bench with the information needed to accelerate clinically-effective CNS drug discovery.
Описание: Suitable for researchers in academia and pharmaceutical industry who use animal models in research and development of drugs for neurological disorders, this title identifies and provides common endpoints between species that can serve to inform the clinic and the bench with information needed to accelerate clinically-effective CNS drug discovery.
Описание: Suitable for researchers in academia and pharmaceutical industry who use animal models in research and development of drugs for psychiatric disorders, this title identifies and provides common endpoints between species that can serve to inform the clinic and the bench with information needed to accelerate clinically-effective CNS drug discovery.
Описание: Suitable for researchers in academia and pharmaceutical industry who use animal models in research and development of drugs for reward deficit disorders, this title identifies and provides common endpoints between species that can serve to inform the clinic and bench with information needed to accelerate clinically-effective CNS drug discovery.
Описание: Offers a review of what we know about neural networks. This book advances the understanding of: how the brain carries out important tasks via networks; how these networks interact in normal brain function; major mechanisms that control network function; and the interaction of the normal networks to produce more complex behaviors.
Автор: Stone Название: CNS Neurotransmitters and Neuromodulators ISBN: 0849376300 ISBN-13(EAN): 9780849376306 Издательство: Taylor&Francis Рейтинг: Цена: 53592.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The series CNS Neurotransmitters and Neuromodulators is destined to be the definitive reference work on the physiology and pharmacology of the central nervous system
Автор: Tonn Название: Oncology of CNS tumors ISBN: 364202873X ISBN-13(EAN): 9783642028731 Издательство: Springer Рейтинг: Цена: 32004.00 р. Наличие на складе: Поставка под заказ.
Описание: Since the first edition of this popular reference, many new diagnostic procedures and treatment modalities have been developed within neuro-oncology. This edition contains those advances and includes new chapters on palliative care and molecular markers.
Название: White Matter Injury in Stroke and CNS Disease ISBN: 1461491223 ISBN-13(EAN): 9781461491224 Издательство: Springer Рейтинг: Цена: 30039.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book provides systematic expert summaries of normal white matter morphology and details white matter injury following stroke and other CNS injuries. It features key notes and implementation advice from the experts.
Автор: H.D. Perez; B. Mitrovic; A. Baron Van Evercooren Название: Opportunities and Challenges of the Therapies Targeting CNS Regeneration ISBN: 3642421482 ISBN-13(EAN): 9783642421488 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: New Strategies for CNS Repair.- Heterogeneity of Multiple Sclerosis: Implications for Therapy Targeting Regeneration.- The Neuroprotective Effect of Inflammation: Implications for the Therapy of Multiple Sclerosis.- Fibroblast Growth Factors in Oligodendrocyte Physiology and Myelin Repair.- White Matter Progenitor Cells Reside in an Oligodendrogenic Niche.- At the Interface of the Immune System and the Nervous System: How Neuroinflammation Modulates the Fate of Neural Progenitors In Vivo.- Remyelination and Restoration of Axonal Function by Glial Cell Transplantation.- Gene and Stem Cell Therapy for Autoimmune Demyelination.- Novel Gene Therapeutic Strategies for Neurodegenerative Diseases.- Measuring Injury and Repair of Myelin and Neurons in Multiple Sclerosis.
Автор: David Borsook; Lino R. Beccera; Edward Bullmore; R Название: Imaging in CNS Drug Discovery and Development ISBN: 1489984747 ISBN-13(EAN): 9781489984746 Издательство: Springer Рейтинг: Цена: 26120.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Distilling the most salient developments in the use of imaging in drug development and disease mapping, this text integrates new imaging technologies and paradigms with molecular medicine and molecular profiling, and considers the relevant ethical issues.
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